AC T04546
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ID T04546
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DT 06.06.2001 (created); bme.
DT 13.01.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA NeuroD
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SY Beta2; Neurogenic differentiation factor 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002545 NEUROD1; HGNC: NEUROD1.
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CL C0010; bHLH; 1.2.3.4.1.
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SF N- and C-terminal domains of BETA2 are necessary for efficient transcription by the insulin promoter [5];
SF efficient DNA-binding requires dimerization with bhlh protein;
SF heterodimer with E47 [3];
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CP brain; intestine, pancreatic cells [2].
EX pancreas,,,adult; detectable.
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FF transcriptional activator;
FF binds to the insulin gene E-Box;
FF acts as differentiation factor during neurogenesis;
FF plays pivotal role in tissue-specific differentiation [2];
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IN T06148 p/CAF; human, Homo sapiens.
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MX M01287 V$NEUROD_01.
MX M01288 V$NEUROD_02.
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BS R34978.
BS R31175.
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DR TRANSPATH: MO000028384.
DR PATHODB: MT010865.
DR PATHODB: MT010866.
DR PATHODB: MT010869.
DR UniProtKB: Q13562;
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RN [1]; RE0016256.
RX PUBMED: 10545951.
RA Malecki M. T., Jhala U. S., Antonellis A., Fields L., Doria A., Orban T., Saad M., Warram J. H., Montminy M., Krolewski A. S.
RT Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus.
RL Nat. Genet. 23:323-328 (1999).
RN [2]; RE0016285.
RX PUBMED: 9714454.
RA Yoon Y. S., Noma T., Yamashiro Y., Ito H., Nakazawa A.
RT Molecular cloning and characterization of the gene encoding human NeuroD.
RL Neurosci. Lett. 251:17-20 (1998).
RN [3]; RE0016351.
RX PUBMED: 10366743.
RA Miyachi T., Maruyama H., Kitamura T., Nakamura S., Kawakami H.
RT Structure and regulation of the human NeuroD (BETA2/BHF1) gene.
RL Brain Res. Mol. Brain Res. 69:223-231 (1999).
RN [4]; RE0035553.
RX PUBMED: 14701848.
RA Qiu Y., Guo M., Huang S., Stein R.
RT Acetylation of the BETA2 transcription factor by p300-associated factor is important in insulin gene expression.
RL J. Biol. Chem. 279:9796-9802 (2004).
RN [5]; RE0048141.
RX PUBMED: 10636926.
RA Glick E., Leshkowitz D., Walker M. D.
RT Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter.
RL J. Biol. Chem. 275:2199-2204 (2000).
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