AC T01961
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ID T01961
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DT 21.11.1996 (created); ewi.
DT 26.01.2011 (updated); sla.
CO Copyright (C), QIAGEN.
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FA Lim-1
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SY Lhx-1; LIM homeobox protein 1; Lim-1; Xlim-1 (Xenopus).
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002214 Lhx1.
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CL C0025; LIM-homeo; 3.1.5.2.1.
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SF highest expression level is seen at embryonic stage 13.5 [2];
SF Lim-1 -/- mutants lack anterior head structures, some develop a partial second body axis [1];
SF expression in the CNS is seen in the telencephalon and the spinal cord, in the excretory system in the pronephric region, the mesonephros, nephric duct, and metanephros (renal vesicles, S-shaped bodies, ureteric branches) [2];
SF Lim-1 and Lhx2 T01969 exhibit complementary expression domains in the embryonic brain [4];
SF 97% amino acid identity to human LHX1 T01960 [5];
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CP embryo stage 10.5 (very weak), stage 11.5-14.5 (high level) in the central nervous system and excretory system; adult: brain [2]; (embryo 12 days:) ventral thalamus, ventromedial mesencephalon [4] [4] [2].
CN adult: liver, ovary, uterus [2].
EX Hypothalamus primordium,,,Theiler Stage 21; low; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX central nervous system,,,Theiler Stage 15; none; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX diencephalon,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX lateral motor column of spinal cord,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX medial ventricular eminence of diencephalon,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX mesencephalon,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX mesencephalon,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX mesonephros,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX rhombencephalon,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX rhombencephalon,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX spinal cord,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
EX thalamus,,,Theiler Stage 21; low; RNA-in situ hybridization (not further specified); RNA (undefined); [6].
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FF as an essential regulator of the head organizer, it is required for normal development of head structures [1];
FF important role in neural development and region-specific differentiation in the developing brain [4];
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IN T02252 CLIM2; mouse, Mus musculus.
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MX M01418 V$LIM1_01.
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DR TRANSPATH: MO000026055.
DR UniProtKB: P63006;
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RN [1]; RE0004766.
RX PUBMED: 7700351.
RA Shawlot W., Behringer R. R.
RT Requirement for Lim1 in head-organizer function
RL Nature 374:425-430 (1995).
RN [2]; RE0004769.
RX PUBMED: 7909459.
RA Fujii T., Pichel J. G., Taira M., Toyama R., Dawid I. B., Westphal H.
RT Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system
RL Dev. Dyn. 199:73-83 (1994).
RN [3]; RE0004770.
RX PUBMED: 7904966.
RA Barnes J. D., Crosby J. L., Jones C. M., Wright C. V., Hogan B. L. H.
RT Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis
RL Dev. Biol. 161:168-178 (1994).
RN [4]; RE0015588.
RX PUBMED: 8817562.
RA Matsumoto K., Tanaka T., Furuyama T., Kashihara Y., Ishii N., Tohyama M., Kitanaka J., Takemura M., Mori T., Wanaka A.
RT Differential expression of LIM-homeodomain genes in the embryonic murine brain
RL Neurosci. Lett. 211:147-150 (1996).
RN [5]; RE0015711.
RX PUBMED: 9212161.
RA Dong W. F., Heng H. H., Lowsky R., Xu Y., DeCoteau J. F., Shi X. M., Tsui L. C., Minden M. D.
RT Cloning, expression, and chromosomal localization to 11p12-13 of a human LIM/HOMEOBOX gene, hLim-1
RL DNA Cell Biol. 16:671-678 (1997).
RN [6]; RE0015599.
RX PUBMED: 9022063.
RA Sheng H. Z., Bertuzzi S., Chiang C., Shawlot W., Taira M., Dawid I., Westphal H.
RT Expression of murine Lhx5 suggests a role in specifying the forebrain
RL Dev. Dyn. 208:266-277 (1997).
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