AC T01634
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ID T01634
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DT 31.01.1996 (created); ewi.
DT 09.07.2015 (updated); sla.
CO Copyright (C), QIAGEN.
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FA NeuroD
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SY beta-cell E-box trans-activator 2; BETA2; NeuroD.
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OS hamster, Cricetulus sp.
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; cricetidae; cricetinae; cricetini
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CL C0010; bHLH; 1.2.3.4.1.
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SF DNA-binding requires heterodimerization with a E47-like molecule [1];
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CP pancreatic alpha and beta cells; islet cell lines, enteroendocrine cell lines, and neurons [2]; pancreatic alpha-cell line (alphaTC), pancreatic B-cell lines [(HIT) hamster;([3TC) mouse; and (RIN) rat] [1].
CN pancreatic ductal cell lines (MDAPanc-3, human; BxPC3, human), pancreatic acinar cell line (AR42J, rat) [1].
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FF activator;
FF acts through the insulin enhancer control element (E-box) [1];
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IN T00204 E12; human, Homo sapiens.
IN T05422 E12; golden (Syrian) hamster, Mesocricetus auratus.
IN T00207 E47; human, Homo sapiens.
IN T05421 E47; golden (Syrian) hamster, Mesocricetus auratus.
IN T01228 Sp1; hamster, Cricetulus sp.
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MX M01287 V$NEUROD_01.
MX M01288 V$NEUROD_02.
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BS R72590.
BS R19184.
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DR TRANSPATH: MO000025821.
DR TRANSCOMPEL: C00278.
DR TRANSCOMPEL: C00516.
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RN [1]; RE0003645.
RX PUBMED: 7774807.
RA Naya F. J., Stellrecht C. M. M., Tsai M.-J.
RT Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor
RL Genes Dev. 9:1009-1019 (1995).
RN [2]; RE0047513.
RX PUBMED: 9108015.
RA Mutoh H., Fung B. P., Naya F. J., Tsai M. J., Nishitani J., Leiter A. B.
RT The basic helix-loop-helix transcription factor BETA2/NeuroD is expressed in mammalian enteroendocrine cells and activates secretin gene expression.
RL Proc. Natl. Acad. Sci. USA 94:3560-3564 (1997).
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