AC T05946
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ID T05946
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DT 04.05.2004 (created); oke.
DT 26.10.2009 (updated); bjo.
CO Copyright (C), QIAGEN.
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FA MeCP-2
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SY ARBP/MeCP2; MECP2; methyl-CpG-binding protein 2.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009421 Mecp2.
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HO chicken ARBP [3].
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SF phosphorylated form shows little binding to the methylated CpG [4];
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CP highly expressed in central nervous system; high levels in brain, low levels in testes [1].
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FF repressor;
FF originally identified through its ability to recognize methylated DNA [1];
FF transcriptional repressor [1];
FF in the absence of neuronal activity binds to and represses BDNF promoter III [4];
FF becomes phosphorylated in response to calcium influx in 15 to 30 minutes after membrane depolarization [4];
FF may provide a mechanistic bridge between DNA methylation and histone deacetylation [5];
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IN T23418 HDAC1; mouse, Mus musculus.
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MX M01298 V$MECP2_01.
MX M01299 V$MECP2_02.
MX M07049 V$MECP2_Q4.
MX M07388 V$MECP2_Q4_01.
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BS R14836.
BS R72947.
BS R71406.
BS R71407.
BS R71408.
BS R71409.
BS R71410.
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DR TRANSPATH: MO000041662.
DR SMARTDB: SB000103.
DR UniProtKB: Q00566; MEC2_RAT.
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RN [1]; RE0007574.
RX PUBMED: 1408825.
RA Meehan R. R., Lawis J. D., Bird A. P.
RT Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA
RL Nucleic Acids Res. 20:5085-5092 (1992).
RN [2]; RE0008652.
RX PUBMED: 8177735.
RA Nan X., Meehan R. R., Bird A.
RT Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2
RL Nucleic Acids Res. 21:4886-4892 (1993).
RN [3]; RE0015861.
RX PUBMED: 9271441.
RA Weitzel J. M., Buhrmester H., Straetling W. H.
RT Chicken MAR-binding protein ARBP is homologous to rat methyl-CpG-binding protein MeCP2
RL Mol. Cell. Biol. 17:5656-5666 (1997).
RN [4]; RE0024177.
RX PUBMED: 14593183.
RA Chen W. G., Chang Q., Lin Y., Meissner A., West A. E., Griffith E. C., Jaenisch R., Greenberg M. E.
RT Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2.
RL Science 302:885-889 (2003).
RN [5]; RE0024625.
RX PUBMED: 9620804.
RA Nan X., Ng H.-H., Johnson C. A., Laherty C. D., Turner B. M., Eisenman R. N., Bird A.
RT Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
RL Nature 393:386-389 (1998).
RN [6]; RE0047443.
RX PUBMED: 12473678.
RA Kimura H., Shiota K.
RT Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1.
RL J. Biol. Chem. 278:4806-4812 (2003).
RN [7]; RE0048041.
RX PUBMED: 15322089.
RA Klose R. J., Bird A. P.
RT MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex.
RL J. Biol. Chem. 279:46490-46496 (2004).
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