AC T10232
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ID T10232
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DT 11.02.2007 (created); pra.
DT 31.10.2014 (updated); sup.
CO Copyright (C), QIAGEN.
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FA ipf1
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SY IDX-1; insulin promoter factor 1; IPF-1; ISLET/duodenum homeobox-1; pancreas/duodenum homeobox 1; Pdx1; somatostatin transactivating factor 1; somatostatin transactivating factor-1; STF-1; STF1.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002301 Pdx1.
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CL C0006; homeo.
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SZ 283 AA; 30.8 kDa (cDNA) (calc.), 49 kDa (SDS) [1]
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SQ MNSEEQYYAATQLYKDPCAFQRGPVPEFSANPPACLYMGRQPPPPPPPQFAGSLGTLEQG
SQ SPPDISPYEVPPLADDPAGAHLHHHLPAQLGLAHPPPGPFPNGTETGGLEEPSRVHLPFP
SQ WMKSTKAHAWKSQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELA
SQ VMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTTSGGGGGEEPEQDCAVTSGEELLALPP
SQ PPPPGGAVPSGVPAAAREGRLPSGLSASPQPSSIAPLRPQEPR
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SC translated from EMBL #S67435
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FT 1 79 
transactivation domain [4].
FT 144 204 
PS50071; HOMEOBOX_2.
FT 146 208 
SM00389; HOX_1.
FT 147 203 
PF00046; Homeobox domain.
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CP rec(rat-adenovirus-BHK),rec(rat-adenovirus-alphaTC1),rec(rat-adenovirus-GLUTag),rec(rat-adenovirus-betaTC6) [6].
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IN T01427 p300; human, Homo sapiens.
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MX M01233 V$IPF1_01.
MX M01234 V$IPF1_02.
MX M01235 V$IPF1_03.
MX M01236 V$IPF1_04.
MX M01255 V$IPF1_05.
MX M01438 V$IPF1_06.
MX M00436 V$IPF1_Q4.
MX M01013 V$IPF1_Q4_01.
MX M04614 V$IPF1_Q5_01.
MX M01275 V$IPF1_Q6.
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BS R13054.
BS R15419.
BS R20973.
BS R20974.
BS R29928.
BS R29932.
BS R29933.
BS R21222.
BS R24129.
BS R64620.
BS R64622.
BS R19523.
BS R20620.
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DR TRANSPATH: MO000098805.
DR TRANSCOMPEL: C00455.
DR EMBL: S67435;
DR EMBL: U04833;
DR UniProtKB: P52947;
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RN [1]; RE0005120.
RX PUBMED: 7505393.
RA Leonard J., Peers B., Johnson T., Ferreri K., Lee S., Montminy M. R.
RT Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
RL Mol. Endocrinol. 7:1275-1283 (1993).
RN [2]; RE0008894.
RX PUBMED: 7907546.
RA Miller C. P., McGehee jr R. E., Habener J. F.
RT IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
RL EMBO J. 13:1145-1156 (1994).
RN [3]; RE0015831.
RX PUBMED: 2690822.
RA Boam D. S., Docherty K.
RT A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer
RL Biochem. J. 264:233-239 (1989).
RN [4]; RE0016279.
RX PUBMED: 9199333.
RA Peshavaria M., Henderson E., Sharma A., Wright C. V., Stein R.
RT Functional characterization of the transactivation properties of the PDX-1 homeodomain protein
RL Mol. Cell. Biol. 17:3987-3996 (1997).
RN [5]; RE0048148.
RX PUBMED: 10751390.
RA Schwartz P. T., Perez-Villamil B., Rivera A., Moratalla R., Vallejo M.
RT Pancreatic homeodomain transcription factor IDX1/IPF1 expressed in developing brain regulates somatostatin gene transcription in embryonic neural cells.
RL J. Biol. Chem. 275:19106-19114 (2000).
RN [6]; RE0052754.
RX PUBMED: 15471960.
RA Flock G., Cao X., Drucker D. J.
RT Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells.
RL Endocrinology 146:441-449 (2005).
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