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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T05946 XX ID T05946 XX DT 04.05.2004 (created); oke. DT 26.10.2009 (updated); bjo. CO Copyright (C), QIAGEN. XX FA MeCP-2 XX SY ARBP/MeCP2; MECP2; methyl-CpG-binding protein 2. XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G009421 Mecp2. XX HO chicken ARBP [3]. XX SF phosphorylated form shows little binding to the methylated CpG [4]; XX CP highly expressed in central nervous system; high levels in brain, low levels in testes [1]. XX FF repressor; FF originally identified through its ability to recognize methylated DNA [1]; FF transcriptional repressor [1]; FF in the absence of neuronal activity binds to and represses BDNF promoter III [4]; FF becomes phosphorylated in response to calcium influx in 15 to 30 minutes after membrane depolarization [4]; FF may provide a mechanistic bridge between DNA methylation and histone deacetylation [5]; XX IN T23418 HDAC1; mouse, Mus musculus. XX MX M01298 V$MECP2_01. MX M01299 V$MECP2_02. MX M07049 V$MECP2_Q4. MX M07388 V$MECP2_Q4_01. XX BS R14836. BS R72947. BS R71406. BS R71407. BS R71408. BS R71409. BS R71410. XX DR TRANSPATH: MO000041662. DR SMARTDB: SB000103. DR UniProtKB: Q00566; MEC2_RAT. XX RN [1]; RE0007574. RX PUBMED: 1408825. RA Meehan R. R., Lawis J. D., Bird A. P. RT Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA RL Nucleic Acids Res. 20:5085-5092 (1992). RN [2]; RE0008652. RX PUBMED: 8177735. RA Nan X., Meehan R. R., Bird A. RT Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2 RL Nucleic Acids Res. 21:4886-4892 (1993). RN [3]; RE0015861. RX PUBMED: 9271441. RA Weitzel J. M., Buhrmester H., Straetling W. H. RT Chicken MAR-binding protein ARBP is homologous to rat methyl-CpG-binding protein MeCP2 RL Mol. Cell. Biol. 17:5656-5666 (1997). RN [4]; RE0024177. RX PUBMED: 14593183. RA Chen W. G., Chang Q., Lin Y., Meissner A., West A. E., Griffith E. C., Jaenisch R., Greenberg M. E. RT Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. RL Science 302:885-889 (2003). RN [5]; RE0024625. RX PUBMED: 9620804. RA Nan X., Ng H.-H., Johnson C. A., Laherty C. D., Turner B. M., Eisenman R. N., Bird A. RT Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex RL Nature 393:386-389 (1998). RN [6]; RE0047443. RX PUBMED: 12473678. RA Kimura H., Shiota K. RT Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. RL J. Biol. Chem. 278:4806-4812 (2003). RN [7]; RE0048041. RX PUBMED: 15322089. RA Klose R. J., Bird A. P. RT MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex. RL J. Biol. Chem. 279:46490-46496 (2004). XX //