AC T05053
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ID T05053
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DT 28.02.2002 (created); mas.
DT 02.09.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA BTEB4
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SY basic transcription element binding protein 4; bte-binding protein 4; BTEB-4; dopamine receptor regulating factor; DRRF.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G003041 Klf16.
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CL C0001; CH; 2.3.1.2.16.
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CP (adult:) highest levels in brain, also expressed in heart, spleen, lung, liver, kidney, testis [1]; in situ: highest levels in hippocampal CA1 region, cerebral cortex, dentate gyrus, amygdala, lower levels in hippocampal CA2-CA3 region, piriform cortex, septum, thalamic nuclei [1] [1].
EX amygdaloid body,,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX brain,,,adult; very high; Northern blot; mRNA (poly-A); [1].
EX cerebellum,,,adult; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX cerebral cortex,,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX corpus striatum,,,adult; very high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX dentate gyrus,,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX habenula,,,adult; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX heart,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX liver,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX lung,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX nucleus accumbens,,,adult; very high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX olfactory bulb,,,adult; very high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX olfactory tubercle,,,adult; very high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX paraventricular nucleus of thalamus,,,adult; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX piriform cortex,,,adult; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX region I of hippocampus proper,,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX region II of hippocampus proper,,,adult; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX region III of hippocampus proper,,,adult; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX septum pellucidum,,,adult; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX spleen,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX testis (right and left),,,adult; high; Northern blot; mRNA (poly-A); [1].
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FF repressor (e.g. on dopamine receptor D2 and D1A promoters, and BCAT-2 reporter plasmid) [1];
FF seems to inhibit activation induced by its superfamily member Sp1 T00752 (on BCAT-2 reporter plasmid) [1];
FF partial colocalization with dopamine receptors D2 and D1A in adult mouse brain (striatum) on RNA level [1];
FF significant alterations in expression levels (mRNA) in mice treated with drugs that either increase extracellular striatal dopamine levels (cocaine), block dopamine receptors (haloperidol), or destroy dopamine terminals (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) [1];
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MX M05329 V$BTEB4_01.
MX M07461 V$KLF_Q3.
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DR TRANSPATH: MO000028796.
DR UniProtKB: P58334;
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RN [1]; RE0017589.
RX PUBMED: 11390978.
RA Hwang C. K., DSouza U. M., Eisch A. J., Yajima S., Lammers C. H., Yang Y., Lee S. H., Kim Y. M., Nestler E. J., Mouradian M. M.
RT Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor
RL Proc. Natl. Acad. Sci. USA 98:7558-7563 (2001).
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//