AC T09204
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ID T09204
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DT 08.08.2006 (created); jul.
DT 10.10.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Pax-5-isoform1
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SY B-cell specific activator protein; BSAP; BSAP/PAX-5, B-cell Specific Activating Protein; hPax-5; hPax5; Pax-5; PAX5.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003921 PAX5; HGNC: PAX5.
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CL C0017; paired.
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SZ 391 AA; 42.1 kDa (cDNA) (calc.), 50 kDa (SDS) [1]
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SQ MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV
SQ SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLA
SQ ERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
SQ ISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRV
SQ FERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYP
SQ IVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRF
SQ PNPGLLGSPYYYSAAARGAAPPAAATAYDRH
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SC Swiss-Prot#Q02548
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FT 16 140 
PF00292; 'Paired box' domain.
FT 16 140 
SM00351; pax3.
FT 16 142 
PS51057; PAIRED_2.
FT 22 22 
Gln22 is crucial for contacts with c-Ets-1 [8].
FT 22 24 
beta-hairpin, interaction with c-Ets-1 [8].
FT 29 30 
contact the minor groove [8].
FT 51 58 
helix B, interaction with c-Ets-1 [8].
FT 62 62 
essential for major groove contact [8].
FT 62 75 
DNA recognition helix, helix C [8].
FT 69 391 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 76 92 linker between NTD and CTD [8].
FT 83 86 contact the minor groove [8].
FT 132 140 DNA recognition helix, helix F [8].
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IN T09187 Id2; human, Homo sapiens.
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MX M00143 V$PAX5_01.
MX M00144 V$PAX5_02.
MX M03577 V$PAX5_Q6.
MX M00808 V$PAX_Q6.
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BS R27457.
BS R02128.
BS R08517.
BS R38878.
BS R30718.
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DR TRANSPATH: MO000084578.
DR EMBL: AF268279; AF268279.
DR EMBL: M96944;
DR UniProtKB: Q02548;
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RN [1]; RE0002744.
RX PUBMED: 2116362.
RA Barberis A., Widenhorn K., Vitelli L., Busslinger M.
RT A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation
RL Genes Dev. 4:849-859 (1990).
RN [2]; RE0003103.
RX PUBMED: 1375324.
RA Kozmik Z., Wang S., Doerfler P., Adams B., Busslinger M.
RT The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP
RL Mol. Cell. Biol. 12:2662-2672 (1992).
RN [3]; RE0003116.
RX PUBMED: 8406007.
RA Czerny T., Schaffner G., Busslinger M.
RT DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site
RL Genes Dev. 7:2048-2061 (1993).
RN [4]; RE0004279.
RX PUBMED: 1516825.
RA Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P., Maurer-Fogy I., Busslinger M.
RT Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis
RL Genes Dev. 6:1589-1607 (1992).
RN [5]; RE0011183.
RX PUBMED: 8521821.
RA Stuart E. T., Haffner R., Oren M., Gruss P.
RT Loss of p53 function through PAX-mediated transcriptional repression
RL EMBO J. 14:5638-5645 (1995).
RN [6]; RE0016685.
RX PUBMED: 8804314.
RA Fitzsimmons D., Hodsdon W., Wheat W., Maira S. M., Wasylyk B., Hagman J.
RT Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter.
RL Genes Dev. 10:2198-2211 (1996).
RN [7]; RE0016687.
RX PUBMED: 10022910.
RA Wheat W., Fitzsimmons D., Lennox H., Krautkramer S. R., Gentile L. N., McIntosh L. P., Hagman J.
RT The highly conserved beta-hairpin of the paired DNA-binding domain is required for assembly of Pax-Ets ternary complexes.
RL Mol. Cell. Biol. 19:2231-2241 (1999).
RN [8]; RE0023824.
RX PUBMED: 11779502.
RA Garvie C. W., Hagman J., Wolberger C.
RT Structural studies of Ets-1/Pax5 complex formation on DNA.
RL Mol. Cell 8:1267-1276 (2001).
RN [9]; RE0047963.
RX PUBMED: 11134340.
RA Roberts E. C., Deed R. W., Inoue T., Norton J. D., Sharrocks A. D.
RT Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding.
RL Mol. Cell. Biol. 21:524-533 (2001).
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