TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T05673 XX ID T05673 XX DT 08.09.2003 (created); oke. DT 15.04.2009 (updated); sva. CO Copyright (C), QIAGEN. XX FA PXR-isoform1:RXR-alpha XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0002; CC (rec). XX SF heterodimer, for individual polypeptides see mouse PXR-isoform1 T04618 and mouse RXR-alpha T01331; XX FF activator; FF activates transcription in response to steroids and xenobiotics; FF regulator of liver-specific expression of genes encoding enzymes of xenobiotic metabolism [1] [2] [3] [4]; FF has been shown to bind different DNA elements; FF may bind to DR3 [1] [4]; FF may bind to DR4 [2] [4]; FF may bind to ER6 [3]; FF mediates induction of cyp2b and cyp3a genes by PCN (synthetic pregnenolone) [4]; FF binds to the same DNA elements as CAR:RXR heterodimer, but provides induction by distinct xenobiotics [4]; XX MX M00966 V$DR3_Q4. MX M00965 V$DR4_Q2. MX M07280 V$NR1NR2_Q3. MX M03810 V$RXRPXR_Q2. XX BS R14175. BS R10090. BS R14178. BS R14220. BS R10080. BS R12029. BS R10081. XX DR TRANSPATH: MO000054364. XX RN [1]; RE0016460. RX PUBMED: 9489701. RA Kliewer S. A., Moore J. T., Wade L., Staudinger J. L., Watson M. A., Jones S. A., McKee D. D., Oliver B. B., Willson T. M., Zetterstrom R. H., Perlmann T., Lehmann J. M. RT An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway RL Cell 92:73-82 (1998). RN [2]; RE0017441. RX PUBMED: 10860926. RA Huss J. M., Kasper C. B. RT Two-stage glucocorticoid induction of CYP3A23 through both the glucocorticoid and pregnane X receptors. RL Mol. Pharmacol. 58:48-57 (2000). RN [3]; RE0023228. RX PUBMED: 9727070. RA Lehmann J. M., McKee D. D., Watson M. A., Willson T. M., Moore J. T., Kliewer S. A. RT The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. RL J. Clin. Invest. 102:1016-1023 (1998). RN [4]; RE0023346. RX PUBMED: 11278292. RA Smirlis D., Muangmoonchai R., Edwards M., Phillips I. R., Shephard E. A. RT Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics. RL J. Biol. Chem. 276:12822-12826 (2001). XX //