AC T09490
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ID T09490
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DT 16.10.2006 (created); apk.
DT 20.11.2008 (updated); mka.
CO Copyright (C), QIAGEN.
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FA Ikaros-isoform1
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SY Ik-1; Ik1; Ikaros 1; LyF-1; lymphoid transcription factor 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004705 IKZF1; HGNC: IKZF1.
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CL C0001; CH; 2.3.4.4.1.1.
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SZ 519 AA; 57.5 kDa (cDNA) (calc.).
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SQ MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVE
SQ TQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCD
SQ ICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNY
SQ ACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVI
SQ KEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYE
SQ KENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPR
SQ SNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAP
SQ HARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIH
SQ MGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS
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SC translated from EMBL #U40462
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FT 117 139 
SM00355; c2h2final6.
FT 117 144 
PS50157; ZINC_FINGER_C2H2_2.
FT 145 167 
PF00096; zf-C2H2.
FT 145 167 
SM00355; c2h2final6.
FT 145 172 
PS50157; ZINC_FINGER_C2H2_2.
FT 173 195 
PF00096; zf-C2H2.
FT 173 195 
SM00355; c2h2final6.
FT 173 200 
PS50157; ZINC_FINGER_C2H2_2.
FT 201 224 
PF00096; zf-C2H2.
FT 201 224 
SM00355; c2h2final6.
FT 201 229 PS50157; ZINC_FINGER_C2H2_2.
FT 462 484 SM00355; c2h2final6.
FT 490 514 SM00355; c2h2final6.
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FF Ikaros-isoform1 plays a significant positive role in STAT4 gene expression [3];
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IN T09170 CtBP1-isoform1; human, Homo sapiens.
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MX M00086 V$IK1_01.
MX M00087 V$IK2_01.
MX M00088 V$IK3_01.
MX M07260 V$IK_Q5_01.
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DR TRANSPATH: MO000089251.
DR EMBL: U40462;
DR UniProtKB: Q13422-1;
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RN [1]; RE0013555.
RX PUBMED: 8964602.
RA Nietfeld W., Meyerhans A.
RT Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1.
RL Immunol. Lett. 49:139-141 (1996).
RN [2]; RE0026561.
RX PUBMED: 10766745.
RA Koipally J., Georgopoulos K.
RT Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
RL J. Biol. Chem. 275:19594-602 (2000).
RN [3]; RE0048537.
RX PUBMED: 16081070.
RA Yap W. H., Yeoh E., Tay A., Brenner S., Venkatesh B.
RT STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells.
RL FEBS Lett. 579:4470-4478 (2005).
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