AC T06367
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ID T06367
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DT 01.12.2004 (created); cch.
DT 29.08.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA ASPP1
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SY apoptosis stimulating of p53 protein 1; KIAA0771; p53BP2-like; p85; Ppp1r13b; protein phosphatase 1, regulatory (inhibitor) subunit 13B.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G013615 PPP1R13B; HGNC: Ppp1r13b.
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FF ASPP1 stimulates transcriptional activity of p63gamma and p73alpha on promoters of Bax, PIG3, and PUMA but not of mdm2 and p21 [3];
FF ASPP1 stimulates DNA binding and transcriptional activity of p53 on proaptotic genes Bax and PIG-3 [1];
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IN T00671 p53; human, Homo sapiens.
IN T06135 p63-isoform5; human, Homo sapiens.
IN T04931 p73alpha; human, Homo sapiens.
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DR TRANSPATH: MO000044903.
DR UniProtKB: Q96KQ4;
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RN [1]; RE0016209.
RX PUBMED: 10462436.
RA Waxman D. J.
RT P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR
RL Arch. Biochem. Biophys. 369:11-23 (1999).
RN [2]; RE0024790.
RX PUBMED: 11684014.
RA Samuels-Lev Y., O Connor D. J., Bergamaschi D., Trigiante G., Hsieh J. K., Zhong S., Campargue I., Naumovski L., Crook T., Lu X.
RT ASPP proteins specifically stimulate the apoptotic function of p53.
RL Mol. Cell 8:781-794 (2001).
RN [3]; RE0025178.
RX PUBMED: 14729977.
RA Bergamaschi D., Samuels Y., Jin B., Duraisingham S., Crook T., Lu X.
RT ASPP1 and ASPP2: common activators of p53 family members.
RL Mol. Cell. Biol. 24:1341-1350 (2004).
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