AC T00630
XX
ID T00630
XX
DT 20.11.1992 (created); ewi.
DT 12.08.2015 (updated); smt.
CO Copyright (C), QIAGEN.
XX
FA POU3F2
XX
SY Brain-2; Brn-2; N-Oct-3.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G009111 POU3F2; HGNC: POU3F2.
XX
CL C0007; POU; 3.1.10.3.2.1.
XX
SZ 443 AA; 46.9 kDa (cDNA) (calc.).
XX
SQ MATAASNHYSLLTSSASIVHAEPPGAMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQ
SQ WITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHG
SQ PGALQQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRTAAAAAHLPPS
SQ MGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPP
SQ PPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYG
SQ NVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTS
SQ IEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLP
SQ GAEDVYGGSRDTPPHHGVQTPVQ
XX
SC Swiss-Prot#P20265-1
XX
FT 1 180 
missing in Oct-5a [3].
FT 1 199 
missing in Oct-5b [3].
FT 262 336 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 262 336 
SM00352; pou.
FT 352 412 
PS50071; HOMEOBOX_2.
FT 352 414 
PS50550; POU_HOMEODOMAIN.
FT 354 416 
SM00389; HOX_1.
FT 355 411 
PF00046; Homeobox domain.
XX
SF Ability of the linker region (336-354) between two POU domain to adopt helical conformation is crucial for homodimerization of this protein on R19764, R19770, and R19771 [5];
SF usage of downstream translation initiation codons gives rise to N-Oct-5a T00632 and -b T00633 [3];
XX
CP nervous system [3]; small cell lung cancer (SCLC) cells [4].
XX
IN T08701 NF-Y; Mammalia.
IN T01427 p300; human, Homo sapiens.
IN T10279 Pax-3; Mammalia.
IN T10436 Sox-10; Mammalia.
IN T08520 TBP-isoform1; human, Homo sapiens.
IN T17428 TFIIB; Mammalia.
XX
MX M00145 V$BRN2_01.
MX M01477 V$OCTAMER_02.
MX M00795 V$OCT_Q6.
MX M00463 V$POU3F2_01.
MX M00464 V$POU3F2_02.
MX M07332 V$POU3F2_Q2.
XX
BS R07241.
BS R07242.
BS R07243.
BS R07244.
BS R07245.
BS R07246.
BS R07247.
BS R07248.
BS R07249.
BS R07250.
BS R07251.
BS R07252.
BS R29772.
BS R04327.
BS R04587.
BS R19771.
BS R19764.
BS R36412.
BS R60725.
BS R19770.
XX
DR TRANSPATH: MO000025068.
DR TRANSCOMPEL: C00498.
DR EMBL: Z11933;
DR UniProtKB: P20265-1;
XX
RN [1]; RE0002117.
RX PUBMED: 2216722.
RA Schreiber E., Harshman K., Kemler I., Malipiero U., Schaffner W., Fontana A.
RT Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins
RL Nucleic Acids Res. 18:5495-5503 (1990).
RN [2]; RE0004221.
RX PUBMED: 2739723.
RA He X., Treacy M. N., Simmons D. M., Ingraham H. A., Swanson L. W., Rosenfeld M. G.
RT Expression of a large family of POU-domain regulatory genes in mammalian brain development
RL Nature 340:35-42 (1989).
RN [3]; RE0004401.
RX PUBMED: 8441633.
RA Schreiber E., Tobler A., Malipiero U., Schaffner W., Fontana A.
RT cDNA cloning of human N-Oct 3, a nervous-system specific POU domain transcripton factor binding to the octamer DNA motif
RL Nucleic Acids Res. 21:253-258 (1993).
RN [4]; RE0004403.
RX PUBMED: 1327524.
RA Schreiber E., Himmelmann A., Malipiero U., Tobler A., Stahel R., Fontana A.
RT Human small cell lung cancer expresses the octamer DNA-binding and nervous system-specific transcription factor N-Oct 3 (Brain-2)
RL Cancer Res. 52:6121-6124 (1992).
RN [5]; RE0048629.
RX PUBMED: 15178247.
RA Blaud M., Vossen C., Joseph G., Alazard R., Erard M., Nieto L.
RT Characteristic patterns of N Oct-3 binding to a set of neuronal promoters.
RL J. Mol. Biol. 339:1049-1058 (2004).
RN [6]; RE0064992.
RX PUBMED: 11029584.
RA Smit D. J., Smith A. G., Parsons P. G., Muscat G. E., Sturm R. A.
RT Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors.
RL Eur. J. Biochem. 267:6413-6422 (2000).
XX
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