AC T05257
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ID T05257
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DT 04.10.2002 (created); oke.
DT 06.12.2005 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA CAR2:RXR-alpha
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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CL C0002; CC (rec).
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SF heterodimer, for individual polypeptides see mouse CAR T05687 and mouse RXR-alpha T01331;
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FF activator [1] [3] [4] [5];
FF recognizes retinoic acid response elements (RAREs) of DR5 type [1] [4];
FF recognizes DR4 elements [3] [4] [5];
FF recognizes DR3 elements [4] [5];
FF recognizes ER6 elements [4];
FF activates gene encoding enzyme of the peroxisomal beta-oxidation pathway, hydratase/dehydrogenase (HD), in the absence of the ligand [2];
FF plays a role in fatty acid homeostasis [2];
FF activates cyp2b gene in response to phenobarbital [3];
FF activates cyp2b and cyp3a genes in response to TCPOBOP [4];
FF binds to the same DNA elements as PXRR:RXR heterodimer, but provides induction by distinct xenobiotics [5];
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MX M03788 V$CARRXR_Q2.
MX M00966 V$DR3_Q4.
MX M00965 V$DR4_Q2.
MX M07280 V$NR1NR2_Q3.
MX M00964 V$PXR_Q2.
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BS R10090.
BS R01321.
BS R14201.
BS R14202.
BS R09957.
BS R14178.
BS R14219.
BS R14220.
BS R10080.
BS R13013.
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DR TRANSPATH: MO000033865.
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RN [1]; RE0013646.
RX PUBMED: 9295294.
RA Choi H. S., Chung M., Tzameli I., Simha D., Lee Y. K., Seol W., Moore D. D.
RT Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR
RL J. Biol. Chem. 272:23565-23571 (1997).
RN [2]; RE0018044.
RX PUBMED: 10660604.
RA Kassam A., Winrow C. J., Fernandez-Rachubinski F., Capone J. P., Rachubinski R. A.
RT The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated transactivation.
RL J. Biol. Chem. 275:4345-4350 (2000).
RN [3]; RE0023321.
RX PUBMED: 9742082.
RA Honkakoski P., Zelko I., Sueyoshi T., Negishi M.
RT The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene.
RL Mol. Cell. Biol. 18:5652-5658 (1998).
RN [4]; RE0023337.
RX PUBMED: 10757780.
RA Tzameli I., Pissios P., Schuetz E. G., Moore D. D.
RT The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR.
RL Mol. Cell. Biol. 20:2951-2958 (2000).
RN [5]; RE0023346.
RX PUBMED: 11278292.
RA Smirlis D., Muangmoonchai R., Edwards M., Phillips I. R., Shephard E. A.
RT Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics.
RL J. Biol. Chem. 276:12822-12826 (2001).
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