AC T09019
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ID T09019
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DT 07.06.2006 (created); jag.
DT 11.12.2008 (updated); spi.
CO Copyright (C), QIAGEN.
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FA Mad3
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SY 4631412E13Rik; MAD3; Max dimerization protein 3; MXD3.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014366 Mxd3.
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CL C0012; bHLH-ZIP; 1.2.6.7.2.1.
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SZ 206 AA; 23.7 kDa (cDNA) (calc.).
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SQ MEPVASNIQVLLQAAEFLERREREAEHGYASLCPHHSPGTVCRRRKPPLQAPGALNSGRS
SQ VHNELEKRRRAQLKRCLEQLRQQMPLGVDCTRYTTLSLLRRARVHIQKLEEQEQQARRLK
SQ EKLRSKQQSLQQQLEQLQGLPGARERERLRADSLDSSGLSSERSDSDQEDLEVDVENLVF
SQ GTETELLQSFSAGREHSYSHSTCAWL
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SC SPTREMBL #Q60947
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FT 9 25 
Sin3-interacting domain (SID) [1].
FT 43 110 
PS50888; HLH.
FT 58 110 
PF00010; Helix-loop-helix DNA-binding domain.
FT 59 70 
basic region [1].
FT 63 115 
SM00353; finulus.
FT 71 108 
helix-loop-helix domain [1].
FT 109 137 
leucine zipper (LAL3) [1].
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FF expression represses transcription especially in combination with Max [1];
FF antagonize transcriptional activities of c-Myc [1];
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IN T05056 Max; human, Homo sapiens.
IN T09085 Max; Mammalia.
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DR TRANSPATH: MO000082622.
DR EMBL: U32394;
DR UniProtKB: Q80US8;
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RN [1]; RE0006786.
RX PUBMED: 8521822.
RA Hurlin P. J., Queva C., Koskinen P. J., Steingrimsson E., Ayer D. E., Copeland N. G., Jenkins N. A., Eisenman R. N.
RT Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
RL EMBO J. 14:5646-5659 (1995).
RN [2]; RE0050488.
RX PUBMED: 15121849.
RA Grinberg A. V., Hu C. D., Kerppola T. K.
RT Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells.
RL Mol. Cell. Biol. 24:4294-4308 (2004).
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