AC T08317
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ID T08317
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DT 19.12.2005 (created); ili.
DT 27.08.2013 (updated); sla.
CO Copyright (C), QIAGEN.
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FA PU.1-xbb1
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SY B1; NF-betaA; NF-JB; PU.1; PUrine-box binding factor 1; Spi-1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005728 Spi1.
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CL C0016; ETS.
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SZ 266 AA; 30.7 kDa (cDNA) (calc.).
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SQ MEGFSLTAPPSDDLVTYDSELYQRPMHDYYSFVGSDGESHSDHYWDFSAHHVHNNEFENF
SQ PENHFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHTGLSHQVSYMPRMCFPYQTLS
SQ PAHQQSSDEEEGERQSPPLEVSDGEADGLEPGPGLLHGETGSKKKIRLYQFLLDLLRSGD
SQ MKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKV
SQ KKKLTYQFSGEVLGRGGLAERRLPPH
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SC translated from EMBL:L03215
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FT 1 75 
trans-activation domain, interacting with Rb and TBP [2].
FT 123 261 
DNA binding domain [1].
FT 165 251 
PF00178; Ets-domain.
FT 165 253 
SM00413; etsneu2.
FT 166 249 
PS50061; ETS_DOMAIN_3.
FT 168 240 
PS50140; HSF_ETS.
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IN T25707 FUS-L; human, Homo sapiens.
IN T26833 p54NRB-isoform1; mouse, Mus musculus.
IN T18332 TLS; mouse, Mus musculus.
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MX M00971 V$ETS_Q6.
MX M01172 V$PU1_Q4.
MX M00658 V$PU1_Q6.
MX M02896 V$SFPI1_04.
MX M01203 V$SPI1_01.
MX M02031 V$SPI1_Q5.
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BS R13565.
BS R04722.
BS R14192.
BS R08122.
BS R02982.
BS R01068.
BS R15375.
BS R15376.
BS R13573.
BS R03675.
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DR TRANSPATH: MO000056619.
DR EMBL: L03215;
DR UniProtKB: P17433;
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RN [1]; RE0000109.
RX PUBMED: 2180582.
RA Klemsz M. J., McKercher S. R., Celada A., van Beveren C., Maki R. A.
RT The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
RL Cell 61:113-124 (1990).
RN [2]; RE0002493.
RX PUBMED: 8434021.
RA Hagemeier C., Bannister A. J., Cook A., Kouzarides T.
RT The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB
RL Proc. Natl. Acad. Sci. USA 90:1580-1584 (1993).
RN [3]; RE0003064.
RX PUBMED: 1729611.
RA Pongubala J. M. R., Nagulapalli S., Klemsz M. J., McKercher S. R., Maki R. A., Atchison M. L.
RT PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity
RL Mol. Cell. Biol. 12:368-378 (1992).
RN [4]; RE0048122.
RX PUBMED: 9478924.
RA Hallier M., Lerga A., Barnache S., Tavitian A., Moreau-Gachelin F.
RT The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS.
RL J. Biol. Chem. 273:4838-4842 (1998).
RN [5]; RE0048130.
RX PUBMED: 8626664.
RA Hallier M., Tavitian A., Moreau-Gachelin F.
RT The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb.
RL J. Biol. Chem. 271:11177-11181 (1996).
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