AC T00910
XX
ID T00910
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DT 26.01.1993 (created); ewi.
DT 01.02.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA YB-1
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SY DbpB; YB-1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004962 YBX1; HGNC: YBX1.
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CL C0019; CSD.
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SZ 317 AA; 35.4 kDa (cDNA) (calc.), 52/56 kDa (SDS) [3]
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SQ MSSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIATKVL
SQ GTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGE
SQ EAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEG
SQ QAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRG
SQ YRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDG
SQ KETKAADPPAENSRSRG
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SC Swiss-Prot#P67809
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FT 58 128 
PF00313; 'Cold-shock' DNA-binding domain.
FT 60 128 
SM00357; CSP.
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SF identical to DbpB except Glu-120 (Ala in DbpB) and divergent C-terminal 4 AA [1];
SF two isoforms of 52 and 56 kDa detected in Western blots [3];
SF binds to single-stranded DNA (under multimerization) with 100 times greater affinity than to double-stranded DNA [3] [4];
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FF binds to DNA with intrastrand cross-links between adjacent purines [7];
FF may be a Y-box binding factor [2];
FF activator, synergistic interaction with YB-1 [4];
FF expression is up-regulated by p73alpha T04931 and c-Myc:Max [5];
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IN T00035 AP-2alphaA; human, Homo sapiens.
IN T10782 Smad6; Mammalia.
IN T00910 YB-1; human, Homo sapiens.
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MX M03805 V$YB1_Q3.
MX M03862 V$YB1_Q4.
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BS R21569.
BS R21572.
BS R21575.
BS R21566.
BS R20986.
BS R20989.
BS R08882.
BS R02265.
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DR TRANSPATH: MO000025262.
DR EMBL: J03827;
DR UniProtKB: P67809;
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RN [1]; RE0002105.
RX PUBMED: 1923758.
RA Hasegawa S. L., Doetsch P. W., Hamilton K. K., Martin A. M., Okenquist S. A., Lenz J., Boss J. M.
RT DNA binding properties of YB-1 and dbpA: binding to double-stranded, single-stranded, and abasic site containing DNAs
RL Nucleic Acids Res. 19:4915-4920 (1991).
RN [2]; RE0002419.
RX PUBMED: 3174636.
RA Didier D. K., Schiffenbauer J., Woulfe S. L., Zacheis M., Schwartz B. D.
RT Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box
RL Proc. Natl. Acad. Sci. USA 85:7322-7326 (1988).
RN [3]; RE0014420.
RX PUBMED: 9278454.
RA Mertens P. R., Harendza S., Pollock A. S., Lovett D. H.
RT Glomerular mesangial cell-specific transactivation of matrix metalloproteinase 2 transcription is mediated by YB-1
RL J. Biol. Chem. 272:22905-22912 (1997).
RN [4]; RE0014421.
RX PUBMED: 9830047.
RA Mertens P. R., Alfonso-Jaume M. A., Steinmann K., Lovett D. H.
RT A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription
RL J. Biol. Chem. 273:32957-32965 (1998).
RN [5]; RE0024863.
RX PUBMED: 12080043.
RA Uramoto H., Izumi H., Ise T., Tada M., Uchiumi T., Kuwano M., Yasumoto K., Funa K., Kohno K.
RT p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression.
RL J. Biol. Chem. 277:31694-31702 (2002).
RN [6]; RE0024865.
RX PUBMED: 8657568.
RA Makino Y., Ohga T., Toh S., Koike K., Okumura K., Wada M., Kuwano M., Kohno K.
RT Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter.
RL Nucleic Acids Res. 24:1873-1878 (1996).
RN [7]; RE0048177.
RX PUBMED: 9927044.
RA Ise T., Nagatani G., Imamura T., Kato K., Takano H., Nomoto M., Izumi H., Ohmori H., Okamoto T., Ohga T., Uchiumi T., Kuwano M., Kohno K.
RT Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen.
RL Cancer Res. 59:342-346 (1999).
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