AC T01969
XX
ID T01969
XX
DT 21.11.1996 (created); ewi.
DT 04.03.2015 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA Lhx2
XX
SY ap; Apterous; LH-2; LH2A; LHX2; LIM homeobox protein 2; Lim2.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G004532 Lhx2.
XX
HO Ap (Drosophila) T01074.
XX
CL C0025; LIM-homeo; 3.1.5.3.1.
XX
SF Lhx2 and Lhx1 T01961 exhibit complementary expression domains in the embryonic brain [2];
XX
CP brain, pre-B cell lines, T cell lines, lower levels in spinal cord (embryonic day 13.5 only), very low in fetal liver; adult brain: cortex, midbrain, olfactory bulb, striatum, thalamus/hippocampus, very low in hindbrain, cerebellum [1]; More abundant in alphaT3-1, alpha TSH, less abundant in AtT20, whole rat pituitary cells, GH3 cells [4].
CN heart, intestine, kidney, lung, spleen, thymus [1]; JEG3, mouse liver [4].
EX cerebral cortex,,,Theiler Stage 21; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX cerebral cortex,,,Theiler Stage 28; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX cerebral cortex,,,Theiler Stage 28; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX external granular layer of cerebellar cortex,,,Theiler Stage 28; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX eye and related structures (right and left),,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX forelimb bud,,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX hindlimb bud,,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX hippocampus,,,Theiler Stage 28; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX hypothalamus,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX lateral ganglionic eminence (LGE),,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX medial ganglionic eminence (MGE),,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX olfactory epithelium,,,Theiler Stage 21; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX optic stalk,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX preoptic area,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX preplate of cerebral cortex,superficial cell,,Theiler Stage 21; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX retina,,,Theiler Stage 21; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX subthalamus,,,Theiler Stage 23; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX telencephalic vesicle,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX thalamus,,,Theiler Stage 21; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX thalamus,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX ventricular layer of the cerebral cortex,,,Theiler Stage 21; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
XX
FF important role in neural development and region-specific differentiation in the developing brain [2];
FF similar expression pattern to Drosophila homolog T01074 (also expressed in nerve cords, eyes, olfactory organs, brain, and limbs) [3];
XX
MX M01325 V$LHX2_01.
MX M07047 V$LHX2_Q4.
MX M07385 V$LHX2_Q6.
XX
BS R09043.
BS R70002.
BS R66390.
BS R66392.
BS R66393.
BS R66397.
BS R66565.
BS R66567.
BS R66570.
BS R70001.
BS R16187.
XX
DR TRANSPATH: MO000026061.
DR TRANSCOMPEL: C00453.
DR UniProtKB: Q9Z0S2;
XX
RN [1]; RE0004773.
RX PUBMED: 7678338.
RA Xu Y., Baldassare M., Fisher P., Rathbun G., Oltz E. M., Yancopoulos G. D., Jessell T. M., Alt F. W.
RT LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells
RL Proc. Natl. Acad. Sci. USA 90:227-231 (1993).
RN [2]; RE0015588.
RX PUBMED: 8817562.
RA Matsumoto K., Tanaka T., Furuyama T., Kashihara Y., Ishii N., Tohyama M., Kitanaka J., Takemura M., Mori T., Wanaka A.
RT Differential expression of LIM-homeodomain genes in the embryonic murine brain
RL Neurosci. Lett. 211:147-150 (1996).
RN [3]; RE0017735.
RX PUBMED: 10051612.
RA Rincon-Limas D. E., Lu C. H., Canal I., Calleja M., Rodriguez-Esteban C., Izpisua-Belmonte J. C., Botas J.
RT Conservation of the expression and function of apterous orthologs in Drosophila and mammals.
RL Proc. Natl. Acad. Sci. USA 96:2165-2170 (1999).
RN [4]; RE0028382.
RX PUBMED: 7513049.
RA Roberson M. S., Schoderbek W. E., Tremml G., Maurer R. A.
RT Activation of the glycoprotein hormone alpha-subunit promoter by a LIM-homeodomain transcription factor.
RL Mol. Cell. Biol. 14:2985-93 (1994).
RN [5]; RE0015590.
RX PUBMED: 9880598.
RA Retaux S., Rogard M., Bach I., Failli V., Besson M. J.
RT Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain
RL J. Neurosci. 19:783-793 (1999).
RN [6]; RE0015591.
RX PUBMED: 10330499.
RA Bertuzzi S., Porter F. D., Pitts A., Kumar M., Agulnick A., Wassif C., Westphal H.
RT Characterization of Lhx9, a novel LIM/homeobox gene expressed by the pioneer neurons in the mouse cerebral cortex
RL Mech. Dev. 81:193-198 (1999).
XX
//