AC T01785
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ID T01785
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DT 24.04.1996 (created); ewi.
DT 19.11.2007 (updated); pch.
CO Copyright (C), QIAGEN.
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FA MEF-2B1
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SY MEF-2B; MEF-2B-1; MEF2B; myocyte enhancer factor 2B; RSRFR2; xMEF-2; xMEF2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014309 Mef2b.
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CL C0014; MADS.
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SZ 349 AA; 37.4 kDa (cDNA) (calc.).
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SQ MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCDIALIIFNSAQRLFQYASS
SQ DMDRVLLKYTEYSEPHESRTNADILQTLKRRGVGLDGPELDMEEGPEGPGEKLLRTLGGD
SQ RGSASPRPRIYPVAPAMSVSELSYRVPPATPGCDPGGLGEVPSVHSRPAYFRPPGLGHPI
SQ FSPSHLASKTPPPLYLATDGRRPDLPPGLVGARGGLGTSRSLYSGLQSPGAPGPALGSFA
SQ FLPSGSTDCSPGDAAQGPLQPSPWPPTRDAVDPARPVARSLCKEGPPSRGGSPPTPPVSI
SQ KSERLSPVTGTSGDFPRSFPYPLLLARPLAEPLRPSASLHRLTPDSWPR
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SC translated from EMBL #D50311
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FT 1 60 
SM00432; MADS.
FT 1 61 
PS50066; MADS_BOX_2.
FT 9 59 
PF00319; SRF-type transcription factor (DNA-binding a.
FT 170 349 
trans-activating domain [2].
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SF alternative splice variants are MEF-2B-2 T02501, MEF-2B-3 T02502 and MEF-2B-4 T02503 [3];
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CP (embryo:) precardiac mesoderm (7.5 dpc), cardiac anlage (8 dpc), cardiac muscle (9.5 dpc), skeletal muscle (9.0-16.5 dpc); neurons, neural crest, developing whisker follicles, calcifying cartilage [2].
CN (embryo:) cardiac muscle (after 13.5 dpc); vascular smooth muscle, visceral smooth muscle [2]; (adult:) brain, heart, skeletal muscle [3] [2] [3].
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FF strong activator, synergizing with MyoD/E12 heterodimers [2];
FF exhibits about 34% of human MEF-2A activity [3];
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IN T01012 MEF-2B1; human, Homo sapiens.
IN T01009 RSRFC4; human, Homo sapiens.
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DR TRANSPATH: MO000025922.
DR EMBL: D50311;
DR EMBL: D87831;
DR EMBL: D87833;
DR UniProtKB: O55087-1;
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RN [1]; RE0004145.
RX PUBMED: 7646512.
RA Hidaka K., Morisaki T., Byun S., Hashido K., Toyama K., Mukai T.
RT The MEF2B homologue differentially expressed in mouse embryonal carcinoma cells
RL Biochem. Biophys. Res. Commun. 213:555-560 (1995).
RN [2]; RE0006949.
RX PUBMED: 8668199.
RA Molkentin J. D., Firulli A. B., Black B. L., Martin J. F., Hustad C. M., Copeland N., Jenkins N., Lyons G., Olson E. N.
RT MEF2B is a potent transactivator expressed in early myogenic lineages
RL Mol. Cell. Biol. 16:3814-3824 (1996).
RN [3]; RE0006950.
RX PUBMED: 9443808.
RA Morisaki T., Sermsuvitayawong K., Byun S. H., Matsuda Y., Hidaka K., Morisaki H., Mukai T.
RT Mouse Mef2b gene: unique member of MEF2 gene family
RL J. Biochem. 122:939-946 (1997).
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//