AC T09275
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ID T09275
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DT 30.08.2006 (created); sri.
DT 07.04.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA PUR1
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SY CAGER-1; PUR-alpha; pura; purine-rich single- stranded DNA-binding protein alpha; ssCRE-BP; transcriptional activator protein pur-alpha.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004539 Pura.
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CL C0015; HMG.
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SZ 321 AA; 34.9 kDa (calc.).
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SQ MADRDSGSEQGGAALGSGGSLGHPGSGSGSGGGGGGGGGGGGSGGGGGAPGGLQHETQEL
SQ ASKRVDIQNKRFYLDVKQNAKGRFLKIAEVGAGGNKSRLTLSMSVAVEFRDYLGDFIEHY
SQ AQLGPSQPPDLAQAQDEPRRALKSEFLVRENRKYYMDLKENQRGRFLRIRQTVNRGPGLG
SQ STQGQTIALPAQGLIEFRDALAKLIDDYGVEEEPAELPEGTSLTVDNKRFFFDVGSNKYG
SQ VFMRVSEVKPTYRNSITVPYKVWAKFGHTFCKYSEEMKKIQEKQREKRAACEQLHQQQQQ
SQ QQEETTAATLLLQGEEEGEED
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SC translated from EMBL #U02098
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FT 31 48 
glycine-rich region (17/18) [3].
FT 51 300 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 57 277 
PF04845; PurA ssDNA and RNA-binding protein.
FT 59 121 
SM00712; PUR.
FT 65 88 
acid class I repeat (probably part of DNA-binding domain) [3].
FT 106 130 
acid class II repeat (probably part of DNA-binding domain) [3].
FT 141 209 
SM00712; PUR.
FT 147 169 
acid class I repeat (probably part of DNA-binding domain) [3].
FT 194 219 
acid class II repeat (probably part of DNA-binding domain) [3].
FT 217 278 
SM00712; PUR.
FT 223 245 acid class I repeat (probably part of DNA-binding domain) [3].
FT 250 277 alpha helical region [3].
FT 296 302 glutamine-rich region (7/7) [3].
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IN T05172 PUR-beta; mouse, Mus musculus.
IN T01124 TEF-1; mouse, Mus musculus.
IN T02496 YB-1; mouse, Mus musculus.
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MX M01721 V$PUR1_Q4.
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BS R67022.
BS R26857.
BS R57271.
BS R12761.
BS R26185.
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DR TRANSPATH: MO000085934.
DR EMBL: AF017631;
DR EMBL: U02098;
DR UniProtKB: P42669;
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RN [1]; RE0011395.
RX PUBMED: 7592647.
RA Johnson E. M., Chen P.-L., Krackmarov C. P., Barr S. M., Kanovsky M., Ma Z.-W., Lee W.-H.
RT Association of human Puralpha with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Puralpha recognition element
RL J. Biol. Chem. 270:24352-24360 (1995).
RN [2]; RE0017923.
RX PUBMED: 7959008.
RA Ma Z. W., Bergemann A. D., Johnson E. M.
RT Conservation in human and mouse Pur alpha of a motif common to several proteins involved in initiation of DNA replication
RL Gene 149:311-314 (1994).
RN [3]; RE0017924.
RX PUBMED: 9334258.
RA Kelm RJ J. r., Elder P. K., Strauch A. R., Getz M. J.
RT Sequence of cDNAs encoding components of vascular actin single-stranded DNA-binding factor 2 establish identity to Puralpha and Purbeta
RL J. Biol. Chem. 272:26727-26733 (1997).
RN [4]; RE0017925.
RX PUBMED: 11751932.
RA Carlini L. E., Getz M. J., Strauch A. R., Kelm RJ J. r.
RT Cryptic MCAT enhancer regulation in fibroblasts and smooth muscle cells. Suppression of TEF-1 mediated activation by the single-stranded DNA-binding proteins, Pur alpha, Pur beta, and MSY1
RL J. Biol. Chem. 277:8682-8692 (2002).
RN [5]; RE0017928.
RX PUBMED: 7739527.
RA Sun S., Stoflet E. S., Cogan J. G., Strauch A. R., Getz M. J.
RT Negative regulation of the vascular smooth muscle alpha-actin gene in fibroblasts and myoblasts: disruption of enhancer function by sequence-specific single-stranded-DNA-binding proteins.
RL Mol. Cell. Biol. 15:2429-2436 (1995).
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