AC T00183
XX
ID T00183
XX
DT 26.01.1993 (created); hse.
DT 01.08.2013 (updated); uat.
CO Copyright (C), QIAGEN.
XX
FA DBP
XX
SY DBP.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G009128 Dbp.
XX
HO VBP.
XX
CL C0008; bZIP; 1.1.8.2.1.
XX
SF no heterodimerization with ATF-4 or C/EBPgamma [4];
XX
CP liver-enriched; mRNA: liver, brain, spleen, thymus, lung, kidney, heart, salivary gland; low level: testis.
XX
FF transcriptional activator in hepatic cells [1] [6];
FF member of the C/EBP-family;
FF up to 1000-fold accumulation according to circadian rhythm: barely detectable in the morning, level increases early afternoon, maximum at 8 p.m., sharp decline during the night [5] [8] [2];
FF DBP protein is not yet seen in 1 week old rats, but by 5-25 weeks of age [7];
XX
IN T00183 DBP; rat, Rattus norvegicus.
IN T01071 Hlf; human, Homo sapiens.
IN T01072 TEF; rat, Rattus norvegicus.
XX
MX M00624 V$DBP_Q6.
MX M01872 V$DBP_Q6_01.
MX M07038 V$DBP_Q6_02.
XX
BS R04248.
BS R34687.
BS R00616.
BS R57232.
BS R02987.
BS R25816.
BS R34468.
XX
DR TRANSPATH: MO000024755.
DR UniProtKB: P16443;
XX
RN [1]; RE0000044.
RX PUBMED: 2331750.
RA Mueller C. R., Maire P., Schibler U.
RT DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally
RL Cell 61:279-291 (1990).
RN [2]; RE0000160.
RX PUBMED: 2261643.
RA Wuarin J., Schibler U.
RT Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm
RL Cell 63:1257-1266 (1990).
RN [3]; RE0000774.
RX PUBMED: 1516826.
RA Hunger S. P., Ohyashiki K., Toyama K., Cleary M. L.
RT Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia
RL Genes Dev. 6:1608-1620 (1992).
RN [4]; RE0000787.
RX PUBMED: 8504929.
RA Vinson C. R., Hai T., Boyd S. M.
RT Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design
RL Genes Dev. 7:1047-1058 (1993).
RN [5]; RE0001115.
RX PUBMED: 1297647.
RA Wuarin J., Falvey E., Lavery D., Talbot D., Schmidt E., Ossipow V., Fonjallaz P., Schibler U.
RT The role of the transcriptional activator protein DBP in circadian liver gene expression
RL J. Cell Sci. Suppl. 16:123-127 (1992).
RN [6]; RE0003065.
RA Lavery D. L., Schibler U.
RT DBP and related transcription factors of the PAR family
RL Liver Gene Expression, F. Tronche and M. Yaniv (eds.), R. G. Landes Comp., Austin 1994 0:259-275 (1994).
RN [7]; RE0003092.
RX PUBMED: 1588973.
RA Yano M., Falvey E., Gonzalez F. J.
RT Role of the liver-enriched transcription factor DBP in expression of the cytochrome P450 CYP2C6 gene
RL Mol. Cell. Biol. 12:2847-2854 (1992).
RN [8]; RE0006598.
RX PUBMED: 8617210.
RA Fonjallaz P., Ossipow V., Wanner G., Schibler U.
RT The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue-specific expression, but have different target promoter preferences
RL EMBO J. 15:351-362 (1996).
XX
//