AC T10385
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ID T10385
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DT 12.04.2007 (created); din.
DT 02.04.2008 (updated); dbh.
CO Copyright (C), QIAGEN.
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FA Hey1-isoform1
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SY cardiovascular helix-loop-helix factor 2; CHF2; hairy and enhancer of split related-1; Herp2; hes-related repressor protein 2 herp2; hesr-1; hesr1; hey1; HRT1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004059 HEY1; HGNC: HEY1.
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CL C0010; bHLH.
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SZ 304 AA; 32.6 kDa (calc.).
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SQ MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR
SQ RRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAM
SQ DYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPW
SQ GTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPV
SQ LPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTE
SQ IGAF
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SC translated from EMBL #AJ272214
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FT 2 294 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 50 62 
basic region [1].
FT 50 104 
basic helix-loop-helix domain [1].
FT 50 105 
PS50888; HLH.
FT 52 105 
PF00010; Helix-loop-helix DNA-binding domain.
FT 55 110 
SM00353; finulus.
FT 62 104 
helix-loop-helix motif [1].
FT 120 167 
SM00511; ORANGE.
FT 121 165 
orange domain [1].
FT 121 167 
PF07527; Hairy Orange.
FT 122 158 PS51054; ORANGE.
FT 294 297 YRPW motif [5].
FT 299 304 conserved motif TE(I/V)GAF [1].
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IN T01346 arnt-isoform1; human, Homo sapiens.
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BS R12364.
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DR TRANSPATH: MO000104350.
DR EMBL: AJ272214;
DR UniProtKB: Q9Y5J3;
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RN [1]; RE0017655.
RX PUBMED: 10588864.
RA Nakagawa O., Nakagawa M., Richardson J. A., Olson E. N., Srivastava D.
RT HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.
RL Dev. Biol. 216:72-84 (1999).
RN [2]; RE0017656.
RX PUBMED: 10860664.
RA Steidl C., Leimeister C., Klamt B., Maier M., Nanda I., Dixon M., Clarke R., Schmid M., Gessler M.
RT Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family
RL Genomics 66:195-203 (2000).
RN [3]; RE0017657.
RX PUBMED: 10964718.
RA Maier M. M., Gessler M.
RT Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes
RL Biochem. Biophys. Res. Commun. 275:652-660 (2000).
RN [4]; RE0017667.
RX PUBMED: 11095750.
RA Nakagawa O., McFadden D. G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E. N.
RT Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.
RL Proc. Natl. Acad. Sci. USA 97:13655-13660 (2000).
RN [5]; RE0017201.
RX PUBMED: 10692439.
RA Chin M. T., Maemura K., Fukumoto S., Jain M. K., Layne M. D., Watanabe M., Hsieh C. M., Lee M. E.
RT Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system
RL J. Biol. Chem. 275:6381-6387 (2000).
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