AC T09182
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ID T09182
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DT 02.08.2006 (created); jul.
DT 23.07.2012 (updated); pos.
CO Copyright (C), QIAGEN.
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FA Pax-5
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SY B-cell specific activator protein; BSAP; BSAP/PAX-5, B-cell Specific Activating Protein; mPax-5; mPax5; Pax-5; PAX5.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006533 Pax5.
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CL C0017; paired.
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SZ 391 AA; 42.2 kDa (cDNA) (calc.), 50 kDa (SDS) [1]
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SQ MDLEKNYPTPRTIRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV
SQ SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLA
SQ ERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
SQ ISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRV
SQ FERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLTSPTPADIGSSVPGPQSYP
SQ IVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRF
SQ PNPGLLGSPYYYSPAARGAAPPAAATAYDRH
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SC Swiss-Prot#Q02650
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FT 16 140 
PF00292; 'Paired box' domain.
FT 16 140 
SM00351; pax3.
FT 16 142 
PS51057; PAIRED_2.
FT 69 391 
PF00478; IMP dehydrogenase / GMP reductase domain.
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IN T08470 Daxx-isoform1; human, Homo sapiens.
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MX M00143 V$PAX5_01.
MX M00144 V$PAX5_02.
MX M03577 V$PAX5_Q6.
MX M00808 V$PAX_Q6.
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BS R17086.
BS R29655.
BS R08841.
BS R08842.
BS R29657.
BS R28953.
BS R16788.
BS R20634.
BS R37616.
BS R37617.
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DR TRANSPATH: MO000084310.
DR EMBL: M97013;
DR UniProtKB: Q02650;
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RN [1]; RE0002744.
RX PUBMED: 2116362.
RA Barberis A., Widenhorn K., Vitelli L., Busslinger M.
RT A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation
RL Genes Dev. 4:849-859 (1990).
RN [2]; RE0004022.
RX PUBMED: 8001125.
RA Bain G., Maandag E. C. R., Izon D. J., Amsen D., Kruisbeek A. M., Weintraub B. C., Krop I., Schlissel M. S., Feeney A. J., van Roon M., van der Falk M., te Riele H. P. J., Berns A., Murre C.
RT E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
RL Cell 79:885-892 (1994).
RN [3]; RE0004257.
RX PUBMED: 1685142.
RA Walther C., Guenet J. L., Simon D., Deutsch U., Jostes B., Goulding M. D., Plachov D., Balling R., Gruss P.
RT Pax: a murine multigene family of paired box-containing genes
RL Genomics 11:424-434 (1991).
RN [4]; RE0004263.
RX PUBMED: 7739566.
RA Czerny T., Busslinger M.
RT DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5)
RL Mol. Cell. Biol. 15:2858-2871 (1995).
RN [5]; RE0004279.
RX PUBMED: 1516825.
RA Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P., Maurer-Fogy I., Busslinger M.
RT Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis
RL Genes Dev. 6:1589-1607 (1992).
RN [6]; RE0004294.
RX PUBMED: 8001127.
RA Urbanek P., Wang Z.-Q., Fetka I., Wagner E. F., Busslinger M.
RT Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
RL Cell 79:901-912 (1994).
RN [7]; RE0004295.
RX PUBMED: 7777508.
RA Neurath M. F., Max E. E., Strober W.
RT Pax5 (BSAP) regulates the mrine immunoglobulin 3'a enhancer by suppressing binding of NF-aP, a protein that controls heavy chain transcription
RL Proc. Natl. Acad. Sci. USA 92:5336-5340 (1995).
RN [8]; RE0014313.
RX PUBMED: 8625814.
RA Song D. L., Chalepakis G., Gruss P., Joyner A. L.
RT Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene
RL Development 122:627-635 (1996).
RN [9]; RE0042428.
RX PUBMED: 11799127.
RA Emelyanov A. V., Kovac C. R., Sepulveda M. A., Birshtein B. K.
RT The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells
RL J. Biol. Chem. 277:11156-64 (2002).
RN [10]; RE0047965.
RX PUBMED: 10748034.
RA Kovac C. R., Emelyanov A., Singh M., Ashouian N., Birshtein B. K.
RT BSAP (Pax5)-importin alpha 1 (Rch1) interaction identifies a nuclear localization sequence.
RL J. Biol. Chem. 275:16752-16757 (2000).
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