AC T01771
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ID T01771
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DT 18.04.1996 (created); ewi.
DT 23.10.2014 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA MEF-2DAB
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SY MEF-2D; SL-1.
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OS clawed frog, Xenopus laevis
OC eukaryota; animalia; metazoa; chordata; vertebrata; amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae
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CL C0014; MADS.
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SZ 498 AA; 54.1 kDa (cDNA) (calc.).
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SQ MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYAST
SQ DMDKVLLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGDDSIDQSPLMEDKYRKS
SQ SEDLDILFKRYGSAVPAPNFAMPVTVPVTNQNALHFSNPGGSLITQSLMTSSLTDPRLLS
SQ PPQPSLQRNTVSPGLPQRPASAGAMLGGELNNSNGTCPSPVGNGYISARASPGLLPVSNG
SQ NSLGKVIQAKSPPSPNQNSQLGANSRKPDLRVITSQGGKGLMHHLTEEQLEMSVQRLGGV
SQ SQATHSLTTPVVSVATPSLLSHHGLPFSAMSTAYNTDYQLTSADLASLSTFSSPGSLSLG
SQ NVTAWQHQQQQQQQHNQPQQLIPVSLSNLVSSSHLPHTATLTVNTNPINISIKREPASPN
SQ RERSTGTPLSCFSHQSRHEATGRSPVDSLSSNASSFEGNDREDPRGDYTSSLGLLRPSGD
SQ TESESQSVKRMRLDAWVT
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SC conceptually translated from EMBL/GenBank/DDBJ #Z19124
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FT 1 60 
SM00432; MADS.
FT 1 61 
PS50066; MADS_BOX_2.
FT 9 59 
PF00319; SRF-type transcription factor (DNA-binding a.
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CP (embryo:) early tailbud, presumptive heart region [1]; (adult:) high in skeletal muscle, heart, brain, spleen, lower in kidney, liver, stomach, ovary [1] [1].
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FF transcriptional activator, playing a key role in regulation of skeletal and cardiac muscle genes [2];
FF induced by myogenic factors MyoD and Myf-5, no activation of these genes by MEF-2D [2];
FF embryonic stage 8-9, declines during stage 10-11, maximal level by stage 14-15;
FF after stage 18, it decreases again [2];
FF concentrated in posterior somites [2];
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IN T00525 MyoD; human, Homo sapiens.
IN T00526 MyoD; mouse, Mus musculus.
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BS R64471.
BS R64472.
BS R64473.
BS R64474.
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DR TRANSPATH: MO000025912.
DR EMBL: Z19124;
DR UniProtKB: Q03413;
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RN [1]; RE0004083.
RX PUBMED: 1281451.
RA Chambers A. E., Kotecha S., Towers N., Mohun T. J.
RT Muscle-specific expression of SRF-related genes in the early embryo of Xenopus laevis
RL EMBO J. 11:4981-4991 (1992).
RN [2]; RE0004084.
RX PUBMED: 7926733.
RA Chambers A. E., Logan M., Kotecha S., Towers N., Sparrow D., Mohun T. J.
RT The RSRF/MEF2 protein SL1 regulates cardiac muscle-cpecific transcription of a myosin light-chain gene in Xenopus embryos
RL Genes Dev. 8:1324-1334 (1994).
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