AC T04619
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ID T04619
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DT 19.07.2001 (created); mas.
DT 15.04.2009 (updated); sva.
CO Copyright (C), QIAGEN.
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FA PXR-isoform2
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SY NR1I2; pregnane X receptor; PXR.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002752 Nr1i2.
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CL C0002; CC (rec).
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SZ 390 AA; 45.0 kDa (cDNA) (calc.).
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SQ MRPEESWSRVGLVQCEEADSALEEPINVEEEDGGLQICRVCGDKANGYHFNVMTCEGCKG
SQ FFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRA
SQ LIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQTFDTTFSHFKDFRLRGEDGSIWN
SQ YQPPSKSDGKEIIPLLPHLADVSTYMFKGVINFAKVISYFRDLPIEDQISLLKGATFEMC
SQ ILRFNTMFDTETGTWECGRLAYCFEDPNGGFQKLLLDPLMKFHCMLKKLQLHKEEYVLMQ
SQ AISLFSPDRPGVVQRSVVDQLQERFALTLKAYIECSRPYPAHRFLFLKIMAVLTELRSIN
SQ AQQTQQLLRIQDSHPFATPLMQELFSSTDG
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SC translated from [1] (Kliewer et al. 1988, Cell 92, pp. 73-82)
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FT 1 242 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 35 107 
SM00399; c4gold.
FT 35 111 
PS51030; NUCLEAR_REC_DBD_2.
FT 36 112 
PF00105; Zinc finger, C4 type (two domains).
FT 38 104 
DNA-binding domain [1].
FT 138 390 
putative ligand-binding domain [1].
FT 201 360 
SM00430; holi.
FT 204 384 
PF00104; Ligand-binding domain of nuclear hormon.
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EX adrenal gland (right + left),,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX brain,,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX brain,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX epithelial layer of gastrointestinal tract,,,Theiler Stage 26; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX heart,,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX heart,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX intestine,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX kidney (right and left),,,adult; low; Northern blot; mRNA (poly-A); [1].
EX liver,,,Theiler Stage 26; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX liver,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX lung,,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX lung,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX muscles,,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX muscles,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX skin,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX spinal cord,,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX spleen,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX stomach,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX testis (right and left),,,adult; none; Northern blot; mRNA (poly-A); [1].
EX thymus,,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX thymus,,,adult; none; Northern blot; mRNA (poly-A); [1].
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FF smaller range of activating ligands than isoform T04618 probably due to shorter ligand-binding domain [1];
FF activating ligands: dexamethasone-t-butyl-acetate (artificial ligand), 5beta-3,20-dione (naturally occurring) [1];
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IN T01345 RXR-alpha; human, Homo sapiens.
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MX M00966 V$DR3_Q4.
MX M00965 V$DR4_Q2.
MX M07280 V$NR1NR2_Q3.
MX M00964 V$PXR_Q2.
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DR TRANSPATH: MO000028452.
DR EMBL: AF031814;
DR UniProtKB: O54915-2;
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RN [1]; RE0016460.
RX PUBMED: 9489701.
RA Kliewer S. A., Moore J. T., Wade L., Staudinger J. L., Watson M. A., Jones S. A., McKee D. D., Oliver B. B., Willson T. M., Zetterstrom R. H., Perlmann T., Lehmann J. M.
RT An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
RL Cell 92:73-82 (1998).
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//