AC T09961
XX
ID T09961
XX
DT 29.11.2006 (created); din.
DT 29.11.2006 (updated); din.
CO Copyright (C), QIAGEN.
XX
FA TFIIF-alpha
XX
SY GTF2F1; RAP74; TFIIF-alpha; transcription initiation factor IIF, alpha subunit.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G006186 GTF2F1; HGNC: GTF2F1.
XX
SZ 517 AA; 58.3 kDa (cDNA) (calc.), 78 kDa, 80 kDa (SDS) [8] [7]
XX
SQ MAALGPSSQNVTEYVVRVPKNTTKKYNIMAFNAADKVNFATWNQARLERDLSNKKIYQEE
SQ EMPESGAGSEFNRKLREEARRKKYGIVLKEFRPEDQPWLLRVNGKSGRKFKGIKKGGVTE
SQ NTSYYIFTQCPDGAFEAFPVHNWYNFTPLARHRTLTAEEAEEEWERRNKVLNHFSIMQQR
SQ RLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPL
SQ AKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKG
SQ VDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSA
SQ FFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAA
SQ KRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTK
SQ KTGLSSEQTVNVLAQILKRLNPERKMINDKMHFSLKE
XX
SC Swiss-Prot#P35269
XX
FT 1 120 
binding to TAF(II)250 [1].
FT 1 170 
suggested globular domain [6].
FT 1 517 
PF05793; Transcription initiation factor IIF, alph.
FT 62 171 
interaction wih TFIIF-beta [10].
FT 357 517 
suggested globular domain, essential for full activity [6].
FT 357 517 
suggested globular domain, essential for full activity [10].
XX
IN T08487 AR-isoform1; human, Homo sapiens.
XX
DR TRANSPATH: MO000093589.
DR EMBL: X64002;
DR EMBL: X64037;
DR UniProtKB: P35269;
XX
RN [1]; RE0005590.
RX PUBMED: 7590250.
RA Ruppert S., Tjian R.
RT Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation
RL Genes Dev. 9:2747-2755 (1995).
RN [2]; RE0005736.
RX PUBMED: 8106390.
RA Zhu H., Joliot V., Prywes R.
RT Role of transcription factor TRIIF in serum response factor-activated transcription
RL J. Biol. Chem. 269:3489-3497 (1994).
RN [3]; RE0005737.
RX PUBMED: 7961996.
RA Kitajima S., Chibazakura T., Yonaha M., Yasukochi Y.
RT Regulation of the human general transcription initiation factor TFIIF by phosphorylation
RL J. Biol. Chem. 269:29970-29977 (1994).
RN [4]; RE0005739.
RX PUBMED: 7854423.
RA Joliot V., Demma M., Prywes R.
RT Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor
RL Nature 373:632-635 (1995).
RN [5]; RE0005740.
RX PUBMED: 1734283.
RA Aso T., Vasavada H. A., Kawaguchi T., Germino F. J., Ganguly S., Kitajima S., Weissman S. M., Yasukochi Y.
RT Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF
RL Nature 335:461-464 (1992).
RN [6]; RE0005741.
RX PUBMED: 1734284.
RA Finkelstein A., Kostrub C. F., Li J., Chavez D. P., Wang B. Q., Fang S. M., Greenblatt J., Burton Z. F.
RT A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II
RL Nature 355:464-467 (1992).
RN [7]; RE0005750.
RX PUBMED: 2180931.
RA Flores O., Ha I., Reinberg D.
RT Factors involved in specific transcription by mammalian RNA polymerase II. Purification and subunit composition of transcription factor IIE
RL J. Biol. Chem. 265:5629-5634 (1990).
RN [8]; RE0005751.
RX PUBMED: 2395645.
RA Kitajima S., Tanaka Y., Kawagachi T., Nagaoka T., Weissman S. M., Yasukochi Y.
RT A heteromeric transcription factor required for mammalian RNA polymerase II
RL Nucleic Acids Res. 18:4843-4849 (1990).
RN [9]; RE0005753.
RX PUBMED: 8376403.
RA Chang C.-H., Kostrub C. F., Burton Z. F.
RT RAP30/74 (transcription factor IIF) is required for promoter escape by RNA polymerase II
RL J. Biol. Chem. 268:20482-20489 (1993).
RN [10]; RE0005754.
RX PUBMED: 8441635.
RA Yonaha M., Aso T., Kobayashi Y., Vasavada H., Yasukochi Y., Weissman S. M., Kitajima S.
RT Domain structure of a human general transcription initiation factor, TFIIF
RL Nucleic Acids Res. 21:273-279 (1993).
RN [11]; RE0029221.
RX PUBMED: 9238003.
RA McEwan I. J., Gustafsson J.
RT Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF.
RL Proc. Natl. Acad. Sci. USA 94:8485-90 (1997).
XX
//