AC T25732
XX
ID T25732
XX
DT 23.08.2006 (created); man.
DT 12.07.2013 (updated); ili.
CO Copyright (C), QIAGEN.
XX
FA Notch1-isoform1
XX
SY MOTCH A; MT14; neurogenic locus Notch homolog protein 1; NOTCH 1; Notch1 300kDa protein; Notch1 p300; Notch1 precursor; P300.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G006477 Notch1.
XX
SZ 2531 AA; 270.8 kDa (cDNA) (calc.).
XX
SQ MPRLLTPLLCLTLLPALAARGLRCSQPSGTCLNGGRCEVANGTEACVCSGAFVGQRCQDS
SQ NPCLSTPCKNAGTCHVVDHGGTVDYACSCPLGFSGPLCLTPLDNACLANPCRNGGTCDLL
SQ TLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFESSYICRCPPGFHGPTCRQDVN
SQ ECSQNPGLCRHGGTCHNEIGSYRCACRATHTGPHCELPYVPCSPSPCQNGGTCRPTGDTT
SQ HECACLPGFAGQNCEENVDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQ
SQ LMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFQGATCHDRVASFYCE
SQ CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECALGA
SQ NPCEHAGKCLNTLGSFECQCLQGYTGPRCEIDVNECISNPCQNDATCLDQIGEFQCICMP
SQ GYEGVYCEINTDECASSPCLHNGHCMDKINEFQCQCPKGFNGHLCQYDVDECASTPCKNG
SQ AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCQPGYTGHHC
SQ ETNINECHSQPCRHGGTCQDRDNSYLCLCLKGTTGPNCEINLDDCASNPCDSGTCLDKID
SQ GYECACEPGYTGSMCNVNIDECAGSPCHNGGTCEDGIAGFTCRCPEGYHDPTCLSEVNEC
SQ NSNPCIHGACRDGLNGYKCDCAPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCR
SQ EGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKN
SQ SGVCKESEDYESFSCVCPTGWQGQTCEVDINECVKSPCRHGASCQNTNGSYRCLCQAGYT
SQ GRNCESDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFQGAFCEEDINECASNPCQNGANC
SQ TDCVDSYTCTCPVGFNGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQY
SQ DVNECDSRPCLHGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSAPCKNGGRCWQTNTQ
SQ YHCECRSGWTGVNCDVLSVSCEVAAQKRGIDVTLLCQHGGLCVDEGDKHYCHCQAGYTGS
SQ YCEDEVDECSPNPCQNGATCTDYLGGFSCKCVAGYHGSNCSEEINECLSQPCQNGGTCID
SQ LTNSYKCSCPRGTQGVHCEINVDDCHPPLDPASRSPKCFNNGTCVDQVGGYTCTCPPGFV
SQ GERCEGDVNECLSNPCDPRGTQNCVQRVNDFHCECRAGHTGRRCESVINGCRGKPCKNGG
SQ VCAVASNTARGFICRCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGSFTG
SQ PECQFPASSPCVGSNPCYNQGTCEPTSENPFYRCLCPAKFNGLLCHILDYSFTGGAGRDI
SQ PPPQIEEACELPECQVDAGNKVCNLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYF
SQ SDGHCDSQCNSAGCLFDGFDCQLTEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLD
SQ CAEHVPERLAAGTLVLVVLLPPDQLRNNSFHFLRELSHVLHTNVVFKRDAQGQQMIFPYY
SQ GHEEELRKHPIKRSTVGWATSSLLPGTSGGRQRRELDPMDIRGSIVYLEIDNRQCVQSSS
SQ QCFQSATDVAAFLGALASLGSLNIPYKIEAVKSEPVEPPLPSQLHLMYVAAAAFVLLFFV
SQ GCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNASDGALMDDNQ
SQ NEWGDEDLETKKFRFEEPVVLPDLSDQTDHRQWTQQHLDAADLRMSAMAPTPPQGEVDAD
SQ CMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASLHNQTDRTGET
SQ ALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATDLDA
SQ RMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKN
SQ GANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIV
SQ RLLDEYNLVRSPQLHGTALGGTPTLSPTLCSPNGYLGNLKSATQGKKARKPSTKGLACGS
SQ KEAKDLKARRKKSQDGKGCLLDSSSMLSPVDSLESPHGYLSDVASPPLLPSPFQQSPSMP
SQ LSHLPGMPDTHLGISHLNVAAKPEMAALAGGSRLAFEPPPPRLSHLPVASSASTVLSTNG
SQ TGAMNFTVGAPASLNGQCEWLPRLQNGMVPSQYNPLRPGVTPGTLSTQAAGLQHSMMGPL
SQ HSSLSTNTLSPIIYQGLPNTRLATQPHLVQTQQVQPQNLQLQPQNLQPPSQPHLSVSSAA
SQ NGHLGRSFLSGEPSQADVQPLGPSSLPVHTILPQESQALPTSLPSSMVPPMTTTQFLTPP
SQ SQHSYSSSPVDNTPSHQLQVPEHPFLTPSPESPDQWSSSSPHSNISDWSEGISSPPTTMP
SQ SQITHIPEAFK
XX
SC Swiss-Prot#Q01705-1
XX
FT 20 58 
PS50026; EGF_3.
