AC T11166
XX
ID T11166
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DT 15.11.2007 (created); ssr.
DT 28.10.2014 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA FKHL5
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SY Freac-1 (Forkhead RElated ACtivator-1); HFH-8; HNF-3/Fkh Homolog 8.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G013777 Foxf1.
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CL C0023; fork head.
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SZ 378 AA; 40.0 kDa (cDNA) (calc.).
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SQ MSAPDKQQPPHGGGTGGGGGAGGQAMDPAAAGPTKAKKTNAGVRRPEKPPYSYIALIVMA
SQ IQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGH
SQ YWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPVYSMVNGLGFNHLPDTYGFQGSGGLSC
SQ APNSLALEGGLGMMNGHLAGNVDGMALPSHSVPHLPSNGGHSYMGGCGGSAAGEYPHHDS
SQ SVPASPLLPAGAGGVMEPHAVYSSSAAAWPPAASAALNSGASYIKQQPLSPCNPAANPLS
SQ GSISTHSLEQPYLHQNSHNGPAELQGIPRYHSQSPSMCDRKEFVFSFNAMASSSMHTTGG
SQ GSYYHQQVTYQDIKPCVM
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SC Swiss-Prot#Q61080
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FT 21 111 
SM00339; forkneu4.
FT 23 117 
PS50039; FORK_HEAD_3.
FT 23 118 
PF00250; Fork head domain.
FT 32 44 
conflict: GPTKAKKTNAGVR -> PHQGQEDQRRRA [2].
FT 48 147 
fork head domain [1].
FT 232 272 
conflict: AGEYPHHDSSVPASPLLPAGAGGVMEPHAVYSSSAAAWPPA -> GRGVPAPRQLGARFTAARPAPAESWSRTPFTPALQQPG [2].
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IN T25961 mkl1-isoform2; mouse, Mus musculus.
IN T05970 myocardin-isoform1; mouse, Mus musculus.
IN T16471 SRF; Mammalia.
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MX M03573 V$FKHL5_Q3.
MX M00809 V$FOX_Q2.
MX M00294 V$HFH8_01.
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BS R05060.
BS R05063.
BS R05061.
BS R05059.
BS R04656.
BS R05064.
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DR TRANSPATH: MO000117656.
DR EMBL: L35949;
DR EMBL: U42556;
DR UniProtKB: Q61080;
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RN [1]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [2]; RE0006874.
RX PUBMED: 7958446.
RA Clevidence D. E., Overdier D. G., Peterson R. S., Porcella A., Ye H., Paulson K. E., Costa R. H.
RT Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter
RL Dev. Biol. 116:195-209 (1994).
RN [3]; RE0006877.
RX PUBMED: 8626802.
RA Hellqvist M., Mahlapuu M., Samuelsson L., Enerbaeck S., Carlsson P.
RT Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2
RL J. Biol. Chem. 271:4482-4490 (1996).
RN [4]; RE0006911.
RX PUBMED: 9486531.
RA Peterson R. S., Linn L., Ye H., Zhou H., Overdier D. G., Costa R. H.
RT The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives
RL Mech. Dev. 69:53-69 (1997).
RN [5]; RE0048271.
RX PUBMED: 16439479.
RA Ormestad M., Astorga J., Landgren H., Wang T., Johansson B. R., Miura N., Carlsson P.
RT Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production.
RL Development 133:833-843 (2006).
RN [6]; RE0048282.
RX PUBMED: 12003781.
RA Kalinichenko V. V., Zhou Y., Shin B., Stolz D. B., Watkins S. C., Whitsett J. A., Costa R. H.
RT Wild-type levels of the mouse Forkhead Box f1 gene are essential for lung repair.
RL Am. J. Physiol. Lung Cell. Mol. Physiol. 282:L1253-65 (2002).
RN [7]; RE0048284.
RX PUBMED: 11124112.
RA Mahlapuu M., Ormestad M., Enerback S., Carlsson P.
RT The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm.
RL Development 128:155-166 (2001).
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