AC T08726
XX
ID T08726
XX
DT 21.03.2006 (created); rad.
DT 10.02.2014 (updated); yre.
CO Copyright (C), QIAGEN.
XX
FA HDAC5-isoform1
XX
SY HD5; histone deacetylase 5; KIAA0600; NY-CO-9.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004770 HDAC5; HGNC: HDAC5.
XX
SZ 1122 AA; 122.0 kDa (cDNA) (calc.).
XX
SQ MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELR
SQ GALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQ
SQ QEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS
SQ TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKL
SQ PLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEI
SQ TGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ
SQ FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMST
SQ SSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATS
SQ MRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE
SQ LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEEDGEEEED
SQ CIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQ
SQ SSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQE
SQ TGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLP
SQ CGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAM
SQ GFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNF
SQ FPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVS
SQ AGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVS
SQ ALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGET
SQ EEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
XX
SC translated from EMBL:AF132608
XX
FT 91 1107 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 682 1028 
PF00850; Histone deacetylase domain.
XX
CP U2H7, U2H15 [5].
XX
IN T34300 BCOR-isoform2; human, Homo sapiens.
IN T34301 BCOR-S; human, Homo sapiens.
IN T08291 GATA-1-isoform1; mouse, Mus musculus.
XX
DR TRANSPATH: MO000079390.
DR EMBL: AB011172; AB011172.
DR EMBL: AF039691; AF039691.
DR EMBL: AF132608; AF132608.
DR UniProtKB: Q9UQL6; HDA5_HUMAN.
XX
RN [1]; RE0025804.
RX PUBMED: 14668799.
RA Watamoto K., Towatari M., Ozawa Y., Miyata Y., Okamoto M., Abe A., Naoe T., Saito H.
RT Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation.
RL Oncogene 22:9176-84 (2003).
RN [2]; RE0026599.
RX PUBMED: 10898795.
RA Huynh K. D., Fischle W., Verdin E., Bardwell V. J.
RT BCoR, a novel corepressor involved in BCL-6 repression.
RL Genes Dev. 14:1810-23 (2000).
RN [3]; RE0052069.
RX PUBMED: 12242305.
RA Zhang C. L., McKinsey T. A., Olson E. N.
RT Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation.
RL Mol. Cell. Biol. 22:7302-7312 (2002).
RN [4]; RE0053498.
RX PUBMED: 17823368.
RA Xu X., Ha C. H., Wong C., Wang W., Hausser A., Pfizenmaier K., Olson E. N., McKinsey T. A., Jin Z. G.
RT Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy.
RL Arterioscler. Thromb. Vasc. Biol. 27:2355-2362 (2007).
RN [5]; RE0053542.
RX PUBMED: 12019172.
RA Huang Y., Tan M., Gosink M., Wang K. K., Sun Y.
RT Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis.
RL Cancer Res. 62:2913-2922 (2002).
XX
//