FT 23 58 
SM00181; EGF.
FT 59 99 
PS50026; EGF_3.
FT 59 99 
SM00179; EGF_CA.
FT 62 99 
SM00181; EGF.
FT 63 98 
PF00008; EGF.
FT 102 139 
PS50026; EGF_3.
FT 105 139 
SM00181; EGF.
FT 106 138 
PF00008; EGF.
FT 106 139 
SM00179; EGF_CA.
FT 140 176 PS50026; EGF_3.
FT 140 176 SM00179; EGF_CA.
FT 143 176 SM00181; EGF.
FT 144 175 PF00008; EGF.
FT 178 215 PF07645; EGF_CA.
FT 178 216 PS50026; EGF_3.
FT 178 216 SM00179; EGF_CA.
FT 181 216 SM00181; EGF.
FT 218 255 PS50026; EGF_3.
FT 221 255 SM00181; EGF.
FT 222 254 PF00008; EGF.
FT 222 255 SM00179; EGF_CA.
FT 257 293 PS50026; EGF_3.
FT 257 293 SM00179; EGF_CA.
FT 260 293 SM00181; EGF.
FT 261 292 PF00008; EGF.
FT 295 332 PF07645; EGF_CA.
FT 295 333 PS50026; EGF_3.
FT 295 333 SM00179; EGF_CA.
FT 298 333 SM00181; EGF.
FT 335 371 PS50026; EGF_3.
FT 335 371 SM00179; EGF_CA.
FT 338 371 SM00181; EGF.
FT 339 370 PF00008; EGF.
FT 372 410 PS50026; EGF_3.
FT 375 410 SM00181; EGF.
FT 376 409 PF00008; EGF.
FT 412 449 PF07645; EGF_CA.
FT 412 450 PS50026; EGF_3.
FT 412 450 SM00179; EGF_CA.
FT 415 450 SM00181; EGF.
FT 452 488 PS50026; EGF_3.
FT 452 488 SM00179; EGF_CA.
FT 455 488 SM00181; EGF.
FT 456 487 PF00008; EGF.
FT 490 526 PS50026; EGF_3.
FT 490 526 SM00179; EGF_CA.
FT 493 526 SM00181; EGF.
FT 494 525 PF00008; EGF.
FT 528 564 PS50026; EGF_3.
FT 528 564 SM00179; EGF_CA.
FT 531 564 SM00181; EGF.
FT 532 563 PF00008; EGF.
FT 566 601 PS50026; EGF_3.
FT 566 601 SM00179; EGF_CA.
FT 569 601 SM00181; EGF.
FT 570 600 PF00008; EGF.
FT 603 639 PS50026; EGF_3.
FT 603 639 SM00179; EGF_CA.
FT 606 639 SM00181; EGF.
FT 607 638 PF00008; EGF.
FT 641 676 PS50026; EGF_3.
FT 641 676 SM00179; EGF_CA.
FT 644 676 SM00181; EGF.
FT 645 675 PF00008; EGF.
FT 678 714 PS50026; EGF_3.
FT 678 714 SM00179; EGF_CA.
FT 681 714 SM00181; EGF.
FT 682 713 PF00008; EGF.
FT 716 751 PS50026; EGF_3.
FT 716 751 SM00179; EGF_CA.
FT 719 751 SM00181; EGF.
FT 720 750 PF00008; EGF.
FT 753 789 PS50026; EGF_3.
FT 753 789 SM00179; EGF_CA.
FT 756 789 SM00181; EGF.
FT 757 788 PF00008; EGF.
FT 791 827 PS50026; EGF_3.
FT 791 827 SM00179; EGF_CA.
FT 794 827 SM00181; EGF.
FT 795 826 PF00008; EGF.
FT 829 867 PS50026; EGF_3.
FT 832 867 SM00181; EGF.
FT 833 866 PF00008; EGF.
FT 833 867 SM00179; EGF_CA.
FT 869 904 PF07645; EGF_CA.
FT 869 905 PS50026; EGF_3.
FT 869 905 SM00179; EGF_CA.
FT 872 905 SM00181; EGF.
FT 907 943 PS50026; EGF_3.
FT 907 943 SM00179; EGF_CA.
FT 910 943 SM00181; EGF.
FT 911 942 PF00008; EGF.
FT 945 981 PS50026; EGF_3.
FT 945 981 SM00179; EGF_CA.
FT 948 981 SM00181; EGF.
FT 949 980 PF00008; EGF.
FT 983 1019 PS50026; EGF_3.
FT 983 1019 SM00179; EGF_CA.
FT 986 1019 SM00181; EGF.
FT 987 1018 PF00008; EGF.
FT 1021 1057 PS50026; EGF_3.
FT 1021 1057 SM00179; EGF_CA.
FT 1024 1057 SM00181; EGF.
FT 1025 1056 PF00008; EGF.
FT 1059 1095 PS50026; EGF_3.
FT 1062 1095 SM00181; EGF.
FT 1063 1094 PF00008; EGF.
FT 1063 1095 SM00179; EGF_CA.
FT 1100 1143 SM00181; EGF.
FT 1101 1143 SM00179; EGF_CA.
FT 1108 1143 PS50026; EGF_3.
FT 1116 1142 PF00008; EGF.
FT 1145 1181 PS50026; EGF_3.
FT 1145 1181 SM00179; EGF_CA.
FT 1148 1181 SM00181; EGF.
FT 1149 1180 PF00008; EGF.
FT 1183 1219 PS50026; EGF_3.
FT 1183 1219 SM00179; EGF_CA.
FT 1186 1219 SM00181; EGF.
FT 1187 1218 PF00008; EGF.
FT 1221 1265 PS50026; EGF_3.
FT 1221 1265 SM00179; EGF_CA.
FT 1224 1265 SM00181; EGF.
FT 1238 1264 PF00008; EGF.
FT 1267 1305 PS50026; EGF_3.
FT 1267 1305 SM00179; EGF_CA.
FT 1270 1305 SM00181; EGF.
FT 1271 1304 PF00008; EGF.
FT 1307 1346 PS50026; EGF_3.
FT 1308 1346 SM00179; EGF_CA.
FT 1310 1346 SM00181; EGF.
FT 1311 1345 PF00008; EGF.
FT 1348 1384 PS50026; EGF_3.
FT 1348 1384 SM00179; EGF_CA.
FT 1351 1384 SM00181; EGF.
FT 1352 1383 PF00008; EGF.
FT 1387 1426 PS50026; EGF_3.
FT 1390 1426 SM00181; EGF.
FT 1391 1425 PF00008; EGF.
FT 1442 1480 PF00066; Notch.
FT 1442 1480 SM00004; NL.
FT 1449 1489 PS50258; LNR.
FT 1483 1522 SM00004; NL.
FT 1485 1522 PF00066; Notch.
FT 1490 1531 PS50258; LNR.
FT 1523 1562 SM00004; NL.
FT 1524 1562 PF00066; Notch.
FT 1532 1571 PS50258; LNR.
FT 1566 1622 PF06816; NOD.
FT 1660 1722 PF07684; NODP.
FT 1863 2102 PS50297; ANK_REP_REGION.
FT 1870 1912 SM00248; ANK.
FT 1870 1915 PF00023; Ank.
FT 1917 1932 PF00023; Ank.
FT 1917 1947 SM00248; ANK.
FT 1937 1948 PF00023; Ank.
FT 1949 1979 SM00248; ANK.
FT 1949 1982 PF00023; Ank.
FT 1983 2012 SM00248; ANK.
FT 1983 2015 PF00023; Ank.
FT 1983 2015 PS50088; ANK_REPEAT.
FT 2016 2045 SM00248; ANK.
FT 2016 2048 PF00023; Ank.
FT 2016 2048 PS50088; ANK_REPEAT.
FT 2049 2078 SM00248; ANK.
FT 2049 2081 PF00023; Ank.
FT 2194 2398 TAD (transactivation domain) [2].
XX
IN T09547 MEF-2C; mouse, Mus musculus.
XX
DR TRANSPATH: MO000085514.
DR EMBL: Z11886;
DR UniProtKB: Q01705-1;
XX
RN [1]; RE0015210.
RX PUBMED: 10082551.
RA Wilson-Rawls J., Molkentin J. D., Black B. L., Olson E. N.
RT Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C
RL Mol. Cell. Biol. 19:2853-2862 (1999).
RN [2]; RE0021256.
RX PUBMED: 9826771.
RA Kurooka H., Kuroda K., Honjo T.
RT Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region
RL Nucleic Acids Res. 26:5448-5455 (1998).
XX
//