AC T06288
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ID T06288
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DT 13.10.2004 (created); oke.
DT 30.07.2014 (updated); sla.
CO Copyright (C), QIAGEN.
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FA DeltaNp73alpha
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SY DeltaNp73; tumor protein p73 isoform b.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009621 Trp73.
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CL C0057; P53; 6.3.1.0.3.7.
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SZ 590 AA; 64.7 kDa (calc.).
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SQ MLYVGDPMRHLATAQFNLLSSAMDQMGSRAAPASPYTPEHAASAPTHSPYAQPSSTFDTM
SQ SPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPP
SQ PPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLAQYVDDP
SQ VTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILVIITLETRDGQVLGRRS
SQ FEGRICACPGRDRKADEDHYREQQALNESTTKNGAASKRAFKQSPPAIPALGTNVKKRRH
SQ GDEDMFYMHVRGRENFEILMKVKESLELMELVPQPLVDSYRQQQQQQLLQRPSHLQPPSY
SQ GPVLSPMNKVHGGVNKLPSVNQLVGQPPPHSSAAGPNLGPMGSGMLNSHGHSMPANGEMN
SQ GGHSSQTMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIECFTSQGLQSIYHLQNLTIED
SQ LGALKVPDQYRMTIWRGLQDLKQSHDCGQQLLRSSSNAATISIGGSGELQRQRVMEAVHF
SQ RVRHTITIPNRGGAGAVTGPDEWADFGFDLPDCKSRKQPIKEEFTETESH
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SC translated from EMBL #Y19235
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FT 64 260 
PF00870; P53 DNA-binding domain.
FT 150 535 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 296 337 
PF07710; P53 tetramerisation motif.
FT 438 504 
PF07647; SAM domain (Sterile alpha motif).
FT 438 504 
SM00454; SAM.
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SF there are several alternative variants known: p73alpha T06008, p73beta T06009, deltaNp73alpha T06288, deltaNp73beta T06289;
SF this isoform, produced by the alternative promoter, lacks transactivation domain [2];
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CP developing neurons (predominant isoform) [1].
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FF regulated by Nerve Growth Factor [1];
FF protects neurons against apoptosis [1];
FF antagonizes the p53 function [1];
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IN T00671 p53; human, Homo sapiens.
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MX M00761 V$P53DECAMER_Q2.
MX M03558 V$P73_Q6.
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DR TRANSPATH: MO000044124.
DR EMBL: Y19235; MMU19235.
DR UniProtKB: Q9JJP2-2;
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RN [1]; RE0024736.
RX PUBMED: 10894779.
RA Pozniak C. D., Radinovic S., Yang A., McKeon F., Kaplan D. R., Miller F. D.
RT An anti-apoptotic role for the p53 family member, p73, during developmental neuron death.
RL Science 289:304-306 (2000).
RN [2]; RE0024977.
RX PUBMED: 10716451.
RA Yang A., Walker N., Bronson R., Kaghad M., Oosterwegel M., Bonnin J., Vagner C., Bonnet H., Dikkes P., Sharpe A., McKeon F., Caput D.
RT p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours.
RL Nature 404:99-103 (2000).
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