AC T01937
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ID T01937
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DT 05.11.1996 (created); ewi.
DT 07.04.2011 (updated); shs.
CO Copyright (C), QIAGEN.
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FA IkappaB-alpha
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SY Ecl-6/IkappaB-alpha (pig); MAD3 (human); pp40; RL/IF-1 (rat).
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OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
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GE G094252 NFKBIA.
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CL C0020; Rel; 6.1.2.1.1.
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SF at least 4 of the 5 ankyrin repeats have to cooperate with the C-terminal 64 AA for NF-kappaB inhibition [4];
SF physical interaction is required but not sufficient for inhibition [4];
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FF inhibitor of NF-kappaB and c-Rel [2] [3] [4];
FF also associating with v-Rel, but without inhibitory effect on DNA-binding [2] [4];
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IN T01154 c-Rel; chick, Gallus gallus.
IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T).
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DR TRANSPATH: MO000026039.
DR UniProtKB: Q91974;
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RN [1]; RE0000458.
RX PUBMED: 2050119.
RA Urban M. B., Schreck R., Baeuerle P. A.
RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit
RL EMBO J. 10:1817-1825 (1991).
RN [2]; RE0000762.
RX PUBMED: 1907941.
RA Kerr L. D., Inoue J.-I., Davis N., Link E., Baeuerle P. A., Bose jr H. R., Verma I. M.
RT The Rel-associated pp40 protein prevents DNA binding of Rel and NF-kappaB: relationship with IkappaBbeta and regulation by phosphorylation
RL Genes Dev. 5:1464-1476 (1991).
RN [3]; RE0004582.
RX PUBMED: 8441412.
RA Diehl A., McKinsey T. A., Hannink M.
RT Differential pp40IkappaB-beta inhibition of DNA binding by rel proteins
RL Mol. Cell. Biol. 13:1769-1778 (1993).
RN [4]; RE0004603.
RX PUBMED: 1533932.
RA Inoue J., Kerr L. D., Rashid D., Davis N., Bose jr H. R., Verma I. M.
RT Direct association of pp40/IkappaBbeta with rel/NF-kappaB transcription factors: Role of ankyrin repeats in the inhibition of DNA binding activity
RL Proc. Natl. Acad. Sci. USA 89:4333-4337 (1992).
RN [5]; RE0069705.
RX PUBMED: 19917688.
RA Moreno-Garcia M. E., Sommer K., Haftmann C., Sontheimer C., Andrews S. F., Rawlings D. J.
RT Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.
RL J. Immunol. 183:7362-7370 (2009).
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