AC T01629
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ID T01629
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DT 30.01.1996 (created); ewi.
DT 29.08.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA Atoh2
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SY mammalian atonal homolog 2; MATH-2; NEX-1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006459 Neurod6.
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HO Ato (Drosophila) T01628.
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CL C0010; bHLH; 1.2.3.4.4.
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SF bHLH domain is most closely related to that of MATH-1 (61%) and Ato (53%) [1];
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CP differentiating neurons or glial cells; day 11.5: nervous system including brain vesicles and spinal cord; d13.5: highest in telencephalic wall; d15.5: very low in cerebellum [1]; CNS exclusively [2] [1] [2].
CN heart, kidney, liver, lung, skeletal muscle, small intestine, spleen, stomach [1].
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FF probably involved in neural development in embryos and maintenance of subsets of neural cells in adults [1] [2];
FF after embryonic day 15.5, mRNA is reduced in most organs except cortical plate;
FF persists in cerebrum in neonates and adults [1];
FF subject to positive autoregulation [2];
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IN T00207 E47; human, Homo sapiens.
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DR TRANSPATH: MO000025817.
DR UniProtKB: P48986;
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RN [1]; RE0003638.
RX PUBMED: 7744035.
RA Shimizu C., Akazawa C., Nakanishi S., Kageyama R.
RT MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system
RL Eur. J. Biochem. 229:239-248 (1995).
RN [2]; RE0006807.
RX PUBMED: 7545978.
RA Bartholoma A., Nave K. A.
RT NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons
RL Mech. Dev. 48:217-228 (1994).
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