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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T09193 XX ID T09193 XX DT 07.08.2006 (created); kau. DT 13.12.2012 (updated); spk. CO Copyright (C), QIAGEN. XX FA ALL1-isoform1 XX SY ALL1; HRX; HTRX; MLL. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G001428 KMT2A; HGNC: KMT2A. XX CL C0070; CXXC; 2.6.1.0.4.1. XX SZ 3969 AA; 431.7 kDa (cDNA) (calc.). XX SQ MAHSCRWRFPARPGTTGGGGGGGRRGLGGXPRQRVPALLLPPGPPVGGGGPGAPPSPPAV SQ AAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSGPALLRVGPGFDAALQVSA SQ AIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR SQ SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKD SQ ISELPKGNKEDSLKKIKRTPSATFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIV SQ RRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI SQ IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSR SQ IIKTPRRFIEDEDYDPPIKIARLESTPNSRFSAPSCGSSEKSSAASQHSSQMSSDSSRSS SQ SPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS SQ RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPAS SQ TAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDNFRPPPLTPED SQ VGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN SQ RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSL SQ SISVSPLATSALNPTFTFPSHSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFT SQ PGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ SQ SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKI SQ LIKKGRGNLEKTNLDLGPTAPSLEKEKTLCLSTPSSSTVKHSTSSIGSMLAQADKLPMTD SQ KRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG SQ RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKA SQ PQEPPVKKGRRSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWM SQ PSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE SQ PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVP SQ KTTPSEPKKKQPPPPESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPPVNKQENAGTLNIL SQ STLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASS SQ GHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNK SQ CRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA SQ KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYT SQ CVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESI SQ PSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINS SQ DGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDH SQ NYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPE SQ LNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKN SQ VHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDL SQ IKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDC SQ EDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPT SQ SFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCR SQ PLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYS SQ RNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHL SQ DGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTS SQ RELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVK SQ TLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNL SQ KPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTV SQ KVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSC SQ QDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSY SQ GEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASH SQ NLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPED SQ AGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNL SQ LDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEG SQ LGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPT SQ VPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMD SQ ADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQIS SQ NAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTS SQ VLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNP SQ PSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTP SQ SNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAP SQ LLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPG SQ HVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAI SQ TAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQV SQ SNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKT SQ KRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSS SQ QKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESI SQ TEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRML SQ GILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNF SQ LASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHG SQ RGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGN SQ RARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCG SQ AKKCRKFLN XX SC Swiss-Prot#Q03164-1 XX FT 1 62 missed in ref. [1]. FT 219 230 PF02178; AT_hook. FT 300 312 PF02178; AT_hook. FT 1147 1194 PF02008; CXXC zinc finger. FT 1147 1195 PS51058; ZF_CXXC. FT 1431 1482 PS50016; ZF_PHD_2. FT 1433 1480 SM00249; PHD_3. FT 1433 1482 PF00628; PHD-finger. FT 1479 1533 PS50016; ZF_PHD_2. FT 1481 1531 SM00249; PHD_3. FT 1483 1533 PF00628; PHD-finger. FT 1566 1627 PS50016; ZF_PHD_2. FT 1568 1625 SM00249; PHD_3. FT 1568 1627 PF00628; PHD-finger. FT 1603 1604 insertion GTE [1]. FT 1633 1767 SM00297; bromo_6. FT 1703 1748 PS50014; BROMODOMAIN_2. FT 1932 1978 SM00249; PHD_3. FT 2023 2073 PF05964; F/Y-rich N-terminus. FT 2030 2073 SM00541; FYRN. FT 3666 3749 PF05965; F/Y rich C-terminus. FT 3668 3753 SM00542; FYRC. FT 3823 3951 PF00856; SET domain. FT 3828 3949 PS50280; SET. FT 3829 3951 SM00317; set_7. FT 3953 3969 PS50868; POST_SET. FT 3953 3969 SM00508; PostSET_3. XX IN T02113 TAFII31; human, Homo sapiens. XX DR TRANSPATH: MO000084463. DR EMBL: L04284; DR EMBL: L04731; DR UniProtKB: Q03164-1; XX RN [1]; RE0006532. RX PUBMED: 1423625. RA Gu Y., Nakamura T., Alder H., Prasad R., Canaani O., Cimino G., Croce C. M., Canaani E. RT The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila thrthorax, to the AF-4 gene RL Cell 71:701-708 (1992). RN [2]; RE0006535. RX PUBMED: 1423624. RA Tkachuk D. C., Kohler S., Cleary M. L. RT Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias RL Cell 71:691-700 (1992). RN [3]; RE0047995. RX PUBMED: 10821850. RA Choi Y., Asada S., Uesugi M. RT Divergent hTAFII31-binding motifs hidden in activation domains. RL J. Biol. Chem. 275:15912-15916 (2000). RN [4]; RE0062933. RX PUBMED: 12482972. RA Hsieh J. J., Ernst P., Erdjument-Bromage H., Tempst P., Korsmeyer S. J. RT Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. RL Mol. Cell. Biol. 23:186-194 (2003). RN [5]; RE0062956. RX PUBMED: 14636557. RA Hsieh J. J., Cheng E. H., Korsmeyer S. J. RT Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. RL Cell 115:293-303 (2003). RN [6]; RE0062977. RX PUBMED: 12393701. RA Yokoyama A., Kitabayashi I., Ayton P. M., Cleary M. L., Ohki M. RT Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties. RL Blood 100:3710-3718 (2002). XX //