AC T09193
XX
ID T09193
XX
DT 07.08.2006 (created); kau.
DT 13.12.2012 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA ALL1-isoform1
XX
SY ALL1; HRX; HTRX; MLL.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G001428 KMT2A; HGNC: KMT2A.
XX
CL C0070; CXXC; 2.6.1.0.4.1.
XX
SZ 3969 AA; 431.7 kDa (cDNA) (calc.).
XX
SQ MAHSCRWRFPARPGTTGGGGGGGRRGLGGXPRQRVPALLLPPGPPVGGGGPGAPPSPPAV
SQ AAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSGPALLRVGPGFDAALQVSA
SQ AIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SQ SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKD
SQ ISELPKGNKEDSLKKIKRTPSATFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIV
SQ RRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
SQ IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSR
SQ IIKTPRRFIEDEDYDPPIKIARLESTPNSRFSAPSCGSSEKSSAASQHSSQMSSDSSRSS
SQ SPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
SQ RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPAS
SQ TAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDNFRPPPLTPED
SQ VGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
SQ RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSL
SQ SISVSPLATSALNPTFTFPSHSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFT
SQ PGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SQ SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKI
SQ LIKKGRGNLEKTNLDLGPTAPSLEKEKTLCLSTPSSSTVKHSTSSIGSMLAQADKLPMTD
SQ KRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
SQ RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKA
SQ PQEPPVKKGRRSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWM
SQ PSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
SQ PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVP
SQ KTTPSEPKKKQPPPPESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPPVNKQENAGTLNIL
SQ STLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASS
SQ GHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNK
SQ CRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA
SQ KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYT
SQ CVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESI
SQ PSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINS
SQ DGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDH
SQ NYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPE
SQ LNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKN
SQ VHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDL
SQ IKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDC
SQ EDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPT
SQ SFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCR
SQ PLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYS
SQ RNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHL
SQ DGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTS
SQ RELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVK
SQ TLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNL
SQ KPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTV
SQ KVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSC
SQ QDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSY
SQ GEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASH
SQ NLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPED
SQ AGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNL
SQ LDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEG
SQ LGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPT
SQ VPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMD
SQ ADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQIS
SQ NAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTS
SQ VLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNP
SQ PSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTP
SQ SNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAP
SQ LLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPG
SQ HVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAI
SQ TAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQV
SQ SNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKT
SQ KRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSS
SQ QKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESI
SQ TEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRML
SQ GILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNF
SQ LASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHG
SQ RGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGN
SQ RARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCG
SQ AKKCRKFLN
XX
SC Swiss-Prot#Q03164-1
XX
FT 1 62 
missed in ref. [1].
FT 219 230 
PF02178; AT_hook.
FT 300 312 
PF02178; AT_hook.
FT 1147 1194 
PF02008; CXXC zinc finger.
FT 1147 1195 
PS51058; ZF_CXXC.
FT 1431 1482 
PS50016; ZF_PHD_2.
FT 1433 1480 
SM00249; PHD_3.
FT 1433 1482 
PF00628; PHD-finger.
FT 1479 1533 
PS50016; ZF_PHD_2.
FT 1481 1531 
SM00249; PHD_3.
FT 1483 1533 PF00628; PHD-finger.
FT 1566 1627 PS50016; ZF_PHD_2.
FT 1568 1625 SM00249; PHD_3.
FT 1568 1627 PF00628; PHD-finger.
FT 1603 1604 insertion GTE [1].
FT 1633 1767 SM00297; bromo_6.
FT 1703 1748 PS50014; BROMODOMAIN_2.
FT 1932 1978 SM00249; PHD_3.
FT 2023 2073 PF05964; F/Y-rich N-terminus.
FT 2030 2073 SM00541; FYRN.
FT 3666 3749 PF05965; F/Y rich C-terminus.
FT 3668 3753 SM00542; FYRC.
FT 3823 3951 PF00856; SET domain.
FT 3828 3949 PS50280; SET.
FT 3829 3951 SM00317; set_7.
FT 3953 3969 PS50868; POST_SET.
FT 3953 3969 SM00508; PostSET_3.
XX
IN T02113 TAFII31; human, Homo sapiens.
XX
DR TRANSPATH: MO000084463.
DR EMBL: L04284;
DR EMBL: L04731;
DR UniProtKB: Q03164-1;
XX
RN [1]; RE0006532.
RX PUBMED: 1423625.
RA Gu Y., Nakamura T., Alder H., Prasad R., Canaani O., Cimino G., Croce C. M., Canaani E.
RT The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila thrthorax, to the AF-4 gene
RL Cell 71:701-708 (1992).
RN [2]; RE0006535.
RX PUBMED: 1423624.
RA Tkachuk D. C., Kohler S., Cleary M. L.
RT Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
RL Cell 71:691-700 (1992).
RN [3]; RE0047995.
RX PUBMED: 10821850.
RA Choi Y., Asada S., Uesugi M.
RT Divergent hTAFII31-binding motifs hidden in activation domains.
RL J. Biol. Chem. 275:15912-15916 (2000).
RN [4]; RE0062933.
RX PUBMED: 12482972.
RA Hsieh J. J., Ernst P., Erdjument-Bromage H., Tempst P., Korsmeyer S. J.
RT Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization.
RL Mol. Cell. Biol. 23:186-194 (2003).
RN [5]; RE0062956.
RX PUBMED: 14636557.
RA Hsieh J. J., Cheng E. H., Korsmeyer S. J.
RT Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.
RL Cell 115:293-303 (2003).
RN [6]; RE0062977.
RX PUBMED: 12393701.
RA Yokoyama A., Kitabayashi I., Ayton P. M., Cleary M. L., Ohki M.
RT Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties.
RL Blood 100:3710-3718 (2002).
XX
//