TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01071 XX ID T01071 XX DT 24.02.1994 (created); ewi. DT 09.12.2010 (updated); mka. CO Copyright (C), QIAGEN. XX FA Hlf XX SY hepatic leukemia factor; Hlf. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003946 HLF; HGNC: Hlf. XX HO ces-2 (C. elegans) T03583. XX CL C0008; bZIP; XX SF HLF and E2A-HLF bind to the same consensus sequence, but only HLF interacts with the VBP site of the vitellogenin II gene [2]; XX CP liver (lung, kidney). XX FF fusion to E2A (t(17; FF 19)) leads to expression in lymphoid cells and is found in acute lymphoblastic leukemia; FF E2A-Hlf fusion protein still heterodimerizes with other bZIP/PAR proteins; XX IN T00183 DBP; rat, Rattus norvegicus. IN T04875 DBP; human, Homo sapiens. IN T01071 Hlf; human, Homo sapiens. IN T01072 TEF; rat, Rattus norvegicus. XX MX M00260 V$HLF_01. XX BS R04608. BS R33645. XX DR TRANSPATH: MO000025378. DR UniProtKB: Q16534; XX RN [1]; RE0000774. RX PUBMED: 1516826. RA Hunger S. P., Ohyashiki K., Toyama K., Cleary M. L. RT Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia RL Genes Dev. 6:1608-1620 (1992). RN [2]; RE0005827. RX PUBMED: 8065331. RA Hunger S. P., Brown R., Cleary M. L. RT DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF RL Mol. Cell. Biol. 14:5986-5996 (1994). XX //