AC T01071
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ID T01071
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DT 24.02.1994 (created); ewi.
DT 09.12.2010 (updated); mka.
CO Copyright (C), QIAGEN.
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FA Hlf
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SY hepatic leukemia factor; Hlf.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003946 HLF; HGNC: Hlf.
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HO ces-2 (C. elegans) T03583.
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CL C0008; bZIP; 1.1.8.2.2.
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SF HLF and E2A-HLF bind to the same consensus sequence, but only HLF interacts with the VBP site of the vitellogenin II gene [2];
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CP liver (lung, kidney).
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FF fusion to E2A (t(17;
FF 19)) leads to expression in lymphoid cells and is found in acute lymphoblastic leukemia;
FF E2A-Hlf fusion protein still heterodimerizes with other bZIP/PAR proteins;
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IN T00183 DBP; rat, Rattus norvegicus.
IN T04875 DBP; human, Homo sapiens.
IN T01071 Hlf; human, Homo sapiens.
IN T01072 TEF; rat, Rattus norvegicus.
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MX M00260 V$HLF_01.
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BS R04608.
BS R33645.
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DR TRANSPATH: MO000025378.
DR UniProtKB: Q16534;
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RN [1]; RE0000774.
RX PUBMED: 1516826.
RA Hunger S. P., Ohyashiki K., Toyama K., Cleary M. L.
RT Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia
RL Genes Dev. 6:1608-1620 (1992).
RN [2]; RE0005827.
RX PUBMED: 8065331.
RA Hunger S. P., Brown R., Cleary M. L.
RT DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF
RL Mol. Cell. Biol. 14:5986-5996 (1994).
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