AC T04734
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ID T04734
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DT 07.09.2001 (created); rio.
DT 16.08.2011 (updated); yre.
CO Copyright (C), QIAGEN.
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FA LUN-isoform1
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SY LUN; lung; topoisomerase I binding, arginine/serine-rich; TOPORS; TP53BPL.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002662 TOPORS; HGNC: TOPORS.
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CL C0049; RING.
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SZ 1045 AA; 119.2 kDa (calc.).
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SQ MGSQPPLGSPLSREEGEAPPPAPASEGRRRSRRVRLRGSCRHRPSFLGCRELAASAPARP
SQ APASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCL
SQ HKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFVTPDRRFRY
SQ RTTLTRERNASVYSPSGPVNRRTTTPPDSGVLFEGLGISTRPRDVEIPQFMRQIAVRRPT
SQ TADERSLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWL
SQ KRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFAR
SQ SPFNMAAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDINVATVSQAPWDDET
SQ PGPSYSSSEQVHVTMSSLLNTSDSSDEELVTGGATSQIQGVQTNDDLNNDSDDSSDNCVI
SQ VGFVKPLAERTPELVELSSDSEDLGSYEKMETVKTQEQEQSYSSGDSDVSRCSSPHSVLG
SQ KDEQINKGHCDSSTRIKSKKEEKRSTSLSSPRNLNSSVRGDRVYSPYNHRHRKRGRSRSS
SQ DSRSQSRSGHDQKNHRKHHGKKRMKSKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTL
SQ SLSSESTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSY
SQ RRRTLSRAHYSRQSSSPEFRVQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSRTA
SQ STGTDRVRNEKPGGKRKYKTRHLEGTNEVAQPSREFASKAKDSHYQKSSSKLDGNYKNES
SQ DTFSDSRSSDRETKHKRRKRKTRSLSVEIVYEGKATDTTKHHKKKKKKHKKKHKKHHGDN
SQ ASRSPVVITIDSDSDKDSEVKEDTECDNSGPQDPLQNEFLAPSLEPFETKDVVTIEAEFG
SQ VLDKECDIATLSNNLNNANKTVDNIPPLAASVEQTLDVREESTFVSDLENQPSNIVSLQT
SQ EPSRQLPSPRTSLMSVCLGRDCDMS
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SC translated from EMBL #AB045732
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FT 13 28 
PEST sequence [1].
FT 103 141 
RING finger domain [1].
FT 103 141 
PF00097; Zinc finger, C3HC4 type (RING finger).
FT 103 141 
SM00184; ring_2.
FT 103 142 
PS50089; ZF_RING_2.
FT 293 365 
putative leucine zipper [1].
FT 386 432 
PEST sequence [1].
FT 490 509 
PEST sequence [1].
FT 616 622 
putative NLS (nuclear localization signal) [1].
FT 616 645 
putative bipartite nuclear localization signal [1].
FT 700 703 putative SUMO-1 conjugation site [1].
FT 836 839 putative SUMO-1 conjugation site [1].
FT 921 950 PEST sequence [1].
FT 999 1024 PEST sequence [1].
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SF Zn2+ ions with either Mg2+, Mn2+ or Ca2+ are essential for the binding of LUN to DNA [1];
SF binds to a palindromic binding consensus (TCCCAgcacttTGGGA) [1];
SF splice variant LUN-2 T04736;
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CP (cell lines:) T98, Molt-4, (adult:) most highly expressed in lung (alveolar epithelium), moderate expression in heart, brain, skeletal muscle, kidney, liver, spleen, pancreas [1].
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FF might be an important transcriptional regulator for lung cancer-associated genes including E-cadherin and talin [1];
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IN T14127 SATB1-isoform1; human, Homo sapiens.
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MX M00480 V$LUN1_01.
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BS R10982.
BS R10983.
BS R10984.
BS R10985.
BS R10986.
BS R10987.
BS R10988.
BS R10989.
BS R10990.
BS R10991.
BS R10992.
BS R10993.
BS R10994.
BS R10995.
BS R10996.
BS R10997.
BS R10998.
BS R10999.
BS R11000.
BS R11001.
BS R11002.
BS R11003.
BS R11004.
BS R11005.
BS R11006.
BS R11007.
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DR TRANSPATH: MO000028546.
DR EMBL: AB045732;
DR UniProtKB: Q9NS56;
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RN [1]; RE0016839.
RX PUBMED: 11278651.
RA Chu D., Kakazu N., Gorrin-Rivas M. J., Lu H. P., Kawata M., Abe T., Ueda K., Adachi Y.
RT Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence
RL J. Biol. Chem. 276:14004-14013 (2001).
RN [2]; RE0049485.
RX PUBMED: 16122737.
RA Weger S., Hammer E., Heilbronn R.
RT Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo.
RL FEBS Lett. 579:5007-5012 (2005).
RN [3]; RE0049492.
RX PUBMED: 15247280.
RA Rajendra R., Malegaonkar D., Pungaliya P., Marshall H., Rasheed Z., Brownell J., Liu L. F., Lutzker S., Saleem A., Rubin E. H.
RT Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.
RL J. Biol. Chem. 279:36440-36444 (2004).
RN [4]; RE0070893.
RX PUBMED: 20351170.
RA Tan J. A., Song J., Chen Y., Durrin L. K.
RT Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.
RL Mol. Cell. Biol. 30:2823-2836 (2010).
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//