AC T05838
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ID T05838
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DT 04.02.2004 (created); elf.
DT 20.04.2016 (updated); nes.
CO Copyright (C), QIAGEN.
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FA DEC1
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SY basic helix-loop-helix domain containing, class B, 2; basic helix-loop-helix family, member e40; BHLHB2; BHLHE40; DEC1; Differentially expressed in chondrocytes protein 1; Enhancer-of-split and hairy-related protein 2; FLJ99214; HLHB2; SHARP-2; Stimulated with retinoic acid 13; Stra13; Stra14.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009148 BHLHE40; HGNC: BHLHE40.
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CL C0010; bHLH; 1.2.4.1.12.
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CP cartilage, lung, spleen, intestine [1].
CN brain [1].
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FF repressor [2];
FF expressed in the chondrocytes in response to Bt2cAMP [1];
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IN T18011 ESET; human, Homo sapiens.
IN T18835 Mi2-alpha; human, Homo sapiens.
IN T11165 NKX3A; human, Homo sapiens.
IN T14648 PRDII-BF1; human, Homo sapiens.
IN T04355 zhx1; human, Homo sapiens.
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MX M04720 V$BHLHE40_03.
MX M03572 V$DEC1_Q2.
MX M08870 V$DEC1_Q3.
MX M00997 V$DEC_Q1.
MX M08872 V$DEC_Q3.
MX M01034 V$EBOX_Q6_01.
MX M08885 V$HAIRYLIKE_Q3.
MX M00985 V$STRA13_01.
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BS R40824.
BS R68774.
BS R68800.
BS R72871.
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DR TRANSPATH: MO000039154.
DR UniProtKB: O14503;
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RN [1]; RE0023787.
RX PUBMED: 9240428.
RA Shen M., Kawamoto T., Yan W., Nakamasu K., Tamagami M., Koyano Y., Noshiro M., Kato Y.
RT Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes.
RL Biochem. Biophys. Res. Commun. 236:294-298 (1997).
RN [2]; RE0023789.
RX PUBMED: 12624110.
RA Li Y., Xie M., Song X., Gragen S., Sachdeva K., Wan Y., Yan B.
RT DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter.
RL J. Biol. Chem. 278:16899-16907 (2003).
RN [3]; RE0023861.
RX PUBMED: 11880636.
RA Zawel L., Yu J., Torrance C. J., Markowitz S., Kinzler K. W., Vogelstein B., Zhou S.
RT DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities.
RL Proc. Natl. Acad. Sci. USA 99:2848-2853 (2002).
RN [4]; RE0063261.
RX PUBMED: 16169070.
RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E.
RT A human protein-protein interaction network: a resource for annotating the proteome.
RL Cell 122:957-968 (2005).
RN [5]; RE0066549.
RX PUBMED: 18345027.
RA Nakamura H., Tanimoto K., Hiyama K., Yunokawa M., Kawamoto T., Kato Y., Yoshiga K., Poellinger L., Hiyama E., Nishiyama M.
RT Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2.
RL Oncogene 27:4200-4209 (2008).
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