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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T08726 XX ID T08726 XX DT 21.03.2006 (created); rad. DT 10.02.2014 (updated); yre. CO Copyright (C), QIAGEN. XX FA HDAC5-isoform1 XX SY HD5; histone deacetylase 5; KIAA0600; NY-CO-9. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004770 HDAC5; HGNC: HDAC5. XX SZ 1122 AA; 122.0 kDa (cDNA) (calc.). XX SQ MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELR SQ GALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQ SQ QEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS SQ TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKL SQ PLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEI SQ TGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ SQ FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMST SQ SSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATS SQ MRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE SQ LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEEDGEEEED SQ CIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQ SQ SSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQE SQ TGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLP SQ CGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAM SQ GFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNF SQ FPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVS SQ AGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVS SQ ALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGET SQ EEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL XX SC translated from EMBL:AF132608 XX FT 91 1107 PF00478; IMP dehydrogenase / GMP reductase domai. FT 682 1028 PF00850; Histone deacetylase domain. XX CP U2H7, U2H15 [5]. XX IN T34300 BCOR-isoform2; human, Homo sapiens. IN T34301 BCOR-S; human, Homo sapiens. IN T08291 GATA-1-isoform1; mouse, Mus musculus. XX DR TRANSPATH: MO000079390. DR EMBL: AB011172; AB011172. DR EMBL: AF039691; AF039691. DR EMBL: AF132608; AF132608. DR UniProtKB: Q9UQL6; HDA5_HUMAN. XX RN [1]; RE0025804. RX PUBMED: 14668799. RA Watamoto K., Towatari M., Ozawa Y., Miyata Y., Okamoto M., Abe A., Naoe T., Saito H. RT Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation. RL Oncogene 22:9176-84 (2003). RN [2]; RE0026599. RX PUBMED: 10898795. RA Huynh K. D., Fischle W., Verdin E., Bardwell V. J. RT BCoR, a novel corepressor involved in BCL-6 repression. RL Genes Dev. 14:1810-23 (2000). RN [3]; RE0052069. RX PUBMED: 12242305. RA Zhang C. L., McKinsey T. A., Olson E. N. RT Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. RL Mol. Cell. Biol. 22:7302-7312 (2002). RN [4]; RE0053498. RX PUBMED: 17823368. RA Xu X., Ha C. H., Wong C., Wang W., Hausser A., Pfizenmaier K., Olson E. N., McKinsey T. A., Jin Z. G. RT Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy. RL Arterioscler. Thromb. Vasc. Biol. 27:2355-2362 (2007). RN [5]; RE0053542. RX PUBMED: 12019172. RA Huang Y., Tan M., Gosink M., Wang K. K., Sun Y. RT Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis. RL Cancer Res. 62:2913-2922 (2002). XX //