AC T01309
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ID T01309
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DT 22.10.1994 (created); ewi.
DT 02.05.2014 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA CREMtau
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SY CREMtau.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G000532 Crem.
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CL C0008; bZIP.
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SZ 341 AA; 36.6 kDa (cDNA) (calc.).
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SQ MTMETVESQQDRSVTRSVAEHSSAHMQTGQISVPTLAQVSVAGSGTGRGSPAVTLVQLPS
SQ GRTVQVQGVIQTPHPSVIQSPQIQTVQVATIAETDDSADSEVIDSHKRREILSRRPSYRK
SQ ILNELSSDVPGIPKIEEEKSEEEGTPPNIATMAVPTSIYQTSTGQYIAIAQGGTIQISNP
SQ GSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQDEETDLAPSHM
SQ AAATGDMPTYQIRAPTTALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAAKEC
SQ RRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTD
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SC edited Swiss-Prot #P27699
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FT 1 316 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 85 144 
PS50953; KID.
FT 97 137 
PF02173; pKID domain.
FT 152 152 
alternative translation initiation (S-CREM) [4].
FT 281 338 
SM00338; brlzneu.
FT 281 341 
PF00170; bZIP transcription factor.
FT 283 334 
PS50217; BZIP.
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SF encoded by crem exons 1 (B), 2 (C), 3 (E), 4 (F), 5 (G), 6 (X), 7 (H), and the 3'-half of exon 8 (Ib) [12];
SF several splice variants [7];
SF compared to alpha, beta and gamma isoforms, CREMtau contains two additional glutamine-rich regions which exert an activating effect, the second one a stronger than the first one [1] [7];
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CP adult testis; (much weaker:) neuroendocrine tissues [1].
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FF activator [1] [7];
FF required for spermatid differentiation into sperms [8] [10];
FF abrupt switch from repressing CREM isoforms to CREMtau during spermatogenesis [1];
FF alternative initiation usage yields S-CREM;
FF CREMtau is upregulated in CREB -/- mice;
FF mediates PKA-dependent transcriptional stimulation involving Ser-117 [7];
FF Ser-117 is also phosphorylated by p70 S6 kinase [9];
FF along with Ser-117, additional sites are modified by CKI, CKII and other kinases and are thus targeted by several signalling cascades (cAMP, phorbols esters, calcium) [6];
FF these phosphorylations enhance the DNA-binding affinity [6];
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IN T01316 CREMgamma; mouse, Mus musculus.
IN T01309 CREMtau; mouse, Mus musculus.
IN T01319 ICER; rat, Rattus norvegicus.
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MX M00981 V$CREBATF_Q6.
MX M00916 V$CREB_Q2_01.
MX M00801 V$CREB_Q3.
MX M00917 V$CREB_Q4_01.
MX M01820 V$CREM_Q6.
MX M08803 V$CREM_Q6_01.
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BS R61604.
BS R20995.
BS R03925.
BS R03926.
BS R01358.
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DR TRANSPATH: MO000025571.
DR EMBL: M60285;
DR UniProtKB: P27699-1;
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RN [1]; RE0001912.
RX PUBMED: 1370576.
RA Foulkes N. S., Mellstroem B., Benusiglio E., Sassone-Corsi P.
RT Developmental switch of CREM function during spermatogenesis: from antagonist to activator
RL Nature 355:80-84 (1992).
RN [2]; RE0001913.
RX PUBMED: 8102791.
RA Brindle P., Linke S., Montminy M.
RT Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors
RL Nature 364:821-824 (1993).
RN [3]; RE0001915.
RX PUBMED: 8397338.
RA Stehle J. H., Foulkes N. S., Molina C. A., Simonneaux V., Pevet P., Sassone-Corsi P.
RT Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland
RL Nature 365:314-320 (1993).
RN [4]; RE0002559.
RX PUBMED: 1584756.
RA Delmas V., Laoide B. M., Masquilier D., de Groot R. P., Foulkes N. S., Sassone-Corsi P.
RT Alternative usage of initiation codons in mRNA encoding the cAMP-responsive-element modulator generates regulators with opposite functions
RL Proc. Natl. Acad. Sci. USA 89:4226-4230 (1992).
RN [5]; RE0002563.
RX PUBMED: 8202542.
RA Hummler E., Cole T. J., Blendy J. A., Ganss R., Aguzzi A., Schmid W., Beermann F., Schuetz G.
RT Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors
RL Proc. Natl. Acad. Sci. USA 91:5647-5651 (1994).
RN [6]; RE0003156.
RX PUBMED: 8404858.
RA de Groot R.P., den Hertog J., Vandenheede J.R., Goris J., Sassone-Corsi P.
RT Multiple and cooperative phophorylation events regulate the CREM activator function
RL EMBO J. 12:3903-3911 (1993).
RN [7]; RE0003158.
RX PUBMED: 8458330.
RA Laoide B.M., Foulkes N.S., Schlotter F., Sassone-Corsi P.
RT The functional versatility of CREM is determined by its modular structure
RL EMBO J. 12:1179-1191 (1993).
RN [8]; RE0005089.
RX PUBMED: 8538765.
RA Copeland J. W. R., Nasladka A., Dietrich B. H., Krause H. M.
RT Patterning of the Drosophila embryo by a homeodomain-deleted Ftz polypeptide
RL Nature 379:162-165 (1996).
RN [9]; RE0005267.
RX PUBMED: 7923380.
RA de Groot R. P., Ballou L. M., Sassone-Corsi P.
RT Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression
RL Cell 79:81-91 (1994).
RN [10]; RE0005268.
RX PUBMED: 8600390.
RA Nantel F., Monaco L., Foulkes N. S., Masquilier D., LeMeur M., Henriksen K., Dierich A., Parvinen M., Sassone-Corsi P.
RT Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice
RL Nature 380:159-162 (1996).
RN [11]; RE0005269.
RX PUBMED: 7957042.
RA Sassone-Corsi P.
RT Goals for signal transduction pathways: linking up with transcriptional regulation
RL EMBO J. 13:4717-4728 (1994).
RN [12]; RE0000035.
RX PUBMED: 6537904.
RA Parker C. S., Topol J.
RT A Drosophila RNA polymerase II transcription factor contains a promoter-region-specific DNA-binding activity
RL Cell 36:357-369 (1984).
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