TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T09204 XX ID T09204 XX DT 08.08.2006 (created); jul. DT 10.10.2012 (updated); mkl. CO Copyright (C), QIAGEN. XX FA Pax-5-isoform1 XX SY B-cell specific activator protein; BSAP; BSAP/PAX-5, B-cell Specific Activating Protein; hPax-5; hPax5; Pax-5; PAX5. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003921 PAX5; HGNC: PAX5. XX CL C0017; paired. XX SZ 391 AA; 42.1 kDa (cDNA) (calc.), 50 kDa (SDS) [1] XX SQ MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV SQ SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLA SQ ERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS SQ ISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRV SQ FERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYP SQ IVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRF SQ PNPGLLGSPYYYSAAARGAAPPAAATAYDRH XX SC Swiss-Prot#Q02548 XX FT 16 140 PF00292; 'Paired box' domain. FT 16 140 SM00351; pax3. FT 16 142 PS51057; PAIRED_2. FT 22 22 Gln22 is crucial for contacts with c-Ets-1 [8]. FT 22 24 beta-hairpin, interaction with c-Ets-1 [8]. FT 29 30 contact the minor groove [8]. FT 51 58 helix B, interaction with c-Ets-1 [8]. FT 62 62 essential for major groove contact [8]. FT 62 75 DNA recognition helix, helix C [8]. FT 69 391 PF00478; IMP dehydrogenase / GMP reductase domain. FT 76 92 linker between NTD and CTD [8]. FT 83 86 contact the minor groove [8]. FT 132 140 DNA recognition helix, helix F [8]. XX IN T09187 Id2; human, Homo sapiens. XX MX M00143 V$PAX5_01. MX M00144 V$PAX5_02. MX M03577 V$PAX5_Q6. MX M00808 V$PAX_Q6. XX BS R27457. BS R02128. BS R08517. BS R38878. BS R30718. XX DR TRANSPATH: MO000084578. DR EMBL: AF268279; AF268279. DR EMBL: M96944; DR UniProtKB: Q02548; XX RN [1]; RE0002744. RX PUBMED: 2116362. RA Barberis A., Widenhorn K., Vitelli L., Busslinger M. RT A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation RL Genes Dev. 4:849-859 (1990). RN [2]; RE0003103. RX PUBMED: 1375324. RA Kozmik Z., Wang S., Doerfler P., Adams B., Busslinger M. RT The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP RL Mol. Cell. Biol. 12:2662-2672 (1992). RN [3]; RE0003116. RX PUBMED: 8406007. RA Czerny T., Schaffner G., Busslinger M. RT DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site RL Genes Dev. 7:2048-2061 (1993). RN [4]; RE0004279. RX PUBMED: 1516825. RA Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P., Maurer-Fogy I., Busslinger M. RT Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis RL Genes Dev. 6:1589-1607 (1992). RN [5]; RE0011183. RX PUBMED: 8521821. RA Stuart E. T., Haffner R., Oren M., Gruss P. RT Loss of p53 function through PAX-mediated transcriptional repression RL EMBO J. 14:5638-5645 (1995). RN [6]; RE0016685. RX PUBMED: 8804314. RA Fitzsimmons D., Hodsdon W., Wheat W., Maira S. M., Wasylyk B., Hagman J. RT Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter. RL Genes Dev. 10:2198-2211 (1996). RN [7]; RE0016687. RX PUBMED: 10022910. RA Wheat W., Fitzsimmons D., Lennox H., Krautkramer S. R., Gentile L. N., McIntosh L. P., Hagman J. RT The highly conserved beta-hairpin of the paired DNA-binding domain is required for assembly of Pax-Ets ternary complexes. RL Mol. Cell. Biol. 19:2231-2241 (1999). RN [8]; RE0023824. RX PUBMED: 11779502. RA Garvie C. W., Hagman J., Wolberger C. RT Structural studies of Ets-1/Pax5 complex formation on DNA. RL Mol. Cell 8:1267-1276 (2001). RN [9]; RE0047963. RX PUBMED: 11134340. RA Roberts E. C., Deed R. W., Inoue T., Norton J. D., Sharrocks A. D. RT Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding. RL Mol. Cell. Biol. 21:524-533 (2001). XX //