AC T00810
XX
ID T00810
XX
DT 27.01.1993 (created); hse.
DT 31.03.2009 (updated); ane.
CO Copyright (C), QIAGEN.
XX
FA TFEA-xbb2
XX
SY TFE3.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G006798 Tfe3.
XX
CL C0012; bHLH-ZIP.
XX
SZ 446 AA; 47.9 kDa (cDNA) (calc.).
XX
SQ TSGTRRREQAAAAPFPSPAPASPAISVIGVSAGGHTLSRPPPAQVPREVLKVQTHLENPT
SQ RYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPSSAQPLPAPETAHATGPTGSAPNSP
SQ MALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTAGLQLPSTLPVSGNLLDVYS
SQ SQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIK
SQ ELGTLIPKSNDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRI
SQ QELELQAQIHGLPVPPNPGLLSLTTSSVSDSLKPEQLDIEEEGRPSTTFHVSGGPAQNAP
SQ PQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEGMVGGLSGGALSPLRAASD
SQ PLLSSVSPAVSNASSRRSSFSIEEES
XX
SC translated from EMBL #S76673
XX
FT 7 310 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 121 206 
N-terminal trans-activating region [5].
FT 134 168 
missing in splice variant TFE3-S [2].
FT 217 273 
PS50888; HLH.
FT 220 273 
PF00010; Helix-loop-helix DNA-binding domain.
FT 225 278 
SM00353; finulus.
FT 345 446 
C-terminal trans-activating region [5].
XX
SF the leucine zipper contributes to dimerization specificity [3] [4];
SF tetramers are formed free in solution [4];
SF TFE3 molecules remotely bound to enhancer/promoter elements which may thus interact;
XX
FF TFEA-xbb2 is an approximately 3-fold stronger activator than TFE3-S [2];
FF cooperating with ITF-1, TFE3 can mediate lymphoid-specific activation through combined elements (such as muE5 and muE3 in the IgH enhancer) [1];
XX
IN T02947 E2F-3A; mouse, Mus musculus.
IN T00814 TFEA-xbb1; mouse, Mus musculus.
IN T00810 TFEA-xbb2; mouse, Mus musculus.
IN T00812 tfeb-isoform1; human, Homo sapiens.
XX
MX M01034 V$EBOX_Q6_01.
MX M03890 V$TFEA_Q6.
MX M01029 V$TFE_Q6.
XX
BS R15203.
BS R00853.
BS R15851.
BS R15422.
BS R15425.
BS R15421.
BS R15424.
BS R02252.
XX
DR TRANSPATH: MO000025186.
DR TRANSCOMPEL: C00170.
DR TRANSCOMPEL: C00253.
DR TRANSCOMPEL: C00261.
DR TRANSCOMPEL: C00427.
DR EMBL: S76673;
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RN [1]; RE0000670.
RX PUBMED: 1899229.
RA Ruezinsky D., Beckmann H., Kadesh T.
RT Modulation of the Igh enhancer's cell type through a genetic switch
RL Genes Dev. 5:29-37 (1991).
RN [2]; RE0002659.
RX PUBMED: 1840705.
RA Roman C., Cohn L., Calame K.
RT A dominant negative form of transcription activator mTFE3 created by differential splicing
RL Science 254:94-97 (1991).
RN [3]; RE0003076.
RX PUBMED: 1732746.
RA Roman C., Matera A. G., Cooper C., Artandi S., Blain S., Ward D. C., Calame K.
RT mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization
RL Mol. Cell. Biol. 12:817-827 (1992).
RN [4]; RE0003419.
RX PUBMED: 7969114.
RA Artandi S. E., Cooper C., Shrivastava A., Calame K.
RT The basic helix-loop-helix-zipper domain of TFE3 mediates enhancer-promoter interaction
RL Mol. Cell. Biol. 14:7704-7716 (1994).
RN [5]; RE0006694.
RX PUBMED: 7479029.
RA Artandi S. E., Merrell K., Avtiahl N., Wong K.-K., Calame K.
RT TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription
RL Nucleic Acids Res. 23:3865-3871 (1995).
XX
//