AC T22487
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ID T22487
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DT 02.03.2009 (created); ada.
DT 05.08.2009 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA E2F-8
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SY E2F transcription factor 8; E2F-8; E2F8; FLJ23311; Transcription factor E2F8.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G048816 E2F8; HGNC: E2F8.
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CL C0023; fork head; 3.3.2.1.8.
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FF E2F transcription factors bind the E2F8 promoter and E2F8 is being induced at G1/S transition. [2];
FF Expression of E2F8 inhibits cell proliferation. [2];
FF E2F8 inhibits E2F driven promoters this suggests that E2F8 is a transcriptional repressor. [2];
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IN T06110 E2F-7; human, Homo sapiens.
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DR TRANSPATH: MO000153869.
DR UniProtKB: A0AVK6; F8_HUMAN.
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RN [1]; RE0063166.
RX PUBMED: 18202719.
RA Zalmas L. P., Zhao X., Graham A. L., Fisher R., Reilly C., Coutts A. S., La Thangue N. B.
RT DNA-damage response control of E2F7 and E2F8.
RL EMBO Rep. 9:252-259 (2008).
RN [2]; RE0063187.
RX PUBMED: 16179649.
RA Christensen J., Cloos P., Toftegaard U., Klinkenberg D., Bracken A. P., Trinh E., Heeran M., Di Stefano L., Helin K.
RT Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.
RL Nucleic Acids Res. 33:5458-5470 (2005).
RN [3]; RE0063217.
RX PUBMED: 18194653.
RA Li J., Ran C., Li E., Gordon F., Comstock G., Siddiqui H., Cleghorn W., Chen H. Z., Kornacker K., Liu C. G., Pandit S. K., Khanizadeh M., Weinstein M., Leone G., de Bruin A.
RT Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.
RL Dev. Cell 14:62-75 (2008).
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