TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01937 XX ID T01937 XX DT 05.11.1996 (created); ewi. DT 07.04.2011 (updated); shs. CO Copyright (C), QIAGEN. XX FA IkappaB-alpha XX SY Ecl-6/IkappaB-alpha (pig); MAD3 (human); pp40; RL/IF-1 (rat). XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae XX GE G094252 NFKBIA. XX CL C0020; Rel; XX SF at least 4 of the 5 ankyrin repeats have to cooperate with the C-terminal 64 AA for NF-kappaB inhibition [4]; SF physical interaction is required but not sufficient for inhibition [4]; XX FF inhibitor of NF-kappaB and c-Rel [2] [3] [4]; FF also associating with v-Rel, but without inhibitory effect on DNA-binding [2] [4]; XX IN T01154 c-Rel; chick, Gallus gallus. IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T). XX DR TRANSPATH: MO000026039. DR UniProtKB: Q91974; XX RN [1]; RE0000458. RX PUBMED: 2050119. RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). RN [2]; RE0000762. RX PUBMED: 1907941. RA Kerr L. D., Inoue J.-I., Davis N., Link E., Baeuerle P. A., Bose jr H. R., Verma I. M. RT The Rel-associated pp40 protein prevents DNA binding of Rel and NF-kappaB: relationship with IkappaBbeta and regulation by phosphorylation RL Genes Dev. 5:1464-1476 (1991). RN [3]; RE0004582. RX PUBMED: 8441412. RA Diehl A., McKinsey T. A., Hannink M. RT Differential pp40IkappaB-beta inhibition of DNA binding by rel proteins RL Mol. Cell. Biol. 13:1769-1778 (1993). RN [4]; RE0004603. RX PUBMED: 1533932. RA Inoue J., Kerr L. D., Rashid D., Davis N., Bose jr H. R., Verma I. M. RT Direct association of pp40/IkappaBbeta with rel/NF-kappaB transcription factors: Role of ankyrin repeats in the inhibition of DNA binding activity RL Proc. Natl. Acad. Sci. USA 89:4333-4337 (1992). RN [5]; RE0069705. RX PUBMED: 19917688. RA Moreno-Garcia M. E., Sommer K., Haftmann C., Sontheimer C., Andrews S. F., Rawlings D. J. RT Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes. RL J. Immunol. 183:7362-7370 (2009). XX //