AC T09287
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ID T09287
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DT 01.09.2006 (created); jag.
DT 09.09.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA MITF-M
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SY bw; Mi; Microphthalmia; microphthalmia-associated transcription factor; MITF; VIT; vitiligo; wh.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002682 Mitf.
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CL C0012; bHLH-ZIP; 1.2.6.1.4.9.
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SZ 419 AA; 46.8 kDa (cDNA) (calc.).
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SQ MLEMLEYSHYQVQTHLENPTKYHIQQAQRHQVKQYLSTTLANKHASQVLSSPCPNQPGDH
SQ AMPPVPGSSAPNSPMAMLTLNSNCEKEAFYKFEEQSRAESECPGMNTHSRASCMQMDDVI
SQ DDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYSNQGLPPPGLTISNSCPANLPN
SQ IKRELTACIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMR
SQ WNKGTILKASVDYIRKLQREQQRAKDLENRQKKLEHANRHLLLRVQELEMQARAHGLSLI
SQ PSTGLCSPDLVNRIIKQEPVLENCSQELVQHQADLTCTTTLDLTDGTITFTNNLGTMPES
SQ SPAYSIPRKMGSNLEDILMDDALSPVGVTDPLLSSVSPGASKTSSRRSSMSAEETEHAC
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SC translated from EMBL #Z23066
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FT 3 295 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 186 191 
missing in splice variant [3].
FT 193 297 
interacts with Otx2 [4].
FT 202 258 
PS50888; HLH.
FT 205 258 
PF00010; Helix-loop-helix DNA-binding domain.
FT 210 263 
SM00353; finulus.
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IN T18332 TLS; mouse, Mus musculus.
IN T25735 TLS; mouse, Mus musculus.
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MX M01034 V$EBOX_Q6_01.
MX M07050 V$MITF_Q4.
MX M02099 V$MITF_Q6.
MX M01029 V$TFE_Q6.
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BS R15442.
BS R15497.
BS R15757.
BS R16099.
BS R15500.
BS R15501.
BS R16110.
BS R16094.
BS R16095.
BS R16096.
BS R16111.
BS R16093.
BS R11046.
BS R15422.
BS R15425.
BS R15421.
BS R15424.
BS R15758.
BS R15760.
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DR TRANSPATH: MO000086132.
DR EMBL: L22958;
DR EMBL: Z23066;
DR UniProtKB: Q08874-8; MITF_MOUSE.
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RN [1]; RE0003422.
RX PUBMED: 7958932.
RA Hemesath T. J., Steingrimsson E., McGill G., Hansen M. J., Vaught J., Hodgkinson C. A., Arnheiter H., Copeland N. G., Jenkins N. A., Fisher D. E.
RT microphthalamia, a critical factor in melanocyte development, defines a discrete transcription factor family
RL Genes Dev. 8:2770-2780 (1994).
RN [2]; RE0003423.
RX PUBMED: 8407885.
RA Hughes M. J., Lingrel J. B., Krakowsky J. M., Anderson K. P.
RT A helix-loop-helix transcription factor-like gene is located at the mi locus
RL J. Biol. Chem. 268:20687-20690 (1993).
RN [3]; RE0003424.
RX PUBMED: 8343963.
RA Hodgkinson C. A., Moore K. J., Nakayama A., Steingrimsson E., Copeland N. G., Jenkins A. N., Arnheiter H.
RT Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel bHLH-Zip protein
RL Cell 74:395-404 (1993).
RN [4]; RE0024922.
RX PUBMED: 12663655.
RA Martinez-Morales J. R., Dolez V., Rodrigo I., Zaccarini R., Leconte L., Bovolenta P., Saule S.
RT OTX2 activates the molecular network underlying retina pigment epithelium differentiation.
RL J. Biol. Chem. 278:21721-21731 (2003).
RN [5]; RE0066852.
RX PUBMED: 20177067.
RA Hoshino T., Matsuda M., Yamashita Y., Takehara M., Fukuya M., Mineda K., Maji D., Ihn H., Adachi H., Sobue G., Funasaka Y., Mizushima T.
RT Suppression of melanin production by expression of HSP70.
RL J. Biol. Chem. 285:13254-13263 (2010).
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