AC T04798
XX
ID T04798
XX
DT 20.09.2001 (created); mas.
CO Copyright (C), QIAGEN.
XX
FA Bach1t
XX
SY BTB and CNC homolog 1; transcription regulator protein BACH1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002726 BACH1; HGNC: BACH1.
XX
CL C0008; bZIP.
XX
SZ 623 AA; 69.8 kDa (calc.).
XX
SQ MSLSENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFH
SQ SRIVGQADGELNITLPEEVTVKGFEPLIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEE
SQ SCFQFLKFKFLDSTADQQECPRKKCFSSHCQKTDLKLSLLDQRDLETDEVEEFLENKNVQ
SQ TPQCKLRRYQGNAKASPPLQDSASQTYESMCLEKDAALALPSLCPKYRKFQKAFGTDRVR
SQ TGESSVKDIHASVQPNERSENECLGGVPECRDLQVMLKCDESKLAMEPEETKKDPASQCP
SQ TEKSEVTPFPHNSSIDPHGLYSLSLLHTYDQYGDLNFAGMQNTTVLTEKPLSGTDVQEKT
SQ FGESQDLPLKSDLGTREDSSVASSDRSSVEREVAEHLAKGFWSDICSTDTPCQMQLSPAV
SQ AKDGSEQISQKRSECPWLGIRISESPEPGQRTFTTLSSVNCPFISTLSTEGCSSNLEIGN
SQ DDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQECEVKLPFNAQRIISLSRND
SQ FQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLGSVENLMC
SQ QEVFHTILRTLDTCSDSSVSAKQ
XX
SC translated from EMBL #AF124731 and modified according to [1] (from pos. 593 onwards)
XX
FT 16 122 
BTB domain [2].
FT 24 130 
PF00651; BTB/POZ domain.
FT 34 100 
PS50097; BTB.
FT 34 130 
SM00225; BTB_4.
FT 553 619 
SM00338; brlzneu.
FT 558 609 
PF00170; bZIP transcription factor.
FT 562 578 
truncated remainder of leucine zipper [1].
FT 562 592 
PS50217; BZIP.
FT 579 592 
basic portion of bZIP [1].
XX
SF isoform of T04791 without complete bZIP domain (basic region still present but leucine zipper truncated) [1];
XX
EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; low; RT-PCR; RNA (undefined); [1].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; low; RT-PCR; RNA (undefined); [1].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; low; RT-PCR; RNA (undefined); [1].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; low; RT-PCR; RNA (undefined); [1].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; low; RT-PCR; RNA (undefined); [1].
EX colon,,,adult; medium; RT-PCR; RNA (undefined); [1].
EX ovary (right and left),,,adult; medium; RT-PCR; RNA (undefined); [1].
EX prostate gland,,,adult; medium; RT-PCR; RNA (undefined); [1].
EX small intestine,,,adult; low; RT-PCR; RNA (undefined); [1].
EX spleen,,,adult; medium; RT-PCR; RNA (undefined); [1].
EX testis (right and left),,,adult; very high; RT-PCR; RNA (undefined); [1].
EX thymus,,,adult; low; RT-PCR; RNA (undefined); [1].
XX
FF in contrast to longer isoform T04791 no binding to beta-globin gene binding site R01946 (both in the absence and in the presence of heterodimer partner MafK of longer isoform) [1];
FF seems to have no DNA-binding activity at all [1];
FF interacts with Bach1/MafK heterodimer through BTB domain [1];
FF can mediate nuclear import of its longer isoform T04791 [1];
XX
IN T04791 Bach1; human, Homo sapiens.
XX
MX M00495 V$BACH1_01.
MX M07374 V$BACH1_Q3.
MX M07296 V$MAF_Q4.
MX M00983 V$MAF_Q6_01.
XX
DR TRANSPATH: MO000028608.
DR EMBL: AF124731;
DR UniProtKB: O14867;
XX
RN [1]; RE0016918.
RX PUBMED: 11069897.
RA Kanezaki R., Toki T., Yokoyama M., Yomogida K., Sugiyama K., Yamamoto M., Igarashi K., Ito E.
RT Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform
RL J. Biol. Chem. 276:7278-7284 (2001).
RN [2]; RE0016919.
RX PUBMED: 9544839.
RA Blouin J. L., Duriaux Sail G., Guipponi M., Rossier C., Pappasavas M. P., Antonarakis S. E.
RT Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1
RL Hum. Genet. 102:282-288 (1998).
XX
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