AC T00244
AS T00455, T04214.
XX
ID T00244
XX
DT 15.10.1992 (created); ewi.
DT 04.08.2014 (updated); jtr.
CO Copyright (C), QIAGEN.
XX
FA Egr-1
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SY early growth response protein 1; Early Growth Responsive protein 1; EGR1; Krox-24; NGFI-A; TIS-8; zif268.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G000505 Egr1.
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CL C0001; CH.
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SZ 533 AA; 56.6 kDa (cDNA) (calc.), 54, 84 kDa (SDS)
XX
SQ MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGTPEGSGG
SQ NSSSSTSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTTESFSDIALNNEKAMVETSYPS
SQ QTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPTSSSSAPSPAASSSS
SQ SASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPA
SQ TKGGFQVPMIPDYLFPQQQGDLSLGTPDQKPFQGLENRTQQPSLTPLSTIKAFATQSGSQ
SQ DLKALNTTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIH
SQ TGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQK
SQ DKKADKSVVASPAASSLSSYPSPVATSYPSPATTSFPSPVPTSYSSPGSSTYPSPAHSGF
SQ PSPSVATTFASVPPAFPTQVSSFPSAGVSSSFSTSTGLSDMTATFSPRTIEIC
XX
SC Swiss-Prot#P08046
XX
FT 336 360 
PF00096; zf-C2H2.
FT 336 360 
SM00355; c2h2final6.
FT 336 365 
PS50157; ZINC_FINGER_C2H2_2.
FT 366 388 
PF00096; zf-C2H2.
FT 366 388 
SM00355; c2h2final6.
FT 366 393 
PS50157; ZINC_FINGER_C2H2_2.
FT 394 416 
PF00096; zf-C2H2.
FT 394 416 
SM00355; c2h2final6.
FT 394 421 
PS50157; ZINC_FINGER_C2H2_2.
XX
SF pI = 8.52;
SF 3 zinc finger motifs;
SF phosphorylation, glycosylation;
SF crystal structure (co-crystals with 11-bp DNA);
XX
CP predom. in bone and cartilage (embryogenesis).
XX
FF two subunits, encoded by an immediate-early response gene, involved in signal transduction;
FF early growth response gene;
FF increased by retinoic acid in preosteoblastic cells;
FF for expression in teeth, see [11];
FF enhanced susceptibility to TG-inducible apoptosis through induction of p53 by ectopic Egr-1 [13];
FF alternative translation initiation;
XX
IN T06595 C/EBPbeta-FL; human, Homo sapiens.
IN T02370 Nab1; mouse, Mus musculus.
XX
MX M00243 V$EGR1_01.
MX M02848 V$EGR1_04.
MX M02744 V$EGR1_06.
MX M07354 V$EGR1_Q3.
MX M01873 V$EGR1_Q6.
MX M08878 V$EGR_Q3.
MX M00807 V$EGR_Q6.
MX M00982 V$KROX_Q6.
XX
BS R04818.
BS R04819.
BS R04914.
BS R73972.
BS R02147.
BS R73979.
BS R24693.
BS R24695.
BS R24913.
BS R24915.
BS R04734.
BS R10929.
BS R24952.
BS R24954.
BS R04733.
BS R04878.
BS R04879.
BS R04880.
BS R04881.
BS R04853.
BS R26689.
BS R14632.
BS R24090.
BS R04738.
BS R04739.
BS R03721.
BS R31126.
BS R01614.
BS R01615.
BS R01616.
BS R00721.
BS R29057.
BS R29058.
BS R15104.
BS R04893.
BS R04894.
BS R04913.
BS R14686.
BS R04748.
BS R04749.
BS R09545.
BS R09547.
BS R24218.
BS R29653.
XX
DR TRANSPATH: MO000024798.
DR TRANSCOMPEL: C00213.
DR TRANSCOMPEL: C00214.
DR TRANSCOMPEL: C00216.
DR TRANSCOMPEL: C00223.
DR EMBL: M20157;
DR EMBL: M22326;
DR EMBL: M28844; MMKROX2S1.
DR EMBL: M28845;
DR UniProtKB: P08046;
XX
RN [1]; RE0000235.
RX PUBMED: 3127059.
RA Sukhatme V. P., Cao X., Chang L. C., Tsai-Morris C.-H., Stamenkovich D., Ferreira P. C. P., Cohen D. R., Edwards S. A., Shows T. B., Curran T., Le Beau M. M., Adamson E. D.
RT A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization
RL Cell 53:37-43 (1988).
RN [2]; RE0001008.
RX PUBMED: 2118523.
RA Day M. L., Fahrner T. J., Ayken S., Milbrandt J.
RT The zinc finger protein NGFI-A exists in both nuclear and cytoplasmic forms in nerve growth factor-stimulated PC12 cells
RL J. Biol. Chem. 265:15253-15260 (1990).
RN [3]; RE0001009.
RX PUBMED: 2071571.
RA Gupta M. P., Gupta M., Zak R., Sukhatme V. P.
RT Egr-1, a serum-inducible zinc finger protein, regulates transcription of the rat cardiac alpha-myosin heavy chain gene
RL J. Biol. Chem. 266:12813-12816 (1991).
RN [4]; RE0001470.
RX PUBMED: 1708092.
RA Suva L. J., Ernst M., Rodan G. A.
RT Retinoic acid increases zif268 early gene expression in rat preosteoblastic cells
RL Mol. Cell. Biol. 11:2503-2510 (1991).
RN [5]; RE0002409.
RX PUBMED: 2510170.
RA Christy B., Nathans D.
RT DNA binding site of the growth factor-inducible protein Zif268
RL Proc. Natl. Acad. Sci. USA 86:8737-8741 (1989).
RN [6]; RE0002514.
RX PUBMED: 3133658.
RA Lemaire P., Revelant O., Bravo R., Charnay P.
RT Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells
RL Proc. Natl. Acad. Sci. USA 85:4691-4695 (1988).
RN [7]; RE0002690.
RX PUBMED: 3672127.
RA Milbrandt J.
RT A nerve-growth factor-induced gene encodes a possible transcriptional regulatory factor
RL Science 238:797-799 (1987).
RN [8]; RE0002691.
RX PUBMED: 2028256.
RA Pavletich N. P., Pablo C. O.
RT Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2.1 A
RL Science 252:809-816 (1991).
RN [9]; RE0002755.
RX PUBMED: 2109185.
RA Cao X., Koski R. A., Gashler A., McKiernan M., Morris C. F., Gaffney R., Hay R. V., Sukhatme V. P.
RT Identfication and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals
RL Mol. Cell. Biol. 10:1931-1939 (1990).
RN [10]; RE0002757.
RX PUBMED: 2113174.
RA Lemaire P., Vesque C., Schmitt J., Stunnenberg H., Frank R., Charnay P.
RT The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator
RL Mol. Cell. Biol. 10:3456-3467 (1990).
RN [11]; RE0014809.
RA Pekkanen M., Nieminen P., Sahlberg C., Aberg T., Thesleff I.
RT Gene expression in tooth (WWW database); URL: http://bite-it.helsinki.fi/EGR1.htm
RL Internet : (1996).
RN [12]; RE0016661.
RX PUBMED: 10318795.
RA Dorn C., Ou Q., Svaren J., Crawford P. A., Sadovsky Y.
RT Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1.
RL J. Biol. Chem. 274:13870-13876 (1999).
RN [13]; RE0016822.
RX PUBMED: 9242687.
RA Nair P., Muthukkumar S., Sells S. F., Han S. S., Sukhatme V. P., Rangnekar V. M.
RT Early growth response-1-dependent apoptosis is mediated by p53.
RL J. Biol. Chem. 272:20131-20138 (1997).
RN [14]; RE0030566.
RX PUBMED: 12947119.
RA Zhang F., Lin M., Abidi P., Thiel G., Liu J.
RT Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene.
RL J. Biol. Chem. 278:44246-54 (2003).
XX
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