AC T08493
XX
ID T08493
XX
DT 30.01.2006 (created); res.
DT 11.03.2010 (updated); jig.
CO Copyright (C), QIAGEN.
XX
FA c-Fos
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SY c-Fos; FBJ osteosarcoma oncogene.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002143 Fos.
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CL C0008; bZIP.
XX
SZ 380 AA; 40.9 kDa (cDNA) (calc.), 55-65 kDa (SDS)
XX
SQ MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNTQDFCADLSVSSANF
SQ IPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGLPTPSTGAYARAGVVKTMSGGRA
SQ QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
SQ TEIANLLKEKEKLEFILAAHRPACKIPNDLGFPEEMSVTSLDLTGGLPEATTPESEEAFT
SQ LPLLNDPEPKPSLEPVKNISNMELKAEPFDDFLFPASSRPSGSETARSVPDVDLSGSFYA
SQ ADWEPLHSSSLGMGPMVTELEPLCTPVVTCTPSCTTYTSSFVFTYPEADSFPSCAAAHRK
SQ GSSSNEPSSDSLSSPTLLAL
XX
SC Swiss-Prot#P12841
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FT 1 47 
transcription activation module FAM1 [8].
FT 47 81 
transcription activation module FAM2 [8].
FT 63 74 
HOB1-N [8].
FT 81 142 
inhibitory domain ID1 containing inhibitory motif IM1 (GRRGK) [8].
FT 135 199 
PF00170; bZIP transcription factor.
FT 135 199 
SM00338; brlzneu.
FT 137 200 
PS50217; BZIP.
FT 210 244 
transcription activation module FAM3 [8].
FT 244 308 
transcription activation module FAM4 [8].
FT 267 276 
HOB2 [9].
FT 308 380 transcription activation module FAM5 [8].
XX
IN T08466 c-Jun; rat, Rattus norvegicus.
IN T08587 c-Jun; mouse, Mus musculus.
IN T23077 CHOP-10; Mammalia.
IN T08590 JunB; mouse, Mus musculus.
IN T08536 JunD; mouse, Mus musculus.
XX
MX M00172 V$AP1FJ_Q2.
MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M03815 V$CFOS_Q6.
XX
BS R08094.
BS R05033.
BS R05083.
BS R05089.
BS R05091.
BS R05093.
BS R05035.
BS R05071.
BS R04330.
XX
DR TRANSPATH: MO000058978.
DR EMBL: U02631;
DR EMBL: X06769;
DR UniProtKB: P12841;
XX
RN [1]; RE0016689.
RX PUBMED: 7648395.
RA Bassuk A. G., Leiden J. M.
RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells.
RL Immunity 3:223-237 (1995).
RN [2]; RE0046520.
RX PUBMED: 10567391.
RA Kabe Y., Goto M., Shima D., Imai T., Wada T., Morohashi K., Shirakawa M., Hirose S., Handa H.
RT The role of human MBF1 as a transcriptional coactivator
RL J. Biol. Chem. 274:34196-202 (1999).
RN [3]; RE0047533.
RX PUBMED: 10523647.
RA Ubeda M., Vallejo M., Habener J. F.
RT CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins.
RL Mol. Cell. Biol. 19:7589-7599 (1999).
RN [4]; RE0047872.
RX PUBMED: 9685505.
RA Yamaguchi Y., Wada T., Suzuki F., Takagi T., Hasegawa J., Handa H.
RT Casein kinase II interacts with the bZIP domains of several transcription factors.
RL Nucleic Acids Res. 26:3854-3861 (1998).
RN [5]; RE0049305.
RX PUBMED: 16055710.
RA Bossis G., Malnou C. E., Farras R., Andermarcher E., Hipskind R., Rodriguez M., Schmidt D., Muller S., Jariel-Encontre I., Piechaczyk M.
RT Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.
RL Mol. Cell. Biol. 25:6964-6979 (2005).
RN [6]; RE0054068.
RX PUBMED: 11925568.
RA Zhang J., Zhang D., McQuade J. S., Behbehani M., Tsien J. Z., Xu M.
RT c-fos regulates neuronal excitability and survival.
RL Nat. Genet. 30:416-420 (2002).
RN [7]; RE0066145.
RX PUBMED: 20053986.
RA Malnou C. E., Brockly F., Favard C., Moquet-Torcy G., Piechaczyk M., Jariel-Encontre I.
RT Heterodimerization with different Jun proteins controls c-Fos intranuclear dynamics and distribution.
RL J. Biol. Chem. 285:6552-6562 (2010).
RN [8]; RE0004823.
RX PUBMED: 7828584.
RA Brown H. J., Sutherland J. A., Cook A., Bannister A. J., Kouzarides T.
RT An inhibitor domain in c-Fos regulates activation domains containing the HOB1 motif
RL EMBO J. 14:124-131 (1995).
RN [9]; RE0004818.
RX PUBMED: 1516835.
RA Sutherland J. A., Cook A., Bannister A. J., Kouzarides T.
RT Conserved motifs in Fos and Jun define a new class of activation domain
RL Genes Dev. 6:1810-1819 (1992).
XX
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