AC T02057
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ID T02057
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DT 28.01.1997 (created); ewi.
DT 19.02.2015 (updated); ros.
CO Copyright (C), QIAGEN.
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FA ipf1
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SY IDX-1; insulin promoter factor 1; IPF-1; ISLET/duodenum homeobox-1; pancreas/duodenum homeobox 1; pancreas/duodenum homeobox-1; Pdx1; somatostatin transactivating factor 1; somatostatin transactivating factor-1; STF-1; STF1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002300 Pdx1.
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HO XlHBox (Xenopus) T04541, Htr-A2 (leech).
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CL C0006; homeo; 3.1.1.15.1.
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SF may constitute an own homeo domain protein family (SHX family) together with XlHBox 8 (X. laevis) T04541 and Htr-A2 (Helobdella triseralis) [2];
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CP pancreas beta-cells [1]; expressed in the pancreatic beta-cells [11]; expression in pancreatic ductal cells, beta TC3 cells, and mouse islets [12]; PDX1 is expressed at low level in the pancreatic ductal cells, and at high level in Min6 [13]; expression in pancreatic ductal cells, beta TC3 cells, and mouse islets [12]; AlphaTC1,GLUTag,betaTC6 [14].
CN pancreas alpha-cells [1]; PDX1 is not expressed in PANC-1 and HeLa cells [13].
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FF activator [1];
FF necessary, though not sufficient for insulin gene activation [3];
FF absolutely required for pancreas development in being involved in the regionalization of the primitive gut endoderm and in maturation of pancreas-beta cells [1] [4];
FF expressed very early in pancreas progenitor cells of the primitive foregut [1];
FF may have an important role in beta-cell maturation [5];
FF activator of islet beta- and delta-cell-specific expression of the islet amyloid polypeptide gene (IAPP) gene [5] [6];
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IN T23418 HDAC1; mouse, Mus musculus.
IN T04140 hdac2; mouse, Mus musculus.
IN T33293 Ku80; mouse, Mus musculus.
IN T08226 MafA; mouse, Mus musculus.
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MX M01233 V$IPF1_01.
MX M01234 V$IPF1_02.
MX M01235 V$IPF1_03.
MX M01236 V$IPF1_04.
MX M01255 V$IPF1_05.
MX M01438 V$IPF1_06.
MX M00436 V$IPF1_Q4.
MX M01013 V$IPF1_Q4_01.
MX M02096 V$IPF1_Q5.
MX M04614 V$IPF1_Q5_01.
MX M01275 V$IPF1_Q6.
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BS R30055.
BS R19481.
BS R19482.
BS R10024.
BS R10025.
BS R02709.
BS R02712.
BS R20722.
BS R20723.
BS R20727.
BS R36167.
BS R29135.
BS R29138.
BS R29139.
BS R14650.
BS R14651.
BS R25191.
BS R25192.
BS R25193.
BS R25222.
BS R30214.
BS R19216.
BS R21510.
BS R32699.
BS R20795.
BS R42251.
BS R18137.
BS R19509.
BS R32379.
BS R15491.
BS R21222.
BS R24129.
BS R18132.
BS R37296.
BS R40058.
BS R64622.
BS R19519.
BS R20620.
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DR TRANSPATH: MO000007666.
DR TRANSCOMPEL: C00455.
DR UniProtKB: P52946;
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RN [1]; RE0005119.
RX PUBMED: 7901001.
RA Ohlsson H., Karlsson K., Edlund T.
RT IPF1, a homeodamain-containing transactivator of the insulin gene
RL EMBO J. 12:4251-4259 (1993).
RN [2]; RE0005120.
RX PUBMED: 7505393.
RA Leonard J., Peers B., Johnson T., Ferreri K., Lee S., Montminy M. R.
RT Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
RL Mol. Endocrinol. 7:1275-1283 (1993).
RN [3]; RE0005121.
RX PUBMED: 7937976.
RA Petersen H. V., Serup P., Leonhard J., Michelsen B. K., Madsen O. D.
RT Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes
RL Proc. Natl. Acad. Sci. USA 91:10465-10469 (1994).
RN [4]; RE0005122.
RX PUBMED: 7935793.
RA Jonsson J., Carlsson L., Edlund T., Edlund H.
RT Insulin-promoter-factor 1 is required for pancreas development in mice
RL Nature 371:606-609 (1994).
RN [5]; RE0013232.
RX PUBMED: 8799146.
RA Serup P., Jensen J., Andersen F. G., Jorgensen M. C., Blume N., Holst J. J., Madsen O. D.
RT Induction of insulin and islet amyloid polypeptide productions in pancreatic islet glucagonoma cells by insulin promoter factor 1
RL Proc. Natl. Acad. Sci. USA 93:9015-9020 (1996).
RN [6]; RE0016268.
RX PUBMED: 9115263.
RA Carty M. D., Lillquist J. S., Peshavaria M., Stein R., Soeller W. C.
RT Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells
RL J. Biol. Chem. 272:11986-11993 (1997).
RN [7]; RE0047888.
RX PUBMED: 15496408.
RA Mosley A. L., Ozcan S.
RT The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose.
RL J. Biol. Chem. 279:54241-54247 (2004).
RN [8]; RE0055186.
RX PUBMED: 10426567.
RA Furukawa N., Shirotani T., Araki E., Kaneko K., Todaka M., Matsumoto K., Tsuruzoe K., Motoshima H., Yoshizato K., Kishikawa H., Shichiri M.
RT Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway.
RL Endocr. J. 46:43-58 (1999).
RN [9]; RE0055193.
RX PUBMED: 16166097.
RA Lebrun P., Montminy M. R., Van Obberghen E.
RT Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase.
RL J. Biol. Chem. 280:38203-38210 (2005).
RN [10]; RE0055527.
RX PUBMED: 18772243.
RA Boucher M. J., Simoneau M., Edlund H.
RT The homeodomain-interacting protein kinase 2 regulates insulin promoter factor-1/pancreatic duodenal homeobox-1 transcriptional activity.
RL Endocrinology 150:87-97 (2009).
RN [11]; RE0025709.
RX PUBMED: 11825903.
RA Chakrabarti S. K., James J. C., Mirmira R. G.
RT Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding.
RL J. Biol. Chem. 277:13286-93 (2002).
RN [12]; RE0050301.
RX PUBMED: 16901969.
RA Francis J., Babu D. A., Deering T. G., Chakrabarti S. K., Garmey J. C., Evans-Molina C., Taylor D. G., Mirmira R. G.
RT Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.
RL Mol. Endocrinol. 20:3133-3145 (2006).
RN [13]; RE0049916.
RX PUBMED: 17056599.
RA Deramaudt T. B., Sachdeva M. M., Wescott M. P., Chen Y., Stoffers D. A., Rustgi A. K.
RT The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter.
RL J. Biol. Chem. 281:38385-38395 (2006).
RN [14]; RE0052754.
RX PUBMED: 15471960.
RA Flock G., Cao X., Drucker D. J.
RT Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells.
RL Endocrinology 146:441-449 (2005).
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