AC T00267
XX
ID T00267
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DT 15.10.1992 (created); ewi.
DT 27.08.2007 (updated); lyn.
CO Copyright (C), QIAGEN.
XX
FA GATA-1
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SY EF1; EFgammaa; Eryf-1; Eryf1; GF-1; NF-E1; NF-E1a.
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OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
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GE G000060 GATA1.
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CL C0004; CC; 2.2.1.1.1.
XX
SF only zinc finger 2 plus an adjacent basic region is required for DNA-binding [12] [14] [16] [10];
SF DNA binding requires zinc (or other heavy metal ions) [16];
SF zinc finger 1 contributes strongly to the stability of DNA binding at some particular sites R03093, R03213, R00518 [13];
SF 72 kDa: co-purifying minor component with same binding specificity;
SF GATA-1 can interact in vivo with itself and with GATA-2 but not with GATA-5 (in absence of DNA binding activity) [12];
SF late during erythrocyte differentiation mRNA and protein levels of GATA-1 are reduced [17] [18];
XX
CP erythroid cells, megakaryocytes, eosinophils [11] [3].
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FF suppresses myelomonocytic differentiation [11];
FF high levels of GATA-1 in myeloblasts correlate with reprogramming to thromboblast phenotype, intermediate levels with eosinophil phenotype [11];
FF at least in certain transformed cells, it can also induce erythrocyte differentiation [11];
FF ectopic expression can rescue erythroid differentiation of GATA-1 T00305 deficient murine embryonic stem cells [19];
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IN T00267 GATA-1; chick, Gallus gallus.
IN T00307 GATA-2; chick, Gallus gallus.
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MX M00075 V$GATA1_01.
MX M00126 V$GATA1_02.
MX M00127 V$GATA1_03.
MX M00128 V$GATA1_04.
MX M00346 V$GATA1_05.
MX M00347 V$GATA1_06.
MX M02004 V$GATA1_Q6.
MX M00203 V$GATA_C.
MX M00789 V$GATA_Q6.
XX
BS R08219.
BS R08220.
BS R08221.
BS R08222.
BS R08225.
BS R08229.
BS R04798.
BS R04799.
XX
DR TRANSPATH: MO000024816.
DR UniProtKB: P17678;
DR PDB: 1gat.
DR PDB: 1gau.
XX
RN [1]; RE0000167.
RX PUBMED: 2225071.
RA Orkin S. H.
RT Globin gene regulation and switching: Circa 1990
RL Cell 63:665-672 (1990).
RN [2]; RE0000207.
RX PUBMED: 2776214.
RA Evans T., Felsenfeld G.
RT The erythroid-specific transcription factor Eryf1: A new finger protein
RL Cell 58:877-885 (1989).
RN [3]; RE0000674.
RX PUBMED: 2249770.
RA Yamamoto M., Ko L. J., Leonard M. W., Beug H., Orkin S. H., Engel J. D.
RT Activity and tissue-specific expression of the transcription factor NF-E1 multigene family
RL Genes Dev. 4:1650-1662 (1990).
RN [4]; RE0001256.
RX PUBMED: 2761541.
RA Barnhart K. M., Kim C. G., Sheffery M.
RT Purification and characterization of an erythroid cell-specific factor that binds the murine alpha- and beta-globin genes
RL Mol. Cell. Biol. 9:2606-2614 (1989).
RN [5]; RE0001260.
RX PUBMED: 2725505.
RA Knezetic J. A., Felsenfeld G.
RT Identification and Characterization of a Chicken alpha-Globin Enhancer
RL Mol. Cell. Biol. 9:893-901 (1989).
RN [6]; RE0001472.
RX PUBMED: 1990287.
RA Evans T., Felsenfeld G.
RT trans-activation of a globin promoter in nonerythroid cells
RL Mol. Cell. Biol. 11:843-853 (1991).
RN [7]; RE0001979.
RX PUBMED: 2922281.
RA Perkins N. D., Nicolas R. H., Plumb M. A., Goodwin G. H.
RT The purification of an erythroid protein which binds to enhancer and promoter elements of haemoglobin genes
RL Nucleic Acids Res. 17:1299-1314 (1989).
RN [8]; RE0002289.
RX PUBMED: 3413070.
RA Evans T., Reitman M., Felsenfeld G.
RT An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes
RL Proc. Natl. Acad. Sci. USA 85:5976-5980 (1988).
RN [9]; RE0002473.
RX PUBMED: 2014222.
RA Hannon R., Evans T., Felsenfeld G., Gould H.
RT Structure and promoter activity of the gene for the erythroid transcription factor GATA-1
RL Proc. Natl. Acad. Sci. USA 88:3004-3008 (1991).
RN [10]; RE0002989.
RX PUBMED: 1406646.
RA Yang H.-Y., Evans T.
RT Distinct roles for the two cGATA-1 finger domains
RL Mol. Cell. Biol. 12:4562-4570 (1992).
RN [11]; RE0007083.
RX PUBMED: 7758949.
RA Kulessa H., Frampton J., Graf T.
RT GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts
RL Genes Dev. 9:1250-1262 (1995).
RN [12]; RE0010277.
RX PUBMED: 7862128.
RA Yang H.-Y., Evans T.
RT Homotypic interactions of chicken GATA-1 can mediate transcriptional activation
RL Mol. Cell. Biol. 15:1353-1363 (1995).
RN [13]; RE0012279.
RX PUBMED: 8628290.
RA Trainor C. D., Omichinski J. G., Vandergon T. L., Gronenborn A. M., Clore G. M., Felsenfeld G.
RT A palindromic regulatory site within vertebtrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction
RL Mol. Cell. Biol. 16:2238-2247 (1996).
RN [14]; RE0013388.
RX PUBMED: 8332909.
RA Omichinski J. G., Clore G. M., Schaad O., Felsenfeld G., Trainor C., Appella E., Stahl S. J., Gronenborn A. M.
RT NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1.
RL Science 261:438-446 (1993).
RN [15]; RE0013392.
RX PUBMED: 8321208.
RA Ko L. J., Engel J. D.
RT DNA-binding specificities of the GATA transcription factor family.
RL Mol. Cell. Biol. 13:4011-4022 (1993).
RN [16]; RE0013413.
RX PUBMED: 8446581.
RA Omichinski J. G., Trainor C., Evans T., Gronenborn A. M., Clore G. M., Felsenfeld G.
RT A small single-"finger" peptide from the erythroid transcription factor GATA-1 binds specifically to DNA as a zinc or iron complex.
RL Proc. Natl. Acad. Sci. USA 90:1676-1680 (1993).
RN [17]; RE0013440.
RX PUBMED: 8336726.
RA Rousseau S., Asselin M., Renaud J., Ruiz-Carrillo A.
RT Transcription of the histone H5 gene is regulated by three differentiation-specific enhancers.
RL Mol. Cell. Biol. 13:4904-4917 (1993).
RN [18]; RE0013441.
RX PUBMED: 8405392.
RA Sun J.-M., Penner C. G., Davie J. R.
RT Repression of histone H5 gene expression in chicken mature erythrocytes is correlated with reduced DNA-binding activities of transcription factors Sp1 and GATA-1.
RL FEBS Lett. 331:141-144 (1993).
RN [19]; RE0013446.
RX PUBMED: 7823931.
RA Blobel G. A., Simon M. C., Orkin S. H.
RT Rescue of GATA-1-deficient embryonic stem cells by heterologous GATA-binding proteins.
RL Mol. Cell. Biol. 15:626-633 (1995).
XX
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