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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T01629 XX ID T01629 XX DT 30.01.1996 (created); ewi. DT 29.08.2008 (updated); tgo. CO Copyright (C), QIAGEN. XX FA Atoh2 XX SY mammalian atonal homolog 2; MATH-2; NEX-1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G006459 Neurod6. XX HO Ato (Drosophila) T01628. XX CL C0010; bHLH; 1.2.3.4.4. XX SF bHLH domain is most closely related to that of MATH-1 (61%) and Ato (53%) [1]; XX CP differentiating neurons or glial cells; day 11.5: nervous system including brain vesicles and spinal cord; d13.5: highest in telencephalic wall; d15.5: very low in cerebellum [1]; CNS exclusively [2] [1] [2]. CN heart, kidney, liver, lung, skeletal muscle, small intestine, spleen, stomach [1]. XX FF probably involved in neural development in embryos and maintenance of subsets of neural cells in adults [1] [2]; FF after embryonic day 15.5, mRNA is reduced in most organs except cortical plate; FF persists in cerebrum in neonates and adults [1]; FF subject to positive autoregulation [2]; XX IN T00207 E47; human, Homo sapiens. XX DR TRANSPATH: MO000025817. DR UniProtKB: P48986; XX RN [1]; RE0003638. RX PUBMED: 7744035. RA Shimizu C., Akazawa C., Nakanishi S., Kageyama R. RT MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system RL Eur. J. Biochem. 229:239-248 (1995). RN [2]; RE0006807. RX PUBMED: 7545978. RA Bartholoma A., Nave K. A. RT NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons RL Mech. Dev. 48:217-228 (1994). XX //