
AC   T00814
XX
ID   T00814
XX
DT   20.10.1992 (created); ewi.
DT   31.03.2009 (updated); ane.
CO   Copyright (C), QIAGEN.
XX
FA   TFEA-xbb1
XX
SY   TFE3-S.
XX
OS   mouse, Mus musculus
OC   eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE   G006798 Tfe3.
XX
CL   C0012; bHLH-ZIP.
XX
SZ   411 AA; 44.1 kDa (calc.).
XX
SQ   TSGTRRREQAAAAPFPSPAPASPAISVIGVSAGGHTLSRPPPAQVPREVLKVQTHLENPT
SQ   RYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPSSAQPLPAPETAHATGPTGSAPNSP
SQ   MALLTIGSSSEKELPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALL
SQ   KERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPEMRWNKGTILKASVDYIRKLQKE
SQ   QQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPNPGLLSLTTSSVSDSLKPE
SQ   QLDIEEEGRPSTTFHVSGGPAQNAPPQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLED
SQ   ILMEEEGMVGGLSGGALSPLRAASDPLLSSVSPAVSNASSRRSSFSIEEES
XX
SC   translated from EMBL #S76673 and edited
XX
FT      182    238   
   PS50888; HLH.
FT      185    238   
   PF00010; Helix-loop-helix DNA-binding domain.
FT      190    243   
   SM00353; finulus.
FT      310    411   
   C-terminal trans-activation domain [3].
XX
FF   trans-dominant negative regulator;
XX
IN   T00814 TFEA-xbb1; mouse, Mus musculus.
IN   T00810 TFEA-xbb2; mouse, Mus musculus.
IN   T00812 tfeb-isoform1; human, Homo sapiens.
XX
MX   M01034 V$EBOX_Q6_01.
MX   M03890 V$TFEA_Q6.
MX   M01029 V$TFE_Q6.
XX
BS   R04253.
BS   R00844.
BS   R00853.
BS   R00240.
BS   R02252.
XX
DR   TRANSPATH: MO000025189.
XX
RN   [1]; RE0002659.
RX   PUBMED: 1840705.
RA   Roman C., Cohn L., Calame K.
RT   A dominant negative form of transcription activator mTFE3 created by differential splicing
RL   Science 254:94-97 (1991).
RN   [2]; RE0003076.
RX   PUBMED: 1732746.
RA   Roman C., Matera A. G., Cooper C., Artandi S., Blain S., Ward D. C., Calame K.
RT   mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization
RL   Mol. Cell. Biol. 12:817-827 (1992).
RN   [3]; RE0006694.
RX   PUBMED: 7479029.
RA   Artandi S. E., Merrell K., Avtiahl N., Wong K.-K., Calame K.
RT   TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription
RL   Nucleic Acids Res. 23:3865-3871 (1995).
XX
//