AC T10215
XX
ID T10215
XX
DT 02.02.2007 (created); sou.
DT 13.11.2009 (updated); spi.
CO Copyright (C), QIAGEN.
XX
FA TTF-1
XX
SY Homeobox protein Nkx-2.1; Nkx-2.1; Nkx2.1; T/EBP; thyroid nuclear factor 1; TTF-1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G004905 Nkx2-1.
XX
CL C0053; NK-2/Nkx; 3.1.2.14.1.1.
XX
SZ 372 AA; 38.6 kDa (cDNA) (calc.).
XX
SQ MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGH
SQ HGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDP
SQ RFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRF
SQ KQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGG
SQ GGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQSHAQQQAQQQAQAAQA
SQ AAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAGLQGQVSSLSHLNSSGSDYGA
SQ MSCSTLLYGRTW
XX
SC Swiss-Prot#P50220
XX
FT 159 219 
PS50071; HOMEOBOX_2.
FT 161 223 
SM00389; HOX_1.
FT 162 218 
PF00046; Homeobox domain.
FT 255 271 
NK-2 domain [6].
XX
IN T10208 GATA-6-isoform1; mouse, Mus musculus.
XX
MX M01312 V$NKX21_01.
MX M00432 V$TITF1_Q3.
MX M02034 V$TTF1_Q5.
MX M03891 V$TTF1_Q5_01.
MX M00794 V$TTF1_Q6.
XX
BS R04657.
BS R13152.
BS R13154.
BS R13155.
BS R13142.
BS R13143.
BS R13231.
BS R13249.
BS R13250.
BS R13251.
XX
DR TRANSPATH: MO000098127.
DR EMBL: U19755;
DR UniProtKB: P50220;
XX
RN [1]; RE0000467.
RX PUBMED: 1976511.
RA Guazzi S., Price M., de Felice M., Damante G., Mattei M., Di Lauro R.
RT Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity
RL EMBO J. 9:3631-3639 (1990).
RN [2]; RE0000696.
RX PUBMED: 1989905.
RA Avvedimento V. E., Musti A. M., Ueffing M., Obici S., Gallo A., Sanchez M., DeBrasi D., Gottesman M. E.
RT Reversible inhibition of a thyroid-specific trans-acting factor by Ras
RL Genes Dev. 5:22-28 (1991).
RN [3]; RE0001499.
RX PUBMED: 1922026.
RA Mizuno K., Gonzales F. J., Kimura S.
RT Thyroid-specific enhancer-binding protein (T/EBP): cDNA cloning, functional characterization, and structural identity with thyroid transcription factor TTF-1
RL Mol. Cell. Biol. 11:4927-4993 (1991).
RN [4]; RE0006697.
RX PUBMED: 9226442.
RA Shimamura K., Rubenstein J. L. R.
RT Inductive interactions direct early regionalization of the mouse forebrain
RL Development 124:2709-2718 (1997).
RN [5]; RE0006700.
RX PUBMED: 7774016.
RA Ericson J., Muhr J., Placzek M., Lints T., Jessell T. M., Edlund T.
RT Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube
RL Cell 81:747-756 (1995).
RN [6]; RE0015674.
RX PUBMED: 9533954.
RA Qiu M., Shimamura K., Sussel L., Chen S., Rubenstein J. L.
RT Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development
RL Mech. Dev. 72:77-88 (1998).
RN [7]; RE0022227.
RX PUBMED: 11914369.
RA Weidenfeld J., Shu W., Zhang L., Millar S. E., Morrisey E. E.
RT The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium.
RL J. Biol. Chem. 277:21061-21070 (2002).
RN [8]; RE0025027.
RX PUBMED: 9584181.
RA Sepulveda J. L., Belaguli N., Nigam V., Chen C. Y., Nemer M., Schwartz R. J.
RT GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression.
RL Mol. Cell. Biol. 18:3405-3415 (1998).
XX
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