AC T06008
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ID T06008
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DT 09.06.2004 (created); cch.
DT 30.07.2014 (updated); sla.
CO Copyright (C), QIAGEN.
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FA p73alpha
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SY TAp73alpha; tumor protein p73 isoform a.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009621 Trp73.
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CL C0057; P53; 6.3.1.0.3.1.
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SZ 631 AA; 69.1 kDa (calc.).
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SQ MAQTSSSSSSTFEHLWSSLEPDSTYFDLPQPSQGTSEASGSEESNMDVFHLQGMAQFNLL
SQ SSAMDQMGSRAAPASPYTPEHAASAPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFE
SQ VTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVT
SQ DIVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLAQYVDDPVTGRQSVVVPYEPPQVGTE
SQ FTTILYNFMCNSSCVGGMNRRPILVIITLETRDGQVLGRRSFEGRICACPGRDRKADEDH
SQ YREQQALNESTTKNGAASKRAFKQSPPAIPALGTNVKKRRHGDEDMFYMHVRGRENFEIL
SQ MKVKESLELMELVPQPLVDSYRQQQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGVNKLPS
SQ VNQLVGQPPPHSSAAGPNLGPMGSGMLNSHGHSMPANGEMNGGHSSQTMVSGSHCTPPPP
SQ YHADPSLVSFLTGLGCPNCIECFTSQGLQSIYHLQNLTIEDLGALKVPDQYRMTIWRGLQ
SQ DLKQSHDCGQQLLRSSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGAGAVTG
SQ PDEWADFGFDLPDCKSRKQPIKEEFTETESH
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SC translated from EMBL #Y19234
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FT 21 576 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 105 301 
PF00870; P53 DNA-binding domain.
FT 337 378 
PF07710; P53 tetramerisation motif.
FT 479 545 
PF07647; SAM domain (Sterile alpha motif).
FT 479 545 
SM00454; SAM.
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SF there are several alternative variants known: p73alpha T06008, p73beta T06009, deltaNp73alpha T06288, deltaNp73beta T06289;
SF this isoform possesses transactivation, DNA binding, oligomerization and SAM domains;
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CP mRNA is highly expressed in a number of epithelial and neural structures [2].
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MX M00761 V$P53DECAMER_Q2.
MX M03558 V$P73_Q6.
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DR TRANSPATH: MO000042307.
DR EMBL: Y19234; MMY9234.
DR UniProtKB: Q9JJP2-1;
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RN [1]; RE0024344.
RX PUBMED: 11278685.
RA Strano S., Munarriz E., Rossi M., Castagnoli L., Shaul Y., Sacchi A., Oren M., Sudol M., Cesareni G., Blandino G.
RT Physical interaction with Yes-associated protein enhances p73 transcriptional activity.
RL J. Biol. Chem. 276:15164-15173 (2001).
RN [2]; RE0024977.
RX PUBMED: 10716451.
RA Yang A., Walker N., Bronson R., Kaghad M., Oosterwegel M., Bonnin J., Vagner C., Bonnet H., Dikkes P., Sharpe A., McKeon F., Caput D.
RT p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours.
RL Nature 404:99-103 (2000).
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