AC T06000
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ID T06000
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DT 06.06.2004 (created); vma.
DT 24.07.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA Pbx1
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SY Homeobox protein PBX1; Homeobox protein PRL; Pbx1; pre-B-cell leukemia transcription factor 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002135 PBX1; HGNC: Pbx1.
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CL C0006; homeo; 3.1.4.4.1.
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SF two different splice variants, Pbx1a T01481 and Pbx1b T02087 [2];
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CP HepG2, HeLa, K562 and HEL [3].
CN B- and T- cell lineages [1].
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IN T02471 foxc1; human, Homo sapiens.
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MX M00096 V$PBX1_01.
MX M00124 V$PBX1_02.
MX M01017 V$PBX1_03.
MX M01357 V$PBX1_04.
MX M01967 V$PBX1_05.
MX M07451 V$PBX1_10.
MX M02028 V$PBX1_Q3.
MX M00998 V$PBX_Q3.
MX M07304 V$PBX_Q5.
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BS R15380.
BS R15382.
BS R15383.
BS R15384.
BS R15385.
BS R15388.
BS R15389.
BS R15390.
BS R15391.
BS R15392.
BS R15393.
BS R15394.
BS R15395.
BS R15396.
BS R15397.
BS R15398.
BS R15399.
BS R15400.
BS R15401.
BS R15402.
BS R15403.
BS R15404.
BS R15405.
BS R15406.
BS R15407.
BS R15408.
BS R15409.
BS R15410.
BS R15411.
BS R15412.
BS R15413.
BS R58455.
BS R58463.
BS R58476.
BS R58477.
BS R58497.
BS R25317.
BS R33038.
BS R33040.
BS R40137.
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DR TRANSPATH: MO000042273.
DR UniProtKB: P40424;
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RN [1]; RE0005178.
RX PUBMED: 7791786.
RA Lu Q., Knoepfler P. S., Scheele J., Wright D. D., Kamps M. P.
RT Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.
RL Mol. Cell. Biol. 15:3786-3795 (1995).
RN [2]; RE0024570.
RX PUBMED: 8183558.
RA LeBrun D. P., Cleary M. L.
RT Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias.
RL Oncogene 9:1641-1647 (1994).
RN [3]; RE0030968.
RX PUBMED: 12609849.
RA Okada Y., Nagai R., Sato T., Matsuura E., Minami T., Morita I., Doi T.
RT Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene.
RL Blood 101:4748-56 (2003).
RN [4]; RE0047186.
RX PUBMED: 15684392.
RA Berry F. B., O'Neill M. A., Coca-Prados M., Walter M. A.
RT FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner
RL Mol. Cell. Biol. 25:1415-24 (2005).
RN [5]; RE0047810.
RX PUBMED: 14701856.
RA Debril M. B., Gelman L., Fayard E., Annicotte J. S., Rocchi S., Auwerx J.
RT Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.
RL J. Biol. Chem. 279:16677-16686 (2004).
RN [6]; RE0048257.
RX PUBMED: 16574312.
RA Liu T., Branch D. R., Jin T.
RT Pbx1 is a co-factor for Cdx-2 in regulating proglucagon gene expression in pancreatic A cells.
RL Mol. Cell. Endocrinol. 249:140-149 (2006).
RN [7]; RE0065030.
RX PUBMED: 14512427.
RA Lu Y., Goldenberg I., Bei L., Andrejic J., Eklund E. A.
RT HoxA10 represses gene transcription in undifferentiated myeloid cells by interaction with histone deacetylase 2.
RL J. Biol. Chem. 278:47792-47802 (2003).
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