AC T04701
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ID T04701
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DT 04.09.2001 (created); rio.
DT 01.09.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA AP-2rep
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SY AP-2 repressor; KLF12.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002619 Klf12.
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CL C0001; CH; 2.3.1.2.12.
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SF the PVDLS motif is both necessary and sufficient for transcriptional repression [2];
SF zinc fingers are concluded to function as sequence-specific DNA-binding domain without significant intrinsic transcriptional regulatory activity [2];
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EX adrenal gland (right + left),,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX amygdaloid body,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX aorta,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX appendix,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX blood,basophil granulocyte,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX blood,eosinophil granulocyte,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX blood,lymphocyte,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX blood,monocyte,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX blood,neutrophil granulocyte,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX bone marrow,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX brain,,,Theiler Stage 24; high; RT-PCR; total RNA; [1].
EX brain,,,Theiler Stage 27; low; RT-PCR; total RNA; [1].
EX brain,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX brain,,,fetal; none; gel shift (RNA); mRNA (poly-A); [1].
EX brain,,,neonate (during the first month after birth); very high; RT-PCR; total RNA; [1].
EX caudate nucleus,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX cerebellum,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX cerebral cortex,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX colon,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX frontal lobe of medial and inferior surfaces,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX frontal lobe of superolateral face,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX heart,,,Theiler Stage 24; low; RT-PCR; total RNA; [1].
EX heart,,,Theiler Stage 27; low; RT-PCR; total RNA; [1].
EX heart,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX heart,,,fetal; none; gel shift (RNA); mRNA (poly-A); [1].
EX heart,,,neonate (during the first month after birth); low; RT-PCR; total RNA; [1].
EX hippocampus,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX kidney (right and left),,,Theiler Stage 24; low; RT-PCR; total RNA; [1].
EX kidney (right and left),,,Theiler Stage 27; medium; RT-PCR; total RNA; [1].
EX kidney (right and left),,,adult; high; gel shift (RNA); mRNA (poly-A); [1].
EX kidney (right and left),,,fetal; none; gel shift (RNA); mRNA (poly-A); [1].
EX kidney (right and left),,,neonate (during the first month after birth); high; RT-PCR; total RNA; [1].
EX liver,,,adult; very low; gel shift (RNA); mRNA (poly-A); [1].
EX liver,,,fetal; none; gel shift (RNA); mRNA (poly-A); [1].
EX lung,,,adult; very low; gel shift (RNA); mRNA (poly-A); [1].
EX lung,,,fetal; none; gel shift (RNA); mRNA (poly-A); [1].
EX lymph node,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX mammary gland,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX muscles,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX myelencephalon,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX occipital lobe of medial and inferior surfaces,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX occipital lobe of superolateral face,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX ovary,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX pancreas,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX pituitary gland of diencephalon,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX placenta,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX prostate gland,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX putamen,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX salivary gland,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX small intestine,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX spinal cord,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX spleen,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX spleen,,,fetal; none; gel shift (RNA); mRNA (poly-A); [1].
EX stomach,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX substantia nigra,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX subthalamic nucleus,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX temporal lobe of medial and inferior surfaces,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX temporal lobe of superolateral face,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX testis (right and left),,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX thalamus,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX thymus,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX thymus,,,fetal; none; gel shift (RNA); mRNA (poly-A); [1].
EX thyroid gland,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX trachea,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX urinary bladder,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
EX uterus,,,adult; none; gel shift (RNA); mRNA (poly-A); [1].
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FF strong transcriptional repressor of AP-2alpha T00033 promoter activity [1];
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IN T08110 CtBP1; mouse, Mus musculus.
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MX M00468 V$AP2REP_01.
MX M03915 V$KLF12_02.
MX M07461 V$KLF_Q3.
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DR TRANSPATH: MO000028514.
DR UniProtKB: O35738;
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RN [1]; RE0016804.
RX PUBMED: 9858544.
RA Imhof A., Schuierer M., Werner O., Moser M., Roth C., Bauer R., Buettner R.
RT Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor
RL Mol. Cell. Biol. 19:194-204 (1999).
RN [2]; RE0035237.
RX PUBMED: 11373277.
RA Schuierer M., Hilger-Eversheim K., Dobner T., Bosserhoff A.-K., Moser M., Turner J., Crossley M., Buettner R.
RT Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1.
RL J. Biol. Chem. 276:27944-27949 (2001).
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