AC T06429
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ID T06429
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DT 31.01.2005 (created); oke.
DT 30.07.2012 (updated); yre.
CO Copyright (C), QIAGEN.
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FA HIC-1-isoform2
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SY Hic-1; HIC1; hypermethylated in cancer 1; Hypermethylated in cancer 1 protein; ZBTB29; Zinc finger and BTB domain containing protein 29.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G013834 HIC1; HGNC: HIC1.
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CL C0001; CH; 2.3.4.17.1.2.
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SZ 714 AA; 74.5 kDa (calc.).
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SQ MLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD
SQ NLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIP
SQ DLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYPSPVGPPPPP
SQ AAEPPSGPEAAVNTHCAELYASGPGPAAALCASERRCSPLCGLDLSKKSPPGSAAPERPL
SQ AERELPPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKLEEAAPPSDPFRGGSGSPGPEPP
SQ GRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDAAVSPGGPPLGLAPPPR
SQ YPGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVC
SQ IPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGG
SQ LGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLG
SQ LKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAA
SQ GAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTH
SQ FLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT
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SC Swiss-Prot#Q14526-2
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FT 18 134 
PF00651; BTB/POZ domain.
FT 28 91 
PS50097; BTB.
FT 28 134 
SM00225; BTB_4.
FT 54 577 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 418 440 
SM00355; c2h2final6.
FT 418 445 
PS50157; ZINC_FINGER_C2H2_2.
FT 488 510 
PF00096; zf-C2H2.
FT 488 510 
SM00355; c2h2final6.
FT 488 515 
PS50157; ZINC_FINGER_C2H2_2.
FT 516 538 
PF00096; zf-C2H2.
FT 516 538 SM00355; c2h2final6.
FT 516 543 PS50157; ZINC_FINGER_C2H2_2.
FT 544 566 PF00096; zf-C2H2.
FT 544 566 SM00355; c2h2final6.
FT 544 571 PS50157; ZINC_FINGER_C2H2_2.
FT 572 594 PF00096; zf-C2H2.
FT 572 594 SM00355; c2h2final6.
FT 572 595 PS50157; ZINC_FINGER_C2H2_2.
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SF contains five Krueppel-like C2H2 zinc fingers and a N-terminal dimerization and autonomous repression domain called BTB/POZ (protein-protein interaction domain) [4];
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CP detection of endogenous HIC1 proteins in the DAOY medulloblastoma cell line [4].
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FF zinc fingers 3 and 4 bind a GGCA core motif [4];
FF the BTB/POZ domain inhibits the binding of full-length HIC1 to a single site but mediates cooperative binding to a probe containing five concatemerized binding sites [4];
FF repressor;
FF transcription is positively regulated by wt p53 [1] [2];
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IN T05222 CtBP1; human, Homo sapiens.
IN T06040 CtBP2; human, Homo sapiens.
IN T22418 MTA-1-long; human, Homo sapiens.
IN T33892 MTA-1; Mammalia.
IN T19318 TCF-4-isoform8; human, Homo sapiens.
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MX M01072 V$HIC1_02.
MX M01073 V$HIC1_03.
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BS R18235.
BS R18236.
BS R18237.
BS R18238.
BS R18239.
BS R18240.
BS R18241.
BS R18242.
BS R18243.
BS R18244.
BS R18245.
BS R18246.
BS R18247.
BS R18248.
BS R18249.
BS R18250.
BS R18251.
BS R18252.
BS R18253.
BS R18254.
BS R18255.
BS R18256.
BS R18257.
BS R18258.
BS R18259.
BS R18260.
BS R18261.
BS R18262.
BS R18263.
BS R18264.
BS R18265.
BS R18266.
BS R18267.
BS R18268.
BS R18269.
BS R18270.
BS R18271.
BS R18272.
BS R18273.
BS R18276.
BS R18277.
BS R18278.
BS R18279.
BS R18280.
BS R18281.
BS R18282.
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DR TRANSPATH: MO000045565.
DR EMBL: L41919;
DR UniProtKB: Q14526-2;
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RN [1]; RE0025443.
RX PUBMED: 11073960.
RA Guerardel C., Deltour S., Pinte S., Monte D., Begue A., Godwin A. K., Leprince D.
RT Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53.
RL J. Biol. Chem. 276:3078-3089 (2001).
RN [2]; RE0025444.
RX PUBMED: 7585125.
RA Wales M. M., Biel M. A., el Deiry W., Nelkin B. D., Issa J. P., Cavenee W. K., Kuerbitz S. J., Baylin S. B.
RT p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.
RL Nat. Med. 1:570-577 (1995).
RN [3]; RE0067182.
RX PUBMED: 20547755.
RA Van Rechem C., Boulay G., Pinte S., Stankovic-Valentin N., Guerardel C., Leprince D.
RT Differential regulation of HIC1 target genes by CtBP and NuRD, via an Acetylation/SUMOylation switch, in quiescent versus proliferating cells.
RL Mol. Cell. Biol. 30:4045-4059 (2010).
RN [4]; RE0035538.
RX PUBMED: 15231840.
RA Pinte S., Stankovic-Valentin N., Deltour S., Rood B. R., Guerardel C., Leprince D.
RT The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.
RL J. Biol. Chem. 279:38313-38324 (2004).
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