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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T00630 XX ID T00630 XX DT 20.11.1992 (created); ewi. DT 12.08.2015 (updated); smt. CO Copyright (C), QIAGEN. XX FA POU3F2 XX SY Brain-2; Brn-2; N-Oct-3. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G009111 POU3F2; HGNC: POU3F2. XX CL C0007; POU; 3.1.10.3.2.1. XX SZ 443 AA; 46.9 kDa (cDNA) (calc.). XX SQ MATAASNHYSLLTSSASIVHAEPPGAMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQ SQ WITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHG SQ PGALQQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRTAAAAAHLPPS SQ MGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPP SQ PPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYG SQ NVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTS SQ IEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLP SQ GAEDVYGGSRDTPPHHGVQTPVQ XX SC Swiss-Prot#P20265-1 XX FT 1 180 missing in Oct-5a [3]. FT 1 199 missing in Oct-5b [3]. FT 262 336 PF00157; Pou domain - N-terminal to homeobox domain. FT 262 336 SM00352; pou. FT 352 412 PS50071; HOMEOBOX_2. FT 352 414 PS50550; POU_HOMEODOMAIN. FT 354 416 SM00389; HOX_1. FT 355 411 PF00046; Homeobox domain. XX SF Ability of the linker region (336-354) between two POU domain to adopt helical conformation is crucial for homodimerization of this protein on R19764, R19770, and R19771 [5]; SF usage of downstream translation initiation codons gives rise to N-Oct-5a T00632 and -b T00633 [3]; XX CP nervous system [3]; small cell lung cancer (SCLC) cells [4]. XX IN T08701 NF-Y; Mammalia. IN T01427 p300; human, Homo sapiens. IN T10279 Pax-3; Mammalia. IN T10436 Sox-10; Mammalia. IN T08520 TBP-isoform1; human, Homo sapiens. IN T17428 TFIIB; Mammalia. XX MX M00145 V$BRN2_01. MX M01477 V$OCTAMER_02. MX M00795 V$OCT_Q6. MX M00463 V$POU3F2_01. MX M00464 V$POU3F2_02. MX M07332 V$POU3F2_Q2. XX BS R07241. BS R07242. BS R07243. BS R07244. BS R07245. BS R07246. BS R07247. BS R07248. BS R07249. BS R07250. BS R07251. BS R07252. BS R29772. BS R04327. BS R04587. BS R19771. BS R19764. BS R36412. BS R60725. BS R19770. XX DR TRANSPATH: MO000025068. DR TRANSCOMPEL: C00498. DR EMBL: Z11933; DR UniProtKB: P20265-1; XX RN [1]; RE0002117. RX PUBMED: 2216722. RA Schreiber E., Harshman K., Kemler I., Malipiero U., Schaffner W., Fontana A. RT Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins RL Nucleic Acids Res. 18:5495-5503 (1990). RN [2]; RE0004221. RX PUBMED: 2739723. RA He X., Treacy M. N., Simmons D. M., Ingraham H. A., Swanson L. W., Rosenfeld M. G. RT Expression of a large family of POU-domain regulatory genes in mammalian brain development RL Nature 340:35-42 (1989). RN [3]; RE0004401. RX PUBMED: 8441633. RA Schreiber E., Tobler A., Malipiero U., Schaffner W., Fontana A. RT cDNA cloning of human N-Oct 3, a nervous-system specific POU domain transcripton factor binding to the octamer DNA motif RL Nucleic Acids Res. 21:253-258 (1993). RN [4]; RE0004403. RX PUBMED: 1327524. RA Schreiber E., Himmelmann A., Malipiero U., Tobler A., Stahel R., Fontana A. RT Human small cell lung cancer expresses the octamer DNA-binding and nervous system-specific transcription factor N-Oct 3 (Brain-2) RL Cancer Res. 52:6121-6124 (1992). RN [5]; RE0048629. RX PUBMED: 15178247. RA Blaud M., Vossen C., Joseph G., Alazard R., Erard M., Nieto L. RT Characteristic patterns of N Oct-3 binding to a set of neuronal promoters. RL J. Mol. Biol. 339:1049-1058 (2004). RN [6]; RE0064992. RX PUBMED: 11029584. RA Smit D. J., Smith A. G., Parsons P. G., Muscat G. E., Sturm R. A. RT Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors. RL Eur. J. Biochem. 267:6413-6422 (2000). XX //