AC T08240
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ID T08240
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DT 06.10.2005 (created); elf.
DT 09.12.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA TORC2
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SY TORC-2; TORC2; transducer of regulated cAMP response element-binding protein (CREB) 2; Transducer of regulated CREB protein 2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G021414 CRTC2; HGNC: Crtc2.
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CP predominantly observed in B and T lymphocytes [1].
EX human, Homo sapiens,B-lymphocyte,,adult; very high; RT-PCR; total RNA; [1].
EX human, Homo sapiens,T-lymphocyte,,adult; very high; RT-PCR; total RNA; [1].
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FF cytoplasmic coactivator that enhances cellular gene expression via an interaction with CREB basic region/leucin zipper DNA-binding domain [3];
FF coactivator [1];
FF transducer of regulated CREB activity [1];
FF key regulator of fasting glucose metabolism [3];
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IN T00163 CREB-A; human, Homo sapiens.
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MX M07341 V$TORC2_Q3.
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BS R18283.
BS R63413.
BS R63527.
BS R63447.
BS R63477.
BS R63594.
BS R63619.
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DR TRANSPATH: MO000056457.
DR UniProtKB: Q53ET0; Q6UUV8_HUMAN.
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RN [1]; RE0035549.
RX PUBMED: 14536081.
RA Conkright M. D., Canettieri G., Screaton R., Guzman E., Miraglia L., Hogenesch J. B., Montminy M.
RT TORCs: transducers of regulated CREB activity.
RL Mol. Cell 12:413-423 (2003).
RN [2]; RE0062685.
RX PUBMED: 15778465.
RA Benzinger A., Muster N., Koch H. B., Yates JR 3. r. d., Hermeking H.
RT Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.
RL Mol. Cell. Proteomics 4:785-795 (2005).
RN [3]; RE0035548.
RX PUBMED: 16148943.
RA Koo S. H., Flechner L., Qi L., Zhang X., Screaton R. A., Jeffries S., Hedrick S., Xu W., Boussouar F., Brindle P., Takemori H., Montminy M.
RT The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.
RL Nature 437:1109-1111 (2005).
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