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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T09287 XX ID T09287 XX DT 01.09.2006 (created); jag. DT 09.09.2014 (updated); spk. CO Copyright (C), QIAGEN. XX FA MITF-M XX SY bw; Mi; Microphthalmia; microphthalmia-associated transcription factor; MITF; VIT; vitiligo; wh. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G002682 Mitf. XX CL C0012; bHLH-ZIP; 1.2.6.1.4.9. XX SZ 419 AA; 46.8 kDa (cDNA) (calc.). XX SQ MLEMLEYSHYQVQTHLENPTKYHIQQAQRHQVKQYLSTTLANKHASQVLSSPCPNQPGDH SQ AMPPVPGSSAPNSPMAMLTLNSNCEKEAFYKFEEQSRAESECPGMNTHSRASCMQMDDVI SQ DDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYSNQGLPPPGLTISNSCPANLPN SQ IKRELTACIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMR SQ WNKGTILKASVDYIRKLQREQQRAKDLENRQKKLEHANRHLLLRVQELEMQARAHGLSLI SQ PSTGLCSPDLVNRIIKQEPVLENCSQELVQHQADLTCTTTLDLTDGTITFTNNLGTMPES SQ SPAYSIPRKMGSNLEDILMDDALSPVGVTDPLLSSVSPGASKTSSRRSSMSAEETEHAC XX SC translated from EMBL #Z23066 XX FT 3 295 PF00478; IMP dehydrogenase / GMP reductase domain. FT 186 191 missing in splice variant [3]. FT 193 297 interacts with Otx2 [4]. FT 202 258 PS50888; HLH. FT 205 258 PF00010; Helix-loop-helix DNA-binding domain. FT 210 263 SM00353; finulus. XX IN T18332 TLS; mouse, Mus musculus. IN T25735 TLS; mouse, Mus musculus. XX MX M01034 V$EBOX_Q6_01. MX M07050 V$MITF_Q4. MX M02099 V$MITF_Q6. MX M01029 V$TFE_Q6. XX BS R15442. BS R15497. BS R15757. BS R16099. BS R15500. BS R15501. BS R16110. BS R16094. BS R16095. BS R16096. BS R16111. BS R16093. BS R11046. BS R15422. BS R15425. BS R15421. BS R15424. BS R15758. BS R15760. XX DR TRANSPATH: MO000086132. DR EMBL: L22958; DR EMBL: Z23066; DR UniProtKB: Q08874-8; MITF_MOUSE. XX RN [1]; RE0003422. RX PUBMED: 7958932. RA Hemesath T. J., Steingrimsson E., McGill G., Hansen M. J., Vaught J., Hodgkinson C. A., Arnheiter H., Copeland N. G., Jenkins N. A., Fisher D. E. RT microphthalamia, a critical factor in melanocyte development, defines a discrete transcription factor family RL Genes Dev. 8:2770-2780 (1994). RN [2]; RE0003423. RX PUBMED: 8407885. RA Hughes M. J., Lingrel J. B., Krakowsky J. M., Anderson K. P. RT A helix-loop-helix transcription factor-like gene is located at the mi locus RL J. Biol. Chem. 268:20687-20690 (1993). RN [3]; RE0003424. RX PUBMED: 8343963. RA Hodgkinson C. A., Moore K. J., Nakayama A., Steingrimsson E., Copeland N. G., Jenkins A. N., Arnheiter H. RT Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel bHLH-Zip protein RL Cell 74:395-404 (1993). RN [4]; RE0024922. RX PUBMED: 12663655. RA Martinez-Morales J. R., Dolez V., Rodrigo I., Zaccarini R., Leconte L., Bovolenta P., Saule S. RT OTX2 activates the molecular network underlying retina pigment epithelium differentiation. RL J. Biol. Chem. 278:21721-21731 (2003). RN [5]; RE0066852. RX PUBMED: 20177067. RA Hoshino T., Matsuda M., Yamashita Y., Takehara M., Fukuya M., Mineda K., Maji D., Ihn H., Adachi H., Sobue G., Funasaka Y., Mizushima T. RT Suppression of melanin production by expression of HSP70. RL J. Biol. Chem. 285:13254-13263 (2010). XX